Tag: M.W:100-200

Electric Literature of C6H6N2O. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Characterization of pyridine biodegradation by two Enterobacter sp. strains immobilized on Solidago canadensis L. stem derived biochar. Author is Nie, Zimeng; Yan, Binghua; Xu, Yunhai; Awasthi, Mukesh Kumar; Yang, Haijun.

In this study, two pyridine-degrading strains namely Enterobacter cloacae complex sp. BD17 and Enterobacter sp. BD19 were isolated from the aerobic tank of a pesticide wastewater treatment plant. The mixed bacteria H4 composed of BD17 and BD19 at a ratio of 1:1 was immobilized by Solidago canadensis L. stem biochar with a dosage of 2 g·L–1. The highest pyridine removal rate of 91.70% was achieved by the immobilized H4 at an initial pyridine concentration of 200 mg·L-1, pH of 7.0, temperature of 28°C and salinity of 3.0% within 36 h. The main intermediates of pyridine degradation by BD17 were pyridine-2-carboxamide, 2-aminopropanediamide, and 2-aminoacetamide, while 2-picolinic acid, iso-Pr acetate, iso-Pr alc., and acetaldehyde were identified with BD19 by adopting GC-MS technique. Interestingly, there was a possibility of totally mineralization of pyridine and the corresponding degradation pathways of BD17 and BD19 were revealed for the first time.

There is still a lot of research devoted to this compound(SMILES：O=C(N)C1=NC=CC=C1)Electric Literature of C6H6N2O, and with the development of science, more effects of this compound(1452-77-3) can be discovered.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: D-Alanine methylamide hydrochloride( cas:61302-99-6 ) is researched.Recommanded Product: 61302-99-6.Okada, Yoshio; Tani, Shohei; Yawatari, Yuko; Yagyu, Masami published the article 《Synthesis of stereoisomeric alanine containing peptide derivatives》 about this compound( cas:61302-99-6 ) in Chemical & Pharmaceutical Bulletin. Keywords: alanine peptide stereoisomer; alanylalanine bactericide. Let’s learn more about this compound (cas:61302-99-6).

D-alanine derivatives and their stereoisomers and D-alanyl-D-alanine derivatives and their stereoisomers (R1-Ala-R2, R1-Ala-Ala-R2: R1 = PhCH2O2C, H; R2 = NHNH2, NHCH3, NHCH2CH2OH) were synthesized. All compounds obtained did not show antibacterial activity against Staphylococcus aureus, Sarcina lutea, Pseudomonas aeruginosa and Escherichia coli.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Kumata, Katsushi; Hatori, Akiko; Yamasaki, Tomoteru; Zhang, Yiding; Mori, Wakana; Fujinaga, Masayuki; Xie, Lin; Nengaki, Nobuki; Zhang, Ming-Rong published the article 《Synthesis and evaluation of 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide for PET imaging of the metabotropic glutamate receptor 2 in the rat brain》. Keywords: carbon 11 fluoromethoxyphenyl methylpyridinyl methoxypicolinamide preparation brain mGluR2 PET; In vitro autoradiography; Metabotropic glutamate receptor 2; Positron emission tomography; Radiotracer; Schizophrenia.They researched the compound: Picolinamide( cas:1452-77-3 ).Application In Synthesis of Picolinamide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

Metabotropic glutamate receptor 2 (mGluR2) has been suggested as a therapeutic target for treating schizophrenia-like symptoms arising from increased glutamate transmission in the human forebrain. However, no reliable positron emission tomog. (PET) radiotracer allowing for in vivo visualization of mGluR2 in the human brain is currently available. In this study, we synthesized 4-(2-fluoro-4-[11C]methoxyphenyl)-5-((2-methylpyridin-4-yl)methoxy)picolinamide ([11C]1) and evaluated its potential as a PET tracer for imaging mGluR2 in the rodent brain. Compound 1, a neg. allosteric modulator (NAM) of mGluR2, showed high in vitro binding affinity (IC50: 26 nM) for mGluR2 overexpressed in human cells. [11C]1 was synthesized by O-[11C]methylation of the phenol precursor 2 with [11C]methyl iodide. After the reaction, HPLC purification and formulation, [11C]1 of 7.4 ± 2.8 GBq (n = 8) was obtained from [11C]carbon dioxide of 22.5 ± 4.8 GBq (n = 8) with >99% radiochem. purity and 70 ± 32 GBq/μmol (n = 8) molar activity at the end of synthesis. In vitro autoradiog. for rat brains showed that [11C]1 binding was heterogeneously distributed in the cerebral cortex, striatum, hippocampus, and cerebellum. This pattern is consistent with the regional distribution pattern of mGluR2 in the rodent brain. The radioactivity was significantly reduced by self- or MNI-137 (a mGluR2 NAM) blocking. Small-animal PET studies indicated a low in vivo specific binding of [11C]1 in the rat brain. The brain uptake was increased in a P-glycoprotein and breast cancer resistant protein double knockout mouse, when compared to a wild-type mouse. While [11C]1 presented limited potential as an in vivo PET tracer for mGluR2, we suggested that it can be used as a lead compound for developing new radiotracers with improved in vivo brain properties.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: Picolinamide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Phase Transfer Ceria-Supported Nanocatalyst for Nitrile Hydration Reaction. Author is Gupta, Nikitra N.; Punekar, Amrin S.; Raj, Karthik Raja E. K.; Ghodekar, Medha M.; Patil, Vipul S.; Gopinath, Chinnakonda S.; Raja, Thirumalaiswamy.

The present study elaborates the catalytic effect of rare-earth metal oxides (Sm2O3 and La2O3) over ceria as a support phase transfer catalyst. The synthesized catalysts have been subjected to different characterization techniques, such as field-emission SEM, high-resolution transmission electron microscopy, powder X-ray diffraction, N2 adsorption-desorption (BET surface anal.), temperature-programmed desorption study (NH3/CO2-TPD), Fourier transform IR, Raman anal., and XPS to get better insights into the catalytic activity of the catalysts for hydration of nitrile.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1452-77-3, is researched, Molecular C6H6N2O, about Lamotrigine: Design and synthesis of new multicomponent solid forms, the main research direction is lamotrigine multicomponent solid forms; Co-crystals and salts; Diflunisal; Lamotrigine; Pyridinecarboxamides; Stability assay; Xanthines.Recommanded Product: 1452-77-3.

In this work, a crystal engineering and thermodn. based approach has been used aiming at contributing to a deeper knowledge of lamotrigine multicomponent solid forms. Two types of co-mols. have been chosen that can give rise to co-crystals with lamotrigine through different supramol. heterosynthons: the xanthines, theophylline and caffeine, and the three isomeric pyridinecarboxamides. Association with diflunisal, which may result in a salt, was also investigated. Mechanochem., differential scanning calorimetry, thermogravimetry, X-ray powder and single crystal diffraction, IR spectroscopy were the methods used. For all the systems, exploratory neat mechanochem. experiments, carried out on lamotrigine + co-mol. binary mixtures of different compositions, were not successful in promoting association From differential scanning calorimetry data and the binary solid-liquid phase diagrams, co-crystals/salts were identified as well as their resp. stoichiometry, and a methodol. of synthesis was established. For pyridinecarboxamides, mol. recognition is dependent on the position of the amide group in the pyridine ring: co-crystallization did not occur with picolinamide co-former. Both xanthines form co-crystals with lamotrigine, (1:1) with theophylline and (2:1) lamotrigine:caffeine. Addnl., the crystalline structure of a lamotrigine:theophylline 1:1 monohydrate was solved. The (1:1) lamotrigine:theophylline co-crystal converts to this monohydrate in accelerated stability tests. A (1:1) lamotrigine:diflunisal salt was identified, which proved to be stable in accelerated stability assays.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Reference of Picolinamide. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Half-sandwich ruthenium(II) complexes containing O, N bidentate azo ligands: Synthesis, structure and their catalytic activity towards one-pot conversion of aldehydes to primary amides and transfer hydrogenation of ketones. Author is Nandhini, Raja; Venkatachalam, Galmari.

Ruthenium(II) complexes of the general formula [Ru(η6-p-cymene)(Cl)(L1-5)] (L = O, N-donors of biphenylazo derivatives), were synthesized via reacting 2-(biphenylazo)phenols and 1-(biphenylazo)naphthol ligands with [{η6-(p-cymene)RuCl}2(μ-Cl)2]. The synthesized complexes could act as an efficient, reusable homogeneous catalyst for transformation of aldehydes to the corresponding primary amides ArC(O)NH2 [Ar = Ph, 4-MeC6H4, 2-pyridyl, etc.] in the presence of NH2OH·HCl, thus resulted an expansion of Beckmann rearrangement. They also effectively catalyzed the transfer hydrogenation reaction of various ketones with KOH in presence of 2-propanol to afford RCHOHR1 [R = Et, n-Pr, Ph, 4-MeOC6H4; R1 = Me, Ph; R1R2 = (CH2)5, (CH2)6].

If you want to learn more about this compound(Picolinamide)Reference of Picolinamide, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1452-77-3).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Yan, Xinlong; Dong, Qing; Li, Ying; Meng, Lizhen; Hao, Zhiqiang; Han, Zhangang; Lu, Guo-Liang; Lin, Jin published the article 《Aerobic oxidation of primary benzylic amines to amides and nitriles catalyzed by ruthenium carbonyl clusters carrying N,O-bidentate ligands》. Keywords: trinuclear ruthenium carbonyl catalyst preparation; nitrile preparation; amide preparation; benzylic amine aerobic oxidation.They researched the compound: Picolinamide( cas:1452-77-3 ).Name: Picolinamide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1452-77-3) here.

Four trinuclear ruthenium carbonyl clusters were synthesized from the reactions of Ru3(CO)12 with the corresponding N,O-bidentate ligands (two pyridyl alcs. and two Schiff bases) resp. in a ratio of 1 : 2. Three new complexes were fully characterized by elemental anal., FT-IR, NMR and X-ray crystallog. The catalytic activity of these ruthenium complexes for the aerobic oxidation of primary benzylic amines to amides and nitriles in the presence of t-BuOK was investigated.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Okada, Yoshio; Tani, Shohei; Yawatari, Yuko; Yagyu, Masami researched the compound: D-Alanine methylamide hydrochloride( cas:61302-99-6 ).Recommanded Product: 61302-99-6.They published the article 《Synthesis of stereoisomeric alanine containing peptide derivatives》 about this compound( cas:61302-99-6 ) in Chemical & Pharmaceutical Bulletin. Keywords: alanine peptide stereoisomer; alanylalanine bactericide. We’ll tell you more about this compound (cas:61302-99-6).

D-alanine derivatives and their stereoisomers and D-alanyl-D-alanine derivatives and their stereoisomers (R1-Ala-R2, R1-Ala-Ala-R2: R1 = PhCH2O2C, H; R2 = NHNH2, NHCH3, NHCH2CH2OH) were synthesized. All compounds obtained did not show antibacterial activity against Staphylococcus aureus, Sarcina lutea, Pseudomonas aeruginosa and Escherichia coli.

If you want to learn more about this compound(D-Alanine methylamide hydrochloride)Recommanded Product: 61302-99-6, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(61302-99-6).

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C6H6N2O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Picolinamide, is researched, Molecular C6H6N2O, CAS is 1452-77-3, about Aqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst. Author is Ounkham, Whalmany L.; Weeden, Jason A.; Frost, Brian J..

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the Taiwan Institute of Chemical Engineers called Conceptual design, environmental, and economic evaluation of direct copolymerization process of carbon dioxide and 1,4-butanediol, Author is Yu, Yueh-Cheng; Wang, Ting-Ya; Chang, Li-Hsuan; Wu, Pei-Jhen; Yu, Bor-Yih; Yu, Wen-Yueh, which mentions a compound: 1452-77-3, SMILESS is O=C(N)C1=NC=CC=C1, Molecular C6H6N2O, Product Details of 1452-77-3.

The routes to convert CO2 into environmentally benign materials have attracted wide attentions. In this work, an emerging process to produce poly(butylene carbonate) (or PBC) from direct copolymerization of carbon dioxide and 1,4-butanediol is firstly simulated with analyses on the CO2 emission ratio (CO2-e, in kg-CO2/kg-PBC) and yearly unit manufacturing cost of product (YUMC, in USD/kg). In order to address the issues associated with large amount of solvents used in the lab scale, two proposed scenarios including the reduction of solvent amount, and heat integration by vapor recompression cycle (VRC) were simulated. It is found that CO2-e is reduced by 82.0% (from 30.06 to 5.42) when the solvent amount is reduced to 10%, and another 19.9% reduction in CO2-e (to 4.34) when applying the VRC. YUMCs are reduced by ca. 68% for both proposed scenarios (from 5.62 to ca. 1.8). The findings reported in this study may prove informative for developing CO2 conversion technologies from lab scale to industrial scale.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem