Tag: M.W:100-200

Chemical Research Letters, May 2021. Computed Properties of C9H10ClN, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.33537-99-4, Name is 6-Chloro-1,2,3,4-tetrahydroisoquinoline, molecular formula is C9H10ClN. In a Article，once mentioned of 33537-99-4

The title heterocycles (3) have been obtained by a two-step synthesis; namely an initial intramolecular sulphonamidomethylation of N-aralkylsulphonamides (1) in acid media followed by desulphonylation of compounds (2) under moderate conditions, either by reduction or acid hydrolysis.Generally both steps gave good or high yields of compounds (3) variously substituted in the aromatic ring and with a six-, seven-, or eight-membered heterocyclic ring.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New Advances in Chemical Research, May 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. Application of 1745-07-9, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1745-07-9, name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline. In an article，Which mentioned a new discovery about 1745-07-9

Mixture analysis can provide information on individual components if the sample is first subjected to chromatographic separation. Two critical capabilities, soft ionization and the ability to mass-select and then dissociate ions of a particular m/z, coalesced in 1975, allowing direct analysis of complex mixtures by mass spectrometry. Chemical ionization was used as the soft ionization method and mass-analysis used the ion kinetic energy spectrometer (MIKES). Soft molecular ionization produces a set of ions that are structural surrogates of the neutral molecules; they can be mass-selected and allowed to spontaneously dissociate (i.e. as metastable ions) or fragmented upon energy transfer e.g. in the course of collision-induced dissociation (CID). The second stage of mass analysis provides information about the atomic connectivity in the precursor ion and by implication in the original molecule. This review focuses on the development of complex mixture analysis by mass spectrometry and allied topics. Discussion of the activation techniques associated with (collision-induced dissociation, surface-induced dissociation and metastable ion dissociation) emphasizes the importance of energy transfer phenomena and the internal energies distributions of ions to explain the observed mass spectra. The translational to internal energy transfer in collisions is readily accessed in the MIKES where the second stage mass analyzer is a kinetic energy/charge analyzer. Collisions in the keV range can also be used to change ion the charge state via the processes of charge exchange, electron stripping, or charge inversion. New ionization sources for analysis of non-volatile compounds that were introduced during the time period (1975-1990) of this review included secondary ion mass spectrometry, plasma desorption and field ionization and they are briefly discussed. Several types of scans were developed to rapidly access information of the individual components, including chemically specific scans (e.g. neutral loss scans of mass 30 for nitro compounds).

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. An article , which mentions Computed Properties of C11H15NO2, molecular formula is C11H15NO2. The compound – 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline played an important role in people’s production and life., Computed Properties of C11H15NO2

An efficient visible-light-induced alpha-oxidation of N-substituted tetrahydroisoquinolines to dihydroisoquinolones has been developed using eosin Y as an organo-photocatalyst and oxygen as a green oxidant. The reactions were carried out under mild reaction conditions; the desired dihydroisoquinolones were obtained in up to 96% yield at room temperature under oxygen atmosphere. This transformation provides a convenient route to dihydroisoquinolones with a wide range of substrates. (Figure presented.).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New research progress on 42923-79-5 in 2021. Product Details of 42923-79-5, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 42923-79-5, molcular formula is C9H10N2O2, introducing its new discovery.

Conformationally constrained analogue synthesis was undertaken to aid in pharmacophore mapping and 3D-QSAR analysis of nitrobenzylmercaptopurine riboside (NBMPR) congeners as equilibriative nucleoside transporter 1 (ENT1) inhibitors. In our previous study [J. Med. Chem. 2003, 46, 831-837], novel regioisomeric nitro-1,2,3,4-tetrahydroisoquinoline conformationally constrained analogues of NBMPR were synthesized and evaluated as ENT1 ligands. 7-NO2-1,2,3,4-Tetrahydroisoquino-2-yl purine riboside was identified as the analogue with the nitro group in the best orientation at the NBMPR binding site of ENT1. In the present study, further conformational constraining was introduced by synthesizing 5?-O,8-cyclo derivatives. The flow cytometrically determined binding affinities indicated that the additional 5?-O,8-cyclo constraining was unfavorable for binding to the ENT1 transporter. The structure-activity relationship (SAR) acquired was applied to pharmacophore mapping using the PHASE program. The best pharmacophore hypothesis obtained embodied an anti-conformation with three hydrogen-bond acceptors, one hydrophobic center, and two aromatic rings involving the 3?-OH, 4?-oxygen, the NO2 group, the benzyl phenyl and the imidazole and pyrimidine portions of the purine ring, respectively. A PHASE 3D-QSAR model derived with this pharmacophore yielded an r2 of 0.916 for four (4) PLS components, and an excellent external test set predictive r2 of 0.78 for 39 compounds. This pharmacophore was used for molecular alignment in a comparative molecular field analysis (CoMFA) 3D-QSAR study that also afforded a predictive model with external test set validation predictive r2 of 0.73. Thus, although limited, this study suggests that the bioactive conformation for NBMPR at the ENT1 transporter could be anti. The study has also suggested an ENT1 inhibitory pharmacophore, and established a predictive CoMFA 3D-QSAR model that might be useful for novel ENT1 inhibitor discovery and optimization.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1745-07-9, name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery. Synthetic Route of 1745-07-9

Starting from lead compound 1 (EC50 = 1.64 muM), its non-basic nucleus has been conformationally restricted by 4-biphenyl and 2-naphthyl moieties. In each series we investigated if the presence of H-bond donor or acceptor substituents, the basicity and the lipophilicity (c log P) were correlated with the P-gp inhibiting activity of tested compounds. In the biphenyl series, derivative 4d displayed the best results (EC50 = 0.05 muM). The corresponding amide 3d was found less active (EC50 = 3.5 muM) ascertaining the importance of basicity in this series whilst the presence of hydroxy or methoxy substituents seems to be negligible. In the naphthyl series, both the basicity and the presence of H-bond donor or acceptor groups seem to be negligible. Moreover, the lipophilicity did not influence the P-gp inhibition activity of each series. Specific biological assays have been carried out to establish the P-gp interacting mechanism of tested compounds discriminating between substrates and inhibitors. Moreover, compound 4d displayed a potent P-gp inhibition activity with good selectivity towards BCRP pump.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 57196-62-0, name is 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, introducing its new discovery. Recommanded Product: 6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride

Two three-dimensional metal-organic frameworks, [Cd3K(L 1)6(H2O)3](OH)(DMF)4 (1) (HL1 = 3-pyrid-4-ylbenzoic acid) and [Cd(L2) 2](DMF)(H2O)0.25 (2) (HL2 = 4-pyrid-4-ylbenzoic acid), have been synthesized by using two ligands with different configuration and characterized by X-Ray diffraction and other techniques. Compound 1 shows a nanosize channel which is constructed by interlocked six-fold one-dimensional helical chains with the asymmetrical ligand HL1. Compared with compound 1, compound 2 shows a larger size channel with the symmetrical ligand HL2 in a single set of diamond cage. Nevertheless, the whole structure with the 4-fold interpenetrated diamondoid network leads to the absence of void space. The two compounds exhibit fascinating luminescence because of the interaction between Cd ions and organic ligands. The Royal Society of Chemistry 2012.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New research progress on 82771-60-6 in 2021. name: 7-Chloro-1,2,3,4-tetrahydroisoquinoline, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 82771-60-6, molcular formula is C9H10ClN, introducing its new discovery.

Substituted N-tert-butoxycarbonyl (Boc)-1,2,3,4-tetrahydroisoquinolines were prepared and treated with n-butyllithium in THF at -50 C to test the scope of the metallation and electrophilic quench. The lithiation was optimised by using in situ ReactIR spectroscopy and the rate of rotation of the carbamate was determined. The 1-lithiated intermediates could be trapped with a variety of electrophiles to give good yields of 1-substituted tetrahydroisoquinoline products. Treatment with acid or reduction with LiAlH4 allows conversion to the N-H or N-Me compound. The chemistry was applied to the efficient total syntheses of the alkaloids (±)-crispine A and (±)-dysoxyline.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Research speed reading in 2021. Recommanded Product: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2. In a Patent，once mentioned of 1745-07-9

The invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, and more particularly to some tetrahydroisoquinoline substituted sulfonamide compounds of the formula I: to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which 5-HT is involved, such as CNS disorders.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

New Advances in Chemical Research in 2021. In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 1745-07-9, name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, introducing its new discovery. 1745-07-9

Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Research speed reading in 2021. Recommanded Product: 1745-07-9, Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 1745-07-9, Name is 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline, molecular formula is C11H15NO2. In a Article，once mentioned of 1745-07-9

ZnBr2 in dichloromethane is a convenient reagent for mild and selective removal of the tert-butoxycarbonyl group from secondary amines.

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Reference：
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem