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Compositions comprising a lipid lowering agent selected from cholesterol biosynthesis inhibitors, bile acid sequestrants, fibrates, cholesterol absorption inhibitors, and niacin; and an inhibitor of microsomal triglyceride transfer protein for treating atherosclerosis, obesity and related diseases.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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A cross-dehydrogenative coupling (CDC) reaction between tertiary amines and nitroalkanes has been realized under an oxygen atmosphere in water simply by using graphene-supported RuO2 as the catalyst, which was made from water-soluble graphene with sulfonic groups and RuCl3·nH 2O to form RuO2·nH2O nanocomposites in situ. In contrast to RuCl3·nH2O and RuO 2·nH2O, the graphene-supported RuO2 nanoparticles exhibited higher activity and stability for the aerobic CDC reaction in water.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Use, The present invention relates to a pharmaceutical composition comprising a compound of Formula I or a pharmaceutically acceptable salt, solvate, ester, optical isomer or prodrug, of a compound of Formula, and a use, thereof as I mutant high-selectivity Bruton’s tyrosine kinase inhibitor for the preparation of a medicament for preventing or treating an autoimmune disease BTK(C481S), autoimmune disease or cancer. (by machine translation)

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Tetrahydroisoquinoline – Wikipedia,
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The present invention relates to a 2,9-dimethyl -4,7-diphenyl -1,10-O-phenanthrene carborane double-phenyl a phosphine price copper complexes in the visible light catalytic 2-methyl quinoline compounds with tetrahydroisoquinoline compound dehydrogenation method of coupling reaction. The preparation method of this invention is: the photocatalyst 2,9-dimethyl -4,7-diphenyl -1,10-O-phenanthrene carborane double-phenyl a phosphine price copper complex, the corresponding 2-methyl quinoline, tetrahydroisoquinoline and inter-methyl benzoic acid according to 0.015: 2:1:3 molar ratio of mixing, adding solvent acetonitrile and methanol, acetonitrile and methanol in accordance with the 1:1 volume ratio of mixing, the reaction system is filled with oxygen, mercury distance of 2 cm is at 3.5w white light of the lamp strip led, in 35 hours later, the solvent out of the reaction system, through the silica gel column chromatography separation, to obtain the corresponding product. The beneficial effect of this method for the use of visible photocatalytic reaction, environmental protection and low carbon. (by machine translation)

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Iminium ions generated in situ via copper(I) bromide catalyzed oxidation of N-aryl amines readily undergo [4 + 2] cycloadditions with a range of dienophiles. This method involves the functionalization of both a C(sp 3)-H and a C(sp2)-H bond and enables the rapid construction of polycyclic amines under relatively mild conditions.

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Heteroaromatic bases containing nitrogen atoms were easily alkylated with carboxylic acids in the presence of benzene and pentafluorobenzene via radical pathways.Similarly, the alkylation onto heteroaromatic bases was carried out with oxalic acid monoalkyl esters, which were prepared from alcohols and oxalyl dichloride, in the presence of the same trivalent iodine compounds.Moreover, this system was applied to the synthesis of C-nucleosides with the carboxylic acids bearing a sugar moiety.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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A novel method for the synthesis of cyanomethylated tetrahydroisoquinolines has been developed with mild reaction conditions, good yields and a broad substrate scope. Acetonitrile, a common solvent, is for the first time used as a pronucleophile for this type of two sp3C?H bonds cross-dehydrogenative coupling (CDC) reaction. A new oxidative system (CuCl2/TEMPO/Cs2CO3) has been established by our group, in which the mild TEMPO reagent was found to be a highly efficient oxidant. (Figure presented.).

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A photoredox-catalyzed umpolung strategy for coupling reactions between aldehydes, ketones, imines, and N-arylamines is reported. These reactions proceed by a Br°nsted acid-activated proton-coupled electron transfer pathway, and the protocol was used to synthesize a broad scope of 1,2-amino alcohols and vicinal diamines, both of which are common motifs in biologically active natural products, pharmaceutically active molecules, and ligands.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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The invention mainly relates to a synthesis method of 5 a 6 – compound represented 5 2 – 1 – alpha by the following formula (I) in the formula (I), and the derivatives of the isoquinoline and the isoquinoline are represented by the following formula (I). To the invention, in the copper catalysis and air atmosphere, the technical proposal of 1 the 2 oxime 3 ester 4 – compound, the one-pot compound represented by 2 – the 5 invention 6 – the 5 tetrahydroisoquinoline 1 – alpha compound and the derivatives thereof is produced by one pot. In the method, copper metal catalysis is used in the method, and a new path is provided for the synthesis of the 2 – isoquinoline 5 compounds 6 – with the 5 substitution 1 – alpha degree of the substituent (s) of the compound (s), and the isoquinoline compounds represented by the above-mentioned scheme (I). The method has the characteristics of simple reaction system, mild reaction conditions, less reaction equipment, simple experiment operation, moderate yield and the like. (by machine translation)

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Aryl radicals cyclize to an imino functional group in a competition involving 6-endo closure to C and 5-exo closure to N. there is a large 6-endo preference forming tetrahydroisoquinolinyl radicals with k(6-endo) (80C) > 108 s-1.

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Tetrahydroisoquinoline – Wikipedia,
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