226942-29-6, 6-Bromo-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of 6-bromo tetrahydroisoquinoline (300 mg, 1.42 mmol) in CH2Cl2 (8 mL) was cooled to 0 C, and i-Pr2NEt (243 mg, 1.88 mmol) and CbzCl (322 mg, 1.88 mmol) were added. The reaction was stirred at room temperature for 16 h. The reaction was diluted with CH2Cl2 (10 mL) and poured into water (20 mL). The layers were separated, and the aqueous layer was extracted with CH2Cl2 (3 x 20 mL). The combined organic layers were dried (Na2SO4) and concentrated under reduced pressure. The crude mixture was purified via flash column chromatography eluting with EtOAc:hexanes (5:95) to give 400 mg (81%) of 9 as a colorless oil: 1H NMR (400 MHz) delta 7.41 – 7.27 (comp, 7 H), 6.97 (d, J = 10.3 Hz, 1 H), 5.18 (s, 2 H), 4.59 (s, 2 H), 3.70 (br s, 2 H), 2.82 (br s, 2 H); HRMS (ESI) m/z C17H16BrNO2 (M+Na)+ calcd for 368.0257 and 370.0238; found 368.0257 and 370.0238.
As the paragraph descriping shows that 226942-29-6 is playing an increasingly important role.
Reference£º
Article; Linkens, Kathryn; Schmidt, Hayden R.; Sahn, James J.; Kruse, Andrew C.; Martin, Stephen F.; European Journal of Medicinal Chemistry; vol. 151; (2018); p. 557 – 567;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem