Tag: 877861-62-6

877861-62-6, Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride is a tetrahydroisoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

877861-62-6, Step 1 : Preparation of 2-(1 ,1-dimethylethyl) 6-methyl 3,4-dihvdro-2,6(1/-/)-isoquinoline- dicarboxylate; To a solution of methyl 1 ,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride(0.30 g, 1.32 mmol) in dioxane/H2O (2:1 , 5 ml.) was added 1 N NaOH (1.97 ml_, 1.97 mmol) followed by BoC2O (0.43 g, 1.97 mmol). The reaction was stirred at room temperature for 1 hour, at which time LCMS indicated complete conversion to product.The reaction was poured into H2O (10 ml.) and extracted with CH2CI2 (3×10 ml_). The organics were dried (Na2SO4) and evacuated. The crude carbamate was used directly in the next step.

As the paragraph descriping shows that 877861-62-6 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/49154; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.877861-62-6,Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Intermediate 67; Methyl 2-(phenylmethyl)-1,2,3.4-tetrahvdro-6-isoquinolinecarboxylate; To a solution of methyl 1 ,2,3,4-tetrahydro-6-isoquinolinecarboxylate hydrochloride (230 mg, 1.01 mmol) in ethanol (10 ml) was added triethylamine (380 mul, 2.02 mmol) and (bromomethyl)benzene (120 mul, 1.01 mmol). The reaction mixture was stirred at room temperature overnight. The mixture was concentrated and the residue was diluted with a saturated solution of NaHCO3 and dichloromethane. The organic phase was extracted, dried over Na2SO4, filtered and concentrated to give the title compound as yellow oil (260 mg, 86%). LC/MS : m/z 282 (M+H)+, Rt: 3.47.

As the paragraph descriping shows that 877861-62-6 is playing an increasingly important role.

Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/47240; (2009); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.877861-62-6,Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

A mixture of methyl 1,2,3,4-tetrahydroisoquino- line-6-carboxylate hydrochloride (230 mg, 1.01 mmol), bromobenzene (230 mg, 1.47 mmol), and cesium carbonate (0.66 g, 2.02 mmol) in 1,4-dioxane (10 mE) was purged with nitrogen. RuPhos precatalyst (15mg, 0.020 mmol) was added and the reaction mixture was heated at 80 C. for 30 mm, then 120 C. for 16 h. The solvent was removed under vacuum. The residue was diluted with water (30 mE), poured into a separatory flannel, and washed with ethyl acetate (3×50 mE). The combined organic layers were dried over sodium sulfate and the solvent was removed under vacuum and the crude mixture was purified on silica gel using a gradient of 0-100% ethyl acetate/hexanes, to give methyl 2-phenyl-1 ,2,3,4-tet- rahydroisoquinoline-6-carboxylate(200mg, 74%). 1HNMR (400 MHz, CDC13) oe 8.00-7.76 (m, 2H), 7.30-7.12 (m, 3H), 6.75 (d, 2H), 6.75 (t, 1H), 4.35 (s, 2H), 3.84 (s, 3H), 3.39 (t, 2H), 2.94 (t, 2H) ppm. LCMS: (ESI) mlz 268 [M+H].

The synthetic route of 877861-62-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Forma Therapeutics, Inc.; Ioannidis, Stephanos; Talbot, Adam Charles; Follows, Bruce; Buckmelter, Alexandre Joseph; Wang, Minghua; Campbell, Ann-Marie; Schmidt, Darby Rye; Guerin, David Joseph; Caravella, Justin A.; Diebold, R. Bruce; Ericsson, Anna; Lancia, JR., David; (225 pag.)US2016/185785; (2016); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.877861-62-6,Methyl 1,2,3,4-tetrahydroisoquinoline-6-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

Methyl 1 ,2,3,4-tetrahydro-6-isoquinolinecarboxylate hydrochloride (3.071 g, 13.5mmol), BOC-anhydride (4.42g, 20.3mmol) and triethylamine (3.76ml, 27.0mol) were stirred in DCM (70ml) under argon for 18 hours, evaporated to dryness, redissolved in ethyl acetate, washed with saturated sodium bicarbonate twice, once with brine and dried (MgSO4). The organic solution was filtered, evaporated to a solid and purified by flash chromatography using ethyl acetate and hexane to yield the title compound (3.6g) LC/MS Rt = 3.24min [MH+] 236

The synthetic route of 877861-62-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2006/114313; (2006); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem