Tag: M.W:100-200

Electric Literature of C6H6N2O. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Crystal structures of three N-(pyridine-2-carbonyl)pyridine-2-carboxamides as potential ligands for supramolecular chemistry.

The synthesis and single-crystal X-ray structures of three N-(pyridine-2-carbonyl)pyridine-2-carboxamide imides, with or without F atoms on the 3-position of the pyridine rings are reported, namely, N-(pyridine-2-carbonyl)pyridine-2-carboxamide, C12H9N3O2 (1), N-(3-fluoropyridine-2-carbonyl)pyridine-2-carboxamide, C12H8FN3O2 (2), and 3-fluoro-N-(3-fluoropyridine-2-carbonyl)pyridine-2-carboxamide, C12H7F2N3O2 (3). The above-mentioned compounds were synthesized by a mild, general procedure with an excellent yield, providing straightforward access to sym. and/or asym. heterocyclic ureas. The crystal structures of 1 and 2 are isomorphous, showing similar packing arrangements, i.e. double layers of parallel (face-to-face) mols. alternating with analogous, but perpendicularly oriented, double layers. In contrast, the crystal structure of 3, containing a fluoro- group at the 3-position of both pyridine rings, shows mol. arrangements in a longitudinal, tubular manner along the c axis, with the aromatic pyridine and carbonyl/fluorine moieties facing towards each other.

The article 《Crystal structures of three N-(pyridine-2-carbonyl)pyridine-2-carboxamides as potential ligands for supramolecular chemistry》 also mentions many details about this compound(1452-77-3)Electric Literature of C6H6N2O, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Wang, Hai; Wang, Liang; Wang, Sai; Dong, Xue; Zhang, Jian; Xiao, Feng-Shou published the article 《Aerobic Activation of C-H Bond in Amines Over a Nanorod Manganese Oxide Catalyst》. Keywords: aerobic activation amine nanorod manganese oxide catalyst; amide preparation green chem.They researched the compound: Picolinamide( cas:1452-77-3 ).Application of 1452-77-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

The development of heterogeneous catalysts for the synthesis of pharmaceutically relevant compounds is always important for chem. research. Here, we report a selective aerobic oxidation of aromatic and aliphatic amines to corresponding amides over a nanorod manganese oxide (NR-MnOx) catalyst. The kinetic studies reveal that the NR-MnOx catalyzed amine-to-amide reaction proceeds the oxidative dehydrogenation of the amines into nitriles, followed by hydrolysis of nitrile into amides. The NR-MnOx exhibits fast kinetics and high selectivities in these steps, as well as hinders the byproduct formation. More importantly, the NR-MnOx catalyst is stable and reusable in the continuous recycle tests with water as a sole byproduct, exhibiting superior sustainability and significant advancement to outperform the traditional amide production route in acidic or basic media with toxic byproducts.

Different reactions of this compound(Picolinamide)Application of 1452-77-3 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 1452-77-3. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Lewis acid promoted dehydration of amides to nitriles catalyzed by [PSiP]-pincer iron hydrides. Author is Chang, Guoliang; Li, Xiaoyan; Zhang, Peng; Yang, Wenjing; Li, Kai; Wang, Yajie; Sun, Hongjian; Fuhr, Olaf; Fenske, Dieter.

The dehydration of primary amides to their corresponding nitriles using four [PSiP]-pincer hydrido iron complexes [(2-Ph2PC6H4)2MeSiFe(H)(PMe3)2, (2-Ph2PC6H4)2HSiFe(H)(PMe3)2, (2-(iPr)2PC6H4)2HSiFe(H)(PMe3)2 and (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2] as catalysts in the presence of (EtO)3SiH as dehydrating reagent was explored in the good to excellent yields. It was proved for the first time that Lewis acid could significantly promote this catalytic system under milder reaction conditions than other Lewis acid-promoted system, such as shorter reaction time or lower reaction temperature This was also the first example that dehydration of primary amides to nitriles RCN [R = 4-ClC6H4, 2-thienyl, Bn, etc.] was catalyzed by silyl hydrido iron complexes bearing [PSiP]-pincer ligands with Lewis acid as additive. This catalytic system had good tolerance for many substituents. Among the four iron hydrides (2-Ph2PC6H4)2MeSiFe(H)(PMe3)2 was the best catalyst. The effects of substituents of the [PSiP]-pincer ligands on the catalytic activity of the iron hydrides were discussed. A catalytic reaction mechanism was proposed. Complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was a new iron complex and was fully characterized. The mol. structure of complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was determined by single crystal X-ray diffraction.

The article 《Lewis acid promoted dehydration of amides to nitriles catalyzed by [PSiP]-pincer iron hydrides》 also mentions many details about this compound(1452-77-3)SDS of cas: 1452-77-3, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation, the main research direction is iron proteins Synechocystis nitrogen fixation transcriptome; Co-expression networks; GO and KEGG analysis; Iron deficiency; Synechocystis sp. PCC 6803; WGCNA.HPLC of Formula: 1452-77-3.

Iron is a common cofactor in biol. processes such as respiration, photosynthesis, and nitrogen fixation. The genes isiC and isiD encode unknown proteins, and the growth of ΔisiC and ΔisiD mutants is inhibited under iron-deficient conditions. To study the regulatory mechanisms of IsiC and IsiD during iron starvation, we carried out transcriptome and metabolome sequencing. The Kyoto Encyclopedia of Genes and Genomes (KEGG) anal. showed that the photosynthesis, nitrogen metabolism, and ABC transporter pathways play a vital role in regulating iron deficiency. Upon iron repletion, IsiC and IsiD also have a regulatory effect on these pathways. Addnl., KEGG anal. of the differential metabolites of wild type (WT) and mutants showed that they were all enriched in starch and sucrose metabolism after iron limitation. Weighted gene co-expression network anal. (WGCNA) constructed a co-expression network of differentially expressed genes with phenotypes and metabolites, and finally identified five modules. The turquoise module was pos. correlated with iron deficiency. In contrast, the WT and blue module exhibited a neg. correlation, and the mutants ΔisiC and ΔisiD were pos. correlated with the gray and brown modules, resp. WGCNA also analyzed the relationship between metabolites and phenotypes, and the green module was related to iron starvation. The co-expression network determined the hub genes and metabolites of each module. This study lays a foundation for a better understanding of cyanobacteria in response to iron deficiency.

The article 《New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation》 also mentions many details about this compound(1452-77-3)HPLC of Formula: 1452-77-3, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation, the main research direction is iron proteins Synechocystis nitrogen fixation transcriptome; Co-expression networks; GO and KEGG analysis; Iron deficiency; Synechocystis sp. PCC 6803; WGCNA.SDS of cas: 1452-77-3.

Iron is a common cofactor in biol. processes such as respiration, photosynthesis, and nitrogen fixation. The genes isiC and isiD encode unknown proteins, and the growth of ΔisiC and ΔisiD mutants is inhibited under iron-deficient conditions. To study the regulatory mechanisms of IsiC and IsiD during iron starvation, we carried out transcriptome and metabolome sequencing. The Kyoto Encyclopedia of Genes and Genomes (KEGG) anal. showed that the photosynthesis, nitrogen metabolism, and ABC transporter pathways play a vital role in regulating iron deficiency. Upon iron repletion, IsiC and IsiD also have a regulatory effect on these pathways. Addnl., KEGG anal. of the differential metabolites of wild type (WT) and mutants showed that they were all enriched in starch and sucrose metabolism after iron limitation. Weighted gene co-expression network anal. (WGCNA) constructed a co-expression network of differentially expressed genes with phenotypes and metabolites, and finally identified five modules. The turquoise module was pos. correlated with iron deficiency. In contrast, the WT and blue module exhibited a neg. correlation, and the mutants ΔisiC and ΔisiD were pos. correlated with the gray and brown modules, resp. WGCNA also analyzed the relationship between metabolites and phenotypes, and the green module was related to iron starvation. The co-expression network determined the hub genes and metabolites of each module. This study lays a foundation for a better understanding of cyanobacteria in response to iron deficiency.

The article 《New insights into the function of the proteins IsiC and IsiD from Synechocystis sp. PCC 6803 under iron limitation》 also mentions many details about this compound(1452-77-3)SDS of cas: 1452-77-3, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 61302-99-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: D-Alanine methylamide hydrochloride, is researched, Molecular C4H11ClN2O, CAS is 61302-99-6, about New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity. Author is Kazmierski, Wieslaw M.; Urbanczyk-Lipkowska, Zofia; Hruby, Victor J..

The synthesis of all four diastereoisomers of α,β-dimethylphenylalanine, H2NCMe(CHMePh)CO2H, (4) as well as those of α,β-dimethyl-1,2,3,4,-tetrahydroisoquinoline-3-carboxylic acid (I and II) have been accomplished in high yield and high optical purity. Mol. mechanics calculations on the Nα-acetyl and N-methylcarboxamide derivatives of (3R,4R)-I and (3R,4S)-II indicate large and moderate energy stabilization for the gauche(-) but not the gauche(+) side-chain conformers of (3R,4S)-II and (3R,4R)-I, resp. By symmetry rules, the same holds for (3S,4R)-II and (3S,4S)-I, resp. Thus, these amino acids are potential building blocks for the topog. design of peptides (W. M. Kazmierski et al., 1991) by providing acylated 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives in which a gauche(-) and not a gauche(+) side-chain conformation is energetically more stable for the L-amino acid. Synthetic details and implications of these new amino acids for peptide and protein design are discussed.

The article 《New Amino Acids for the Topographical Control of Peptide Conformation: Synthesis of All the Isomers of α,β-Dimethylphenylalanine and α,β-Dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid of High Optical Purity》 also mentions many details about this compound(61302-99-6)SDS of cas: 61302-99-6, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization, the main research direction is Fragment screening; Ligand-protein interaction; Molecular docking; RNA-binding proteins; SPR; STD-NMR.Application In Synthesis of Picolinamide.

Hu proteins are members of the RNA-binding protein (RBP) family and play a pivotal role in the regulation of post-transcriptional processes. Through interaction with selected mRNAs, RBPs regulate their function and stability; as a consequence, RBP dysregulation can cause abnormal translation of key proteins involved in several pathologies. In the past few years, this observation has sparked interest to develop new treatments against these pathologies by using small mols. able to modulate RBP activity. Among the four Hu proteins, we have directed our efforts towards the isoform HuR, which is mainly involved in cancer, inflammation and retinopathy. Aimed at developing compounds able to modulate the stability of HuR-mRNA complexes, in the present work, we applied a biophys. fragment screening by assessing a library of halogen-enriched heterocyclic fragments (HEFLibs) via Surface Plasmon Resonance (SPR) and Saturation Transfer Difference (STD) NMR to select promising fragments able to interact with HuR. One selected fragment and a few com. available congeners were exploited to design and synthesize focused analogs of compound N-(3-chlorobenzyl)-N-(3,5-dihydroxyphenethyl)-4-hydroxybenzamide (1), our previously reported hit. STD NMR spectroscopy, mol. modeling, and SPR offered further insight into the HuR-small mol. interaction and showed that fragment-based approaches represent a promising and yet underexplored strategy to tackle such unusual targets. Lastly, fluorescence polarization (FP) studies revealed the capability of the new compounds to interfere with the formation of the HuR-mRNA complex. This is, to our knowledge, the first fragment-based campaign performed on the Hu protein class, and one of the few examples in the larger RBP field and constitutes an important step in the quest for the rational modulation of RBPs and related RNA functions by small mols.

The article 《Identification of N,N-arylalkyl-picolinamide derivatives targeting the RNA-binding protein HuR, by combining biophysical fragment-screening and molecular hybridization》 also mentions many details about this compound(1452-77-3)Application In Synthesis of Picolinamide, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Organometallic Chemistry called Design of organoruthenium complexes for nanoparticle functionalization, Author is Kumar, Saawan; Gallician, Guillaume; Weidener, Dennis; Sullivan, Matthew P.; Sohnel, Tilo; Hanif, Muhammad; Hartinger, Christian G., which mentions a compound: 1452-77-3, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2O, Safety of Picolinamide.

In recent years, extensive research efforts have been focused on loading metal complexes onto macromol. systems such as nanoparticles. We report a ligand with a catechol group based on a picolinamide which allows for coordination to organoruthenium moieties while the catechol group remains available for loading on nanoparticles as delivery vehicles towards tumors. All the compounds were characterized with standard anal. methods and the mol. structure of the ligand 1, and its Ru complexes 1a and 1b were determined by X-ray diffraction anal. The crystal structure of 1a and 1b showed pseudo-tetrahedral geometry of the Ru center with “”piano-stool”” conformation and 1 coordinated as an N,O-bidentate ligand, however, the latter depending on the reaction conditions employed. The Ru complexes 1a-1c were effectively loaded on magnetite nanoparticles as characterized by inductively-coupled plasma mass spectrometry (ICP-MS), transmission electron microscopy (TEM) and Fourier transform IR spectroscopy (FTIR).

The article 《Design of organoruthenium complexes for nanoparticle functionalization》 also mentions many details about this compound(1452-77-3)Safety of Picolinamide, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Coupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst, the main research direction is methanol carbon dioxide cyanopyridine dimethyl carbonate.Recommanded Product: 1452-77-3.

The present work is aimed to produce di-Me carbonate by coupling of CH3OH and CO2 with 2-cyanopyridine over ZnO-CeO2 catalysts prepared by co-precipitation method. These catalysts were characterized by XRD, TEM, UV-Vis DRS, BET surface area, CO2 and NH3-TPD techniques and applied for the titled reaction. Among the investigated catalysts 10ZnO-90CeO2 catalyst with CeO2 crystallite size 8.0 nm exhibited 96% conversion of methanol with 99% selectivity to di-Me carbonate. The superior catalytic activity is a unified effect of crystalline size of CeO2 and presence of an optimum number of acidic and basic sites. This protocol offers enhanced conversion of methanol with the simultaneous conversion of 2-cyanopyridine into 2-picolinamide by removing water mols. formed in the reaction.

The article 《Coupling of CH3OH and CO2 with 2-cyanopyridine for enhanced yields of dimethyl carbonate over ZnO-CeO2 catalyst》 also mentions many details about this compound(1452-77-3)Recommanded Product: 1452-77-3, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: Picolinamide. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Magnetically enhanced polymersupported ceria nanocatalysts for the hydration of nitriles.

The heterogeneous catalysis of the hydration of nitriles to amides is a process of great industrial relevance in which cerium(IV) oxide (also referred to as ceria) has shown an outstanding catalytic performance. The use of non-supported ceria nanoparticles is related to difficulties in the purification of the product and the recovery and recyclability of the catalyst. Therefore, in this work, ceria nanoparticles are supported on a polymer matrix either by synthesizing polymer particles by so-called Pickering miniemulsions while using ceria nanoparticles as emulsion stabilizers or, as a comparison, by in-situ crystallization on preformed polymer particles. The former strategy presents significant advantages over the latter in terms of time and consumption of resources, and it facilitates an easier scale-up of the process. In both strategies, the incorporation of a magnetoresponsive core within the polymer matrix allows the recovery and the recycling of the catalyst by simple application of a magnetic field and offers an enhancement of the catalytic efficiency.

The article 《Magnetically enhanced polymersupported ceria nanocatalysts for the hydration of nitriles》 also mentions many details about this compound(1452-77-3)Recommanded Product: Picolinamide, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem