Tag: 151838-62-9

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151838-62-9,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 23 A. Podophyllotoxin-4-O-ester of N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid [000302] ; The mixture of podophyllotoxin (20 mg, 0.048 mmol), N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid (22 mg, 0.07 mmol), EDCI (25 mg, 0.13 mmol), DMAP (2 mg, 0.02 mmol) and dichloromethane (3 ml) were stirred in the room temperature for 20 h, then dichloromethane (20 ml) was added to the solution. Organic layer was washed with water (20 ml), saturated NaHCO3 aqueous solution (10 ml) and brine (20 ml), and then dried over MgSO4. After the solvent was removed under reduced pressure, the resulting liquid was separated by column chromatography (eluent: ethyl acetate and petroleum ether) to afford 15 mgPodophyllotoxin-4-O-ester of N-BOC-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid. [0242] The chemical structure analysis was performed by 1HNMR (CDCl3, 600 MHz):, 151838-62-9

As the paragraph descriping shows that 151838-62-9 is playing an increasingly important role.

Reference£º
Patent; Yang, Li-Xi; US2005/4169; (2005); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

151838-62-9, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,151838-62-9

Step 1 3(R)-Carboethoxy-1,2,3,4-tetrahydroisoquinoline The title compound was obtained from N-Boc-D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Bachem) using standard amino acid chemical procedures.

As the paragraph descriping shows that 151838-62-9 is playing an increasingly important role.

Reference£º
Patent; Merck & Co., Inc.; US5977134; (1999); A;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151838-62-9,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

To solution of 1- (2-allyl-4-benzyloxy-pyrrolidin-I-yi)-2-amino-3- (4-fluorophenyl)-propan-I-one, 54, (1.4 mmol) is dissolved in DMF (10 mL) are added N-Boc-tetrahydroisoquinoline-3-carboxylic acid (0.47g, 1.5 mmol), 1-hydroxybenzotriazole (0.43g, 2.8 mmol), N-methylmorpholine (0.84g, 8.3 mmol) and 1- (3-dimethylamino-propyl)-3-ethylcarbodiimide (0.32g, 1.7 mmol) at 0 C. The reaction mixture is stirred at 0 C for 1 hour and then warmed to room temperature and stirred an additional 1.5 hour. The reaction is quenched with saturated NH4CI solution and then extracted 3 times with EtOAc (70 mL). The organic layers are combined, washed with saturated NaCI solution, dried over Na2SO4, and the solvent is removed in vacuo. The crude product is purified over silica to afford 0.69 g (77% yield) of the desired product as a white solid.’H NMR (300 MHz, MeOD, Rotamers) 5 6.90-7. 41 (m, 13H), 5.55-5. 81 (m, 1 H), 4.32-5. 12 (m, 8H), 3.94-4. 18 (m, 2H), 2.75-3. 89 (m, 6H), 2.39-2. 64 (m, 1 H), 1.78-2. 29 (m, 2H), 1.20-1. 64 (m, 10H) ; MS (ESMS) m/z 642.2 (M+H) +.

The synthetic route of 151838-62-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE PROCTER & GAMBLE COMPANY; WO2004/37797; (2004); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

151838-62-9, 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2- {4- [2-AMINO-3- (4- FLUOROPHENYL)-PROPIONYL]-3-CYCLOPROPYLMETHYL-2-OXO-PIPERAZIN-1-YL}-N-METHYL-3-NAPHTHALEN-2-YL- propionamide, 18, (44 mg, 0. 068 MMOL) in DMF (1 mL) are added 3, 4-DIHYDRO-1H-ISOQUINOLINE- 2, 3-dicarboxylic acid 2-tert-butyl ester (21 mg, 0.079 MMOL), 1-HYDROXYBENZO-TRIAZOLE (20 mg, 0,148 mmol), N-methylmorpholine (41 mg, 0.41 MMOL) and 1- (3-DIMETHYLAMINO-PROPYL)-3- ETHYLCARBODIIMIDE (16 mg, 0.083 mmol) consecutively. The reaction mixture is stirred for 3 hours, quenched with aqueous NH4CI and extracted several times with ethyl acetate. The combined extracts are dried over NA2SO4, filtered and concentrated in vacuo to a residue, which is purified over silica gel (CH2CI2/CH30H, 13: 1) to afford the desired product.

151838-62-9 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 2735649, atetrahydroisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; THE PROCTER & GAMBLE COMPANY; WO2004/37797; (2004); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.151838-62-9,2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

The compound (6.27 g) of Example 27 (1) was dissolved in methylene chloride (50 mL), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (6.48 g) and n-pentylamine (3.1 mL) were successively added under ice-cooling, and the mixture was stirred at the same temperature for 1.5 hr. After the reaction mixture was washed successively with 10% aqueous citric acid solution and saturated brine, and dried over sodium sulfate. Then, methylene chloride was evaporated under reduced pressure. The obtained residue was dissolved in formic acid (20 mL), 10M hydrogen chloride – isopropanol solution (6.8 mL) was added under ice-cooling, and the mixture was stirred at the same temperature for 15 min. The reaction mixture was neutralized with saturated aqueous sodium hydrogen carbonate, extracted with ethyl acetate (50 mL), washed with saturated brine, and dried over sodium sulfate. Then, ethyl acetate was evaporated under reduced pressure. The obtained residue was washed with n-hexane, and the precipitate was collected by filtration to give a powder (2.58 g).

151838-62-9 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 2735649, atetrahydroisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Kyoto Pharmaceutical Industries, Ltd.; EP1857444; (2007); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem