Tag: 312.2022

Sun, Zhaozhu et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2018 | CAS: 215184-78-4

tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity.COA of Formula: C14H18BrNO2

Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings was written by Sun, Zhaozhu;Zhou, Tian;Pan, Xuan;Yang, Ying;Huan, Yi;Xiao, Zhiyan;Shen, Zhufang;Liu, Zhanzhu. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.COA of Formula: C14H18BrNO2 This article mentions the following:

A novel series of GPR40 agonists is designed by introducing nitrogen-containing heterocyclic ring at the terminal Ph ring of TAK-875 (I) with the aim of decreasing its lipophilicity. Three different β-substituted phenylpropionic acids were investigated as the acidic components. A total of 34 compounds have been synthesized, among which, compound II exhibited comparable GPR40 agonistic activity in vitro with TAK-875 and relatively lower lipophilicity through calculation (II: EC50 = 1.2 μM, cLogP = 1.3; TAK-875: EC50 = 5.1 μM, cLogP = 3.4). Moreover, compound II was able to enhance the insulin secretion of primary islets isolated from normal ICR mice and showed no obvious inhibition against cytochromes P 450 in vitro. In vivo, compound II exhibited efficacy in oral glucose tolerance test (oGTT) in normal ICR mice. In the experiment, the researchers used many compounds, for example, tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4COA of Formula: C14H18BrNO2).

tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline motif is often present in natural products with a broad range of biological and pharmacological activities. The dopamine-derived tetrahydroisoquinolines (TIQ) synthesized endogeneously from aldehydes and catecholamines have shown to modulate neurotransmission, central metabolism and motor activity.COA of Formula: C14H18BrNO2

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ao, Na-Ri-Mei et al. published their research in Organic & Biomolecular Chemistry in 2021 | CAS: 215184-78-4

tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism.This is no longer generally accepted by the scientific community.Synthetic Route of C14H18BrNO2

Photocatalyzed Csp3-Csp3 cross-dehydrogenative coupling of N-Boc-tetrahydroisoquinolines with 伪,尾-unsaturated ketones was written by Ao, Na-Ri-Mei;Zhu, Xue-Qing;Zhao, Chun-Xin;Gao, Ya-Ru;Wang, Yong-Qiang. And the article was included in Organic & Biomolecular Chemistry in 2021.Synthetic Route of C14H18BrNO2 This article mentions the following:

A novel photocatalyzed cross-dehydrogenative coupling reaction of N-Boc-tetrahydroisoquinolines I [R1 = H, 5-Br, 7-O2N, 5,6-(MeO)2, etc.] with 伪,尾-unsaturated ketones MeC(O)CH:CHR2 (R2 = Ph, n-hexyl, PhCH2CH2, etc.) has been developed. This research provides an easy access to a variety of C1-substituted tetrahydroisoquinolines II, which could be further transformed into benzo[a]quinolizine-2-ones, the skeletons of natural products with a wide range of biol. activities. The load of the photocatalyst was low and the oxidant was inexpensive and less toxic. In the experiment, the researchers used many compounds, for example, tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4Synthetic Route of C14H18BrNO2).

tert-Butyl 5-bromo-3,4-dihydroisoquinoline-2(1H)-carboxylate (cas: 215184-78-4) belongs to tetrahydroisoquinoline derivatives. Tetrahydroisoquinoline, as a secondary amine, tetrahydroisoquinoline has weakly basic properties and forms salts with strong acids. Tetrahydroisoquinoline derivatives may be formed in the body as metabolites of some drugs, and this was once thought to be involved in the development of alcoholism.This is no longer generally accepted by the scientific community.Synthetic Route of C14H18BrNO2

Referemce:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem