Tag: 33537-99-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.33537-99-4,6-Chloro-1,2,3,4-tetrahydroisoquinoline,as a common compound, the synthetic route is as follows.

To a stirring solution of 23 (1 mmol, 200mg) in dichloromethane and triethylamine15 (2mmol, 0.3ml) at room temperature was added N-bromosuccinimide (1.1rhmol,200mg). The reaction mixture was stirred at room temperature for 30min. Then2.0 M NaOH aqueous solution was added and the reaction mixture was stirred atrt for another 1 h. The reaction mixture as extracted with DCM. The combinedorganic layer was over MgS04 . The solvent was removed in vacuo. The crude20 product 24 was used in the next step without further purification

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Reference£º
Patent; MERCK SHARP & DOHME CORP.; MA, Yao; SHIZUKA, Manami; GUZI, Timothy, J.; LIU, Yuan; TIAN, Yuan; LAHUE, Brian, R.; GIBEAU, Craig, R.; SHIPPS, Gerald, W., Jr.; WANG, Yaolin; BOGEN, Stephane, L.; NAIR, Latha, G.; PAN, Weidong; VOSS, Matthew, E.; KIROVA-SNOVER, Margarita; CLAYTON, W. Brent; MCCOY, Mark, A.; WO2013/96150; (2013); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

33537-99-4, 6-Chloro-1,2,3,4-tetrahydroisoquinoline is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of (/:?)-A/-(3-aminobutyl)-4-(dimethylamino)benzenesulfonamide (0.88 g, 4.0 mmol) in CH3CN (10 ml.) was added 6-chloro-1 ,2,3,4-tetrahydroisoquinoline (1.98 g, 4.0 mmol). The reaction mixture was stirred at ambient temperature overnight. The mixture was concentrated and the residue was purified by column chromatography to provide (/:?)-6-chloro-A/-(4-(4-(dimethylamino)phenylsulfonamido)butan-2-yl)-3,4- dihydroisoquinoline-2(1 /-/)-sulfonamide.

The synthetic route of 33537-99-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; KEZAR LIFE SCIENCES; JOHNSON, Henry; (166 pag.)WO2019/178510; (2019); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem