Heterocyclic Building Blocks-Tetrahydroisoquinoline

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Neorganicheskoi Khimii called Cis-bis(pyridine)dichloro derivatives of platinum(IV), Author is Chernyaev, I. I.; Zheligovskaya, N. N.; Bavina, T. V., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Reference of cis-Dichlorobis(pyridine)platinum(II).

The complexes Pt(py)2Cl2XNO2 (X = Cl-, Br-) and Pt(py)2Cl2(OH)NO2 were precipitated by adding 5-10 ml. H2O to mixtures of equivalent amounts of Pt(py)2Cl2(NO2)NO3 (I) and KCl, KBr, or KOH, resp. I reacts with KI to give a mixture of Pt(py)2Cl2I2 and Pt(py)2Cl2INO2. Chlorination of Pt(py)2Cl2 yields [Pt(py)2Cl2]Cl2. [Pt(py)2Cl2][Pt(py)2Cl2(OH)2] was obtained from Pt(py)2Cl2 and 10% aqueous H2O2 at room temperature after standing for 24 hrs. Individual species were identified by x-ray diffraction tests. The aqueous solutions of Pt(py)2Cl2XNO2 undergo hydrolysis according to: Pt(py)2Cl2XNO2 + H2O ⇌ [Pt(py)2Cl2X(H2O)]+ + NO2-, whereas the aqueous solutions of Pt(py)2Cl2(OH)2 and [Pt(py)2Cl2]Cl2 are considerably more stable. Solutions of Pt(py)2Cl2Br2 partially decompose in light to Pt(py)2Cl2, HBrO, and HBr, resp.

Here is just a brief introduction to this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Amidation of aldehydes using mono-cationic half-sandwich rhodium(III) complexes with functionalized phenylhydrazone ligands.SDS of cas: 1452-77-3.

A series of mono-cationic half-sandwich rhodium(III) complexes have been synthesized in methanol using phenylhydrazone-derived ligands (L1-L6) and the starting precursor [(η5-C5Me5)2Rh2(μ-Cl)2Cl2] in a 2:1 molar ratio. The N,N’-phenylhydrazone complexes have been isolated as tetraphenylborate salts. All complexes were characterized by elemental anal., FT-IR, UV-visible, NMR spectroscopy and mass spectrometry. The mol. structure of complex [(η5-C5Me5)Rh(L1)Cl](BPh4) (1) was confirmed by single-crystal X-ray structure anal. Complex [(η5-C5Me5)Rh(L3)Cl](BPh4) (3) was used as an efficient catalyst for the amide formation reaction, with up to 99% conversion after 2 h in toluene at 110 °C in the presence of hydroxyl amine hydrochloride and sodium bicarbonate.

Here is just a brief introduction to this compound(1452-77-3)SDS of cas: 1452-77-3, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M. published the article 《Prophage induction and mutagenicity of a series of antitumor platinum(II) and platinum(IV) coordination complexes》 about this compound( cas:15227-42-6 ) in Mutation Research. Keywords: antitumor platinum compound mutagenesis; prophage induction antitumor platinum compound. Let’s learn more about this compound (cas:15227-42-6).

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

Here is just a brief introduction to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Spectral and structural properties of the crystalline complex dichlorodi(pyridine)palladium, the main research direction is IR Raman palladium pyridine chloride.Related Products of 15227-42-6.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

Here is just a brief introduction to this compound(15227-42-6)Related Products of 15227-42-6, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Buniya, Meaad K.; Mohammad, Abdulkarim-Talaq; Al-Majidi, Suaad Mohammed Husain published the article 《Antibacterial studies of some novel Schiff base compounds》. Keywords: aminomethyl benzyliminomethyl phenyl alkoxybenzoate Schiff base preparation antibacterial.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Recommanded Product: 1-Bromoundecane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

A new series of 4-(((4-(aminomethyl)benzyl)imino)methyl)Ph 4-(alkyloxy)benzoates I [R = n-hexyl, n-octyl, n-tetradecyl, etc.] were synthesized and characterized. The condensation reaction of 4-formylphenyl 4-(alkyloxy)benzoate with 1,4-bis(aminomethyl)benzene yielded the title Schiff base compounds I. Titled compounds I containing a terminal alkoxy chain range from n = 6-14 carbon atoms. FT-IR and multinuclear-NMR were used to determine the structures of target compounds I. Compounds I were subjected antimicrobial studies found to have significant activity against the selected bacterial under study.

Here is just a brief introduction to this compound(693-67-4)Recommanded Product: 1-Bromoundecane, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Dibromogallates as a new building block for controlling pi-stacking, network formation and mirror symmetry breaking, the main research direction is dibromogallate liquid crystalline phase transition lattice parameter.Application In Synthesis of 1-Bromoundecane.

Achiral multi-chain (polycatenar) compounds based on the 2,7-di-Ph substituted [1]benzothieno[3,2-b]benzothiophene (BTBT) unit and a 2,6-dibromo-3,4,5-trialkoxybenzoate end group lead to materials forming bicontinuous cubic liquid crystalline phases with helical network structures over wide temperature ranges.

Here is just a brief introduction to this compound(693-67-4)Application In Synthesis of 1-Bromoundecane, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Synthetic Route of C10H10Cl2N2Pt. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Infrared spectroscopic study of dicyanato complexes of platinum. Author is Kharitonov, Yu. Ya.; Evstaf’eva, O. N.; Baranovskii, I. B.; Mazo, G. Ya..

trans-[Pt(NH3)2(CN)2] (I), trans-[Pt(ND3)2(CN)2], trans-Pt(NH3)2(CN)2.AgNO3, trans-[Pt(NH3)2(CN)2X2] (II) where X = Cl, Br, I, or OH, trans-[Pt(ND3)2(CN)2X2] where X = Br or I, cis-[PtA(CN)2] where A = (NH3)2, (pyridine)2, ethylenediamine, or (thiourea)2, cis-[Pten(CN)2X2] where X is Br or OH were studied by ir spectroscopy. Maximum of these compounds are tabulated. On oxidation of Pt, the νpt-CN did not change while νC-N increased ∼40-70 cm.-1 All trans complexes had a singlet and all cis had a doublet νCN. The split for cis complexes was larger for Pt(II) than for Pt(IV). The force constant of the C-N bond changed insignificantly, especially in Pt(II) complexes, on transition from ionic to covalent cyanides. Apparently the σ-bond contribution is larger in Pt(IV) than in Pt(II) complexes. When I was oxidized to II (X = Br) and, this subsequently became reduced, the product obtained was identical with the starting material. The complexes did not rearrange on oxidation and the nature of the X in II did not affect the Pt-N bonds. The νPt-N of trans isomers were at ∼525-31 cm.-1 for Pt(II) or Pt(IV). For the complexes studied, the overall (σ + π) bond strength of Pt-N was approx. the same in Pt(II) and Pt(IV) complexes.

Here is just a brief introduction to this compound(15227-42-6)Synthetic Route of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Heterocyclic Chemistry called Synthesis and pancreatic lipase inhibitory activities of some 1,2,4-triazol-5(3)-one derivatives, Author is Ozdemir, Yusuf; Bekircan, Olcay; Baltas, Nimet; Mentese, Emre, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Reference of 1-Bromoundecane.

In this study, starting from 4-amino-5-(4-chlorobenzyl)-2,4-dihydro-3H-1,2,4-triazole-3-one, the 4-Amino-5-(4-chlorobenzyl)-2-undecyl-2,4-dihydro-3H-1,2,4-triazol-3-one was first synthesized and this compound was converted to Schiff base derivatives I [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl]. In the second step of the study, the 2-[3-(4-chlorobenzyl)-5-oxo-1-undecyl-1,5-dihydro-4H-1,2,4-triazole-4-yl]-acetohydrazide, which was used as a key product in the synthesis of many heterocyclic compounds was synthesized in four steps, and then this compound was converted into methylidene acetohydrazide II [R = 4-F, 4-Cl, 2,4-di-F, 2,4-di-Cl, 2-F-4-Cl], thiosemicarbazide III [R2 = Me, Et, Ph, Bn, 4-ClC6H4], and 1,2,4-triazole-5-thione IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = H] derivatives Also, in the last part of the study, 1,2,4-triazole-5-thione derivatives were changed into Mannich bases IV [R2 = Me, Et, Ph, Bn, 4-ClC6H4; R3 = (4-phenylpiperazin-1-yl)methyl] bearing a 4-phenylpiperazine ring. These new compounds I, II, III and IV were tested with regard to pancreatic lipase (PL) inhibition activity, and compound I [R = 4-Cl, 2,4-di-Cl], II [R = 2,4-di-Cl], III [R2 = Ph] and IV [R2 = Ph; R3 = H] showed a considerable anti-lipase activity at various concentrations The activity of compounds II [R = 4-Cl] (IC50 = 1.45 ± 0.12μM) was the highest in terms of IC50, comparable to that of orlistat, a well-known PL inhibitor used as an antiobesity drug.

Here is just a brief introduction to this compound(693-67-4)Reference of 1-Bromoundecane, more information about the compound(1-Bromoundecane) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: Picolinamide. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Silica supported potassium oxide catalyst for dehydration of 2-picolinamide to form 2-cyanopyridine. Author is Li, Yamei; Zhao, Yujun; Wang, Shengping; Ma, Xinbin.

The dehydration of 2-picolinamide to produce 2-cyanopyridine was investigated thoroughly using silica supported potassium oxide as a heterogeneous catalyst. Both large sp. surface area and pore size of SiO2 (B) contributed to the favorable catalytic performance for the synthesis of 2-CP. In addition, the yield of 2-CP showed the linear relationship with the amounts of medium basicity of the catalysts, demonstrating that medium basic sites were the active sites of silica supported potassium oxide catalysts. The catalysts were further characterized by XRD and FT-IR to clarify the active species. The results indicated the Si-O-K group produced by the reaction of K2CO3 with Si-OH was the active species, which was further evidenced by the adjustment of the amount of Si-OH by silylation and hydroxylation procedure.

Here is just a brief introduction to this compound(1452-77-3)Name: Picolinamide, more information about the compound(Picolinamide) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Quantitative measurement of the reduction of platinum(iv) complexes using X-ray absorption near-edge spectroscopy (XANES), published in 2012, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

The platinum(ii) drugs cisplatin, carboplatin and oxaliplatin are usefully employed against a range of malignancies, but toxicities and resistance have spurred the search for improved analogs. This has included investigation of the platinum(iv) oxidation state, which provides greater kinetic inertness. It is generally accepted that Pt(iv) complexes must be reduced to Pt(ii) for activation. As such, the ability to monitor reduction of Pt(iv) complexes is critical to guiding the design of candidates, and providing mechanistic understanding. Here we report in full that the white line height of X-ray absorption near-edge spectra (XANES) of Pt complexes, normalized to the post-edge min., can be used to quant. determine the proportion of each oxidation state in a mixture A series of Pt(iv) complexes based on the Pt(ii) complexes cisplatin and transplatin were prepared with chlorido, acetato or hydroxido axial ligands, and studies into their reduction potential and cytotoxicity against A2780 human ovarian cancer cells were performed, demonstrating the relationship between reduction potential and cytotoxicity. Anal. of white line height demonstrated a clear and consistent difference between Pt(ii) (1.52 ± 0.05) and Pt(iv) (2.43 ± 0.19) complexes. Reduction of Pt(iv) complexes over time in cell growth media and A2780 cells was observed by XANES, and shown to correspond with their reduction potentials and cytotoxicities. We propose that this method is useful for monitoring reduction of metal-based drug candidates in complex biol. systems.

Compound(15227-42-6)Recommanded Product: cis-Dichlorobis(pyridine)platinum(II) received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(cis-Dichlorobis(pyridine)platinum(II)), if you are interested, you can check out my other related articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem