Tag: M.W:100-200

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 1745-07-9, molcular formula is C11H15NO2, introducing its new discovery. , 1745-07-9

Synthesis method of quinazolinone polycyclic compound (by machine translation)

The invention belongs to the technical field of organic synthesis and medicine. The invention particularly relates to a synthesis method of a quinazolinone polycyclic compound. The quinazolinone polycyclic compound is obtained by taking a benzisoxazole derivative and tetrahydroisoquinoline as a raw material without a solvent and any additive and reacting under the heating condition. With the adoption of the method provided by the invention, the quinazoline ketone derivative 1 can be obtained under the heating and stirring conditions under the heating and stirring conditions, and the yield of the quinazolinone derivative is in the range of from 75~96% about. The reaction is simple and easily available raw materials without any additives and solvents, one-step method is simple and rapid to synthesize quinazoline ketone derivatives, and a simple, efficient and green synthesis method is provided for the synthesis of quinazolinone derivatives. (by machine translation)

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, 1745-07-9, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 1745-07-9

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

1745-07-9, An article , which mentions 1745-07-9, molecular formula is C11H15NO2. The compound – 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline played an important role in people’s production and life.

A Photochemical Route to the Protoberberine Skeleton

Irradiation of Mannich bases obtained from phtalimides, formaldehyde, and 1,2,3,4-tetrahydroisoquinolines and carrying methoxy or methylenedioxy substituents gave, in moderate yield, pentacyclic photoproducts.These underwent acid-promoted reaction leading to 13-hydroxydibenzoquinolizin-8-ones, one of which was 13-hydroxy-8-oxoxylopinine.Reduction to remove the 8,13 oxygenated functions was not achieved.Unsymmetrical substrates derived from 3,4-dimethoxyphtalimide gave a mixture of regio- and stereo-isomers in photocyclisation, with no strong preference for one orientation of reaction.

1745-07-9, Interested yet? Read on for other articles about 1745-07-9!

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

42923-76-2, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 42923-76-2, name is 6-Methyl-1,2,3,4-tetrahydroisoquinoline. In an article£¬Which mentioned a new discovery about 42923-76-2

The remarkable effect of a simple ion: Iodide-promoted transfer hydrogenation of heteroaromatics

I can do it! Accelerated by simple iodide ions, rhodium-catalysed transfer hydrogenation can be readily performed on quinolines, isoquinolines and quinoxalines, affording the tetrahydro products in high yields with low catalyst loading (see scheme). Copyright

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 42923-76-2 is helpful to your research. 42923-76-2

Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1612-65-3, name is 2-Methyl-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery. 1612-65-3

Gold Catalyzed Photoredox C1-Alkynylation of N-Alkyl-1,2,3,4- tetrahydroisoquinolines by 1-Bromoalkynes with UVA LED Light

A synthetic method that combines [Au2(m-dppm)2]Cl2 (dppm=bis(diphenylphosphanyl)methane) and UVA LED (LED=light emitting diode) light (365 nm) to catalyze the regioselective C1-alkynylation of N-alkyl-1,2,3,4-tetrahydroisoquinolines (THIQs) with alkynyl bromides is described. The reaction mechanism was delineated to involve a reductive quench pathway to generate the two posited radical species of the nitrogen-containing heterocycle and organic halide. In contrast, radical formation via an oxidative quench pathway was suggested to be operative in analogous control experiments with a 1-iodoalkyne. The usefulness of this carbon-carbon bond forming strategy was also exemplified by its application to the formal synthesis of the opioid analgesic drug methopholine and synthesis of a protoberberine alkaloid derivative.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1612-65-3 is helpful to your research. 1612-65-3

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 43207-78-9. In a patent£¬Which mentioned a new discovery about 43207-78-9, molcular formula is C10H13NO, introducing its new discovery.

Heterocyclic derivatives and their use as antithrombotic agents

The present invention relates to antithrombotic compounds comprising the group Q, Q having formula (I), wherein the substructure (i) is a structure selected from (a, b and c), wherein X is O or S; X? being independently CH or N; and m is 0, 1, 2 or 3; wherein the group Q is bound through an oxygen atom or an optionally substituted nitrogen or carbon atom, or a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention are therapeutically active and in particular are antithrombotic agents.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 43207-78-9, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 43207-78-9

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In an article, published in an article,authors is Bojarski, Andrzej J., once mentioned the application of 33537-99-4, Name is 6-Chloro-1,2,3,4-tetrahydroisoquinoline,molecular formula is C9H10ClN, is a conventional compound. this article was the specific content is as follows. 33537-99-4

Substituted 2-(1,2,3,4-tetrahydroisoquinoline)-butyl derivatives of azaspiro[4.5]decane-7,9-dione and phthalimide as new 5-HT1a and 5-HT2a receptor ligands

Two series of 2-butyl-8-azaspiro[5,4]decane-7,9-dione (a) and N-phthalimidobutyl (b) derivatives of 1,2,3,4-tetrahydroisoquinoline (THIQ) were synthesized. The impact of substituent variations in the aromatic part of the THIQ moiety on 5-HT1A and 5-HT2A receptor affinities, as well as in vivo functional properties of the investigated compounds are discussed. It was found that those modifications improved 5-HT2A receptor affinity, but also slightly reduced the binding affinity for 5-HT1A receptors (in comparison with the unsubstituted THIQ derivatives 3a and 3b). The most active compound (8-Br,5-OCH3-THIQ – 8a) showed features of a 5-HT1A (postsynaptic)/5-HT2A receptor antagonist. Additionally, all chloro derivatives with high and equal affinity for 5-HT1A receptors revealed different functional properties, i.e. an agonistic activity of presynaptic 5-HT1A receptors (4a) and a partial agonistic activity of postsynaptic 5-HT1A receptors (4a, 6a) or an antagonistic activity of postsynaptic ones (5a).

If you are interested in 33537-99-4, you can contact me at any time and look forward to more communication. 33537-99-4

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

1745-07-9, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1745-07-9, name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline. In an article£¬Which mentioned a new discovery about 1745-07-9

Visible-light-induced direct alpha-C(sp3)-H thiocyanation of tertiary amines

Visible-light-induced, eosin Y catalyzed aerobic oxidative alpha-C(sp3)-H thiocyanation of tertiary amines is reported. The reaction proceeds through visible-light-induced in situ generation of the iminium ion followed by attack of -SCN nucleophile. This is the first example of visible-light-initiated formation of C(sp3)-S bond employing organo-photoredox catalysis. Mild reaction conditions and use of air and visible light as the greenest and sustainable reagents at room temperature are the salient features of the protocol.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1745-07-9 is helpful to your research. 1745-07-9

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

As a common heterocyclic compound, it belong tetrahydroisoquinoline compound,6-Methoxy-1,2,3,4-tetrahydroisoquinoline,42923-77-3,Molecular formula: C10H13NO,mainly used in chemical industry, its synthesis route is as follows.,42923-77-3

To a solution of 6-methoxy-l,2,3,4-tetrahydroisoquinoline (2.0 g, 12.3 mmol)in sulfuric acid (10 mL) at -5 C was slowly added guanidine nitrate (750 mg, 6.15 mmol) and the mixture was stirred for 15 min at the same temperature. The reaction was quenched with ice-cold water and basified using potassium carbonate. The aqueous mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to yield 1.7 g of the desired compound. lU NMR (400 MHz, DMSO-de) d 2.76 (t, J= 6.0 Hz, 2H), 2.94 (t, J= 6.0 Hz, 2H), 3.83 (d, J= 6.4 Hz, 2H), 3.87 (s, 3H), 7.07 (s, 1H), 7.60 (s, 1H), 8.32 (s, 1H).

With the synthetic route has been constantly updated, we look forward to future research findings about 6-Methoxy-1,2,3,4-tetrahydroisoquinoline,belong tetrahydroisoquinoline compound

Reference£º
Patent; ICHNOS SCIENCES S.A.; CHAUDHARI, Sachin, Sundarlal; GHARAT, Laxmikant, Atmaram; IYER, Pravin; DHONE, Sachin, Vasantrao; ADIK, Bharat, Gangadhar; WADEKAR, Prashant, Dilip; GOWDA, Nagaraj; BAJPAI, Malini; (233 pag.)WO2020/70331; (2020); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

As a common heterocyclic compound, it belongs to tetrahydroisoquinoline compound, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline, and cas is 42923-77-3, its synthesis route is as follows.,42923-77-3

EXAMPLE 74D /eri-butyl 6-methoxy-3,4-dihydroisoquinoline-2(l//)-carboxylate To a solution of EXAMPLE 74C (1.88 g, 11.5 mmol) in dichloromethane (40 mL) was added triethylamine (2.3 g, 23 mmol) and di-feri-butyl dicarbonate (3 g, 13.8 mmol). After stirring for 16 hours, the mixture was poured into water (50 mL) and extracted with dichloromethane (2 * 100 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered, concentrated and purified by flash chromatography on silica gel eluting with 10: 1 hexane :ethyl acetate to give the title compound. MS : 264 (M+HT).

With the complex challenges of chemical substances, we look forward to future research findings about 42923-77-3,belong tetrahydroisoquinoline compound

Reference£º
Patent; ABBOTT LABORATORIES; ABBOTT LABORATORIES TRADING (SHANGHAI) COMPANY, LTD.; VASUDEVAN, Anil; PENNING, Thomas Dale; CHEN, Huanming; LIANG, Bo; WANG, Shaohui; ZHAO, Zhongqiang; CHAI, Dikun; YANG, Leifu; GAO, Yingxiang; WO2012/97682; (2012); A1;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, cas is 57196-62-0, it is a common heterocyclic compound, the tetrahydroisoquinoline compound, its synthesis route is as follows.,57196-62-0

To an ice bath cooled mixture of 6-methoxy-1,2, 3, 4-tetrahydroisoquinoline hydrochloride salt from part a) (23 g, 115.2 [MMOL)] and triethylamine (48 mL) in dichloromethane (400 mL) was added [TRIFLUOROACETIC] anhydride (19.5 mL). The solution was stirred for 1 hour at room temperature before quenching with saturated sodium bicarbonate. The organic layer was removed, dried [(MGS04)] and purified by chromatography on silica eluting with 10% EtOAc/Hexane up to 30% EtOAc/Hexane yielding the title compound D16 as a clear oil (7.75 [G).] MH+ 260.’H NMR [8] (CDCI3) 2.88-2. 98 (2H, t), 3.74-3. 90 (5H, m), 4.63-4. 75 (2H, d), 6.65-6. 84 (2H, m), 7.01-7. 10 (1H, m).

57196-62-0 is used more and more widely, we look forward to future research findings about 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Reference£º
Patent; GLAXO GROUP LIMITED; WO2003/99786; (2003); A2;,
Tetrahydroisoquinoline – Wikipedia
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem