Heterocyclic Building Blocks-Tetrahydroisoquinoline

Sokolenko, V. A.; Bondarenko, V. S.; Korniets, E. D.; Kovtonyuk, N. P.; Kovrova, N. B. published the article 《Solid-phase condensation of coordinated pyridine and γ-picoline in platinum(II) complexes》. Keywords: thermolysis platinum picoline pyridine complex; condensation picoline pyridine coordinated platinum.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Electric Literature of C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The thermolysis of cis- and trans-[PtL2Cl2] (L = py, γ-picoline (pic)) was studied by IR and 1H NMR spectroscopy. cis-[PtL2Cl2] underwent cis-trans isomerization in the solid state at 200-220°. Thermolysis of trans-[PtL2Cl2] at 240-300° led to condensation of coordinated L to give PtL1Cl2 (L1 = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine). Thermolysis of [Pt(pic)4]Cl2 gave trans-Pt(pic)2Cl2 at 160°.

Here is just a brief introduction to this compound(15227-42-6)Electric Literature of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called CO2 Hydrogenation and Formic Acid Dehydrogenation Using Ir Catalysts with Amide-Based Ligands, published in 2020-05-11, which mentions a compound: 1452-77-3, Name is Picolinamide, Molecular C6H6N2O, Computed Properties of C6H6N2O.

A series of Ir catalysts [Cp*Ir(H2O)(QCXNHR)][SO4] (1-16; Q = 2-pyridyl, 4-hydroxy-2-pyridyl, 6-hydroxy-2-pyridyl, 2-imidazolyl, 1-pyrazolyl; X = O, S, NH; R = H, Me, Ph, 4-hydroxyphenyl) bearing amide-based ligands were isolated or generated in situ by a deprotonated amide moiety with the hypotheses that strong electron-donating ability of the coordinated anionic nitrogen atom and the proton-responsive OH group near the metal center will improve the catalytic activity for CO2 hydrogenation and formic acid (FA) dehydrogenation. The effects of the modifications of the ligand architecture on the catalytic activity were investigated for CO2 hydrogenation at ambient conditions (25° with 0.1 MPa H2/CO2 (volume/volume = 1/1)) and under slightly harsher conditions (50° with 1.0 MPa H2/CO2) in basic aqueous solutions together with deuterium kinetic isotope effects (KIEs) with selected catalysts. Complex [Cp*Ir(L12)(H2O)][HSO4] (12, L12 = 6-hydroxy-N-phenylpicolinamidate) that has an anionic coordinating N atom and an OH group in the second coordination sphere, exhibits a TOF of 198 h-1 based on the initial 1 h of reaction. This TOF which, to the best of our knowledge, is the highest value ever reported under ambient conditions in basic aqueous solutions However, complex [Cp*Ir(L10)(H2O)][HSO4] (L10 = 4-hydroxy-N-methylpicolinamidate) performs better in long-term CO2 hydrogenation (up to a TON of 14700 with [Ir] = 10μM after 348 h and the final formate concentration of 0.643 M with [Ir] = 250μM.) at ambient conditions. Further, the catalytic activity for FA dehydrogenation was examined under three different conditions (pH 1.6, 2.3 and 3.5). The complex 12 in any of these conditions is less active compared to the picolinamidate catalysts without ortho-OH, owing to its instability. Theor. calculations were performed to examine the catalytic mechanism, and a step-by-step mechanism has been proposed for both CO2 hydrogenation and FA dehydrogenation reactions. D. functional theory calculations of [Cp*Ir(L3)(H2O)][HSO4] (L3 = picolinamidate) and the X-ray structure of the [Cp*Ir(L7)(H)]•H2O (L7 = N-methylpicolinamidate) complex imply a pH-dependent conformational change from N,N coordination to N,O coordination upon lowering the pH of the aqueous solution

Here is just a brief introduction to this compound(1452-77-3)Computed Properties of C6H6N2O, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Thirukovela, Narasimha Swamy; Balaboina, Ramesh; Kankala, Shravankumar; Vadde, Ravindhar; Vasam, Chandra Sekhar researched the compound: Picolinamide( cas:1452-77-3 ).Synthetic Route of C6H6N2O.They published the article 《Activation of nitriles by silver(I) N-heterocyclic carbenes: An efficient on-water synthesis of primary amides》 about this compound( cas:1452-77-3 ) in Tetrahedron. Keywords: silver NHC catalyst preparation; nitrile silver NHC catalyst hydration; primary amide preparation. We’ll tell you more about this compound (cas:1452-77-3).

A first example of silver(I) N-heterocyclic carbene (Ag(I)-NHC) catalyzed on-water synthesis of primary amides by hydration of nitriles under mild reaction conditions was described. This organometallic catalytic system has excellent tolerance for various homo-aromatic, hetero-aromatic and aliphatic nitriles to afford primary amides in good yields in neat water.

Here is just a brief introduction to this compound(1452-77-3)Synthetic Route of C6H6N2O, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Microcalorimetric studies of the thermal decomposition of ammonia-halide and amine-halide complexes of platinum(II), [Pt(NH2R)2X2]. Author is Al Takhin, Ghassan; Skinner, Henry A.; Zaki, Ahmed A..

The standard heats of formation of the crystalline compounds [PtL2X2] [L = NH2R (R = H, Me, CHMe2, Bu, Et, Pr, CH2CHMe2), en, pyridine; X = Cl, Br, I] were derived from the enthalpies of thermal decomposition of their cis isomers at elevated temperatures The enthalpy of sublimation (ΔHsub) of [PtL2Cl2] (L = pyridine) is estimated as 170 kJ/mol, which gives an average pyridine-Pt bond-dissociation enthalpy of 122 kJ/mol in the gas phase. For other amine ligands, the bond-dissociation enthalpy is less than for the pyridine complex, falling to a min. of 97 kJ/mol for NH3. These imply sublimation heats of 270-300 kJ/mol in the Cl complexes.

Here is just a brief introduction to this compound(15227-42-6)Category: tetrahydroisoquinoline, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

COA of Formula: C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Hydroxy complexes of platinum(II) and palladium(II). Author is Bushnell, Gordon William; Dixon, Keith Roger; Hunter, Robert George; McFarland, John James.

The preparation of hydroxy bridged complexes, [M2(OH)2-L4][BF4]2, where M = Pt and L = Et3P, Ph3P or py, or where M = Pd and L = Ph3P, is described. The structures are unambiguously established by ir, NMR, and x-ray crystallog. studies. The complexes are stable and resist bridge cleavage by tertiary phosphines under conditions which easily cleave analogous chloro bridged complexes.

Here is just a brief introduction to this compound(15227-42-6)COA of Formula: C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

HPLC of Formula: 693-67-4. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Direct Trifluoromethoxylation without OCF3-Carrier through In Situ Generation of Fluorophosgene. Author is Saiter, Jeremy; Guerin, Thomas; Donnard, Morgan; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R..

The method represented the preparation of a range of trifluoromethoxylated structures R-OCF3 [R = undecanyl, (CH2)2Ph, 4-BrC6H4CH2, etc.] with no use of an intermediate trifluoromethoxylating reagent, but in situ construction and use of the F3CO anion as a salt, avoiding the presence of a useless side-product resulting from activation of an OCF3 carrier.

Here is just a brief introduction to this compound(693-67-4)HPLC of Formula: 693-67-4, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain.Formula: C6H6N2O.

Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate transmission in the human forebrain. However, no reliable positron emission tomog. (PET) radiotracer allowing for in vivo visualization of mGluR2 in the human brain is currently available. In this study, we synthesized 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide ([11C]1) and evaluated its potential as a PET tracer for imaging mGluR2 in the rodent brain. Compound 1, a neg. allosteric modulator (NAM) of mGluR2, showed high in vitro binding affinity (IC50: 26 nM) for mGluR2 overexpressed in human cells. [11C]1 was synthesized by O-[11C]methylation of the phenol precursor 2 with [11C]methyl iodide. After the reaction, HPLC purification and formulation, [11C]1 of 7.4 ± 2.8 GBq (n = 8) was obtained from [11C]carbon dioxide of 22.5 ± 4.8 GBq (n = 8) with >99% radiochem. purity and 70 ± 32 GBq/μmol (n = 8) molar activity at the end of synthesis. In vitro autoradiog. for rat brains showed that [11C]1 binding was heterogeneously distributed in the cerebral cortex, striatum, hippocampus, and cerebellum. This pattern is consistent with the regional distribution pattern of mGluR2 in the rodent brain. The radioactivity was significantly reduced by self- or MNI-137 (a mGluR2 NAM) blocking. Small-animal PET studies indicated a low in vivo specific binding of [11C]1 in the rat brain. The brain uptake was increased in a P-glycoprotein and breast cancer resistant protein double knockout mouse, when compared to a wild-type mouse. While [11C]1 presented limited potential as an in vivo PET tracer for mGluR2, we suggested that it can be used as a lead compound for developing new radiotracers with improved in vivo brain properties.

Here is just a brief introduction to this compound(1452-77-3)Formula: C6H6N2O, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 1452-77-3. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Characterization of pyridine biodegradation by two Enterobacter sp. strains immobilized on Solidago canadensis L. stem derived biochar. Author is Nie, Zimeng; Yan, Binghua; Xu, Yunhai; Awasthi, Mukesh Kumar; Yang, Haijun.

In this study, two pyridine-degrading strains namely Enterobacter cloacae complex sp. BD17 and Enterobacter sp. BD19 were isolated from the aerobic tank of a pesticide wastewater treatment plant. The mixed bacteria H4 composed of BD17 and BD19 at a ratio of 1:1 was immobilized by Solidago canadensis L. stem biochar with a dosage of 2 g·L–1. The highest pyridine removal rate of 91.70% was achieved by the immobilized H4 at an initial pyridine concentration of 200 mg·L-1, pH of 7.0, temperature of 28°C and salinity of 3.0% within 36 h. The main intermediates of pyridine degradation by BD17 were pyridine-2-carboxamide, 2-aminopropanediamide, and 2-aminoacetamide, while 2-picolinic acid, iso-Pr acetate, iso-Pr alc., and acetaldehyde were identified with BD19 by adopting GC-MS technique. Interestingly, there was a possibility of totally mineralization of pyridine and the corresponding degradation pathways of BD17 and BD19 were revealed for the first time.

Here is just a brief introduction to this compound(1452-77-3)Related Products of 1452-77-3, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactivity of neutral platinum(II) complexes. Author is Panasyuk, V. D.; Malashok, N. F..

Kinetic data were obtained for the hydrolysis of [PtenCl2], cis- and trans-[Pt(NH3)2Cl2], cis-[Ptpy2Cl2], and [Pten(NO2)Cl] and for the replacement of Cl by NH3 in trans-[Pt(NH3)2Cl2]. The medium was H2O and mixtures of H2O with MeOH, EtOH, or Me2CO, the concentration of the organic component being 30 and 40 weight % in the hydrolysis and replacement reactions, resp. The lowering of the reaction rate in the presence of the organic component is explained by a structure-dependent contribution of the component to the solvation energy of an intermediate complex. The hydrolysis reaction is assumed to proceed in 2 steps: (1) formation of an intermediate complex by a slow coordination of the H2O mol. to the Pt2+ central ion without release of Cl- and (2) by a quick release of Cl-. The bond polarization occurs during the 1st step and the rate constant, k, should equal the ratio of the activity coefficients of the initial and activated complexes.

Here is just a brief introduction to this compound(15227-42-6)SDS of cas: 15227-42-6, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5 ) is researched.Safety of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole.Diab, Sarah; Yu, Mingfeng; Wang, Shudong published the article 《CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?》 about this compound( cas:882562-40-5 ) in Journal of Medicinal Chemistry. Keywords: review pharmacophore CT7001 SY1365 antitumor CDK7 cancer. Let’s learn more about this compound (cas:882562-40-5).

A review. Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to reduced cell proliferation. Importantly, it is now agreed that targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without causing an outage of transcription of housekeeping genes. Thus, CDK7 has been considered as a viable therapeutic target in cancer. Indeed, the development of CDK7 inhibitors has gained huge momentum with two mols., CT7001 and SY-1365, currently under clin. development. Herein, we discuss the latest understanding of the role of CDK7 in cancer cells and provide an overview of the pharmacophores of CDK7 inhibitors, their efficacy in various cancer models, and their clin. development.

Here is just a brief introduction to this compound(882562-40-5)Safety of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, more information about the compound(3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem