Some scientific research about 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

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One-pot transition-metal-free synthesis of weinreb amides directly from carboxylic acids

Weinreb amides were prepared directly from carboxylic acids, N,O-dimethylhydroxylamine, and phosphorus trichloride in one pot at 60 C in toluene in high yields, thus avoiding the separation of the moisture and air sensitive intermediate P[NMe(OMe)]3 in advance. Sterically hindered carboxylic acids also give the corresponding Weinreb amides in excellent yields. Various functional groups are tolerated on the carboxylic acid. The method, which is a simple process and gives high yields, is suitable for large-scale production. Georg Thieme Verlag KG Stuttgart ¡¤ New York.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

A new application about 166591-85-1

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Decarboxylative alkynylation and cyanation of carboxylic acids using photoredox catalysis and hypervalent iodine reagents

Alkynes and nitriles are important functional groups that serve as versatile building blocks in organic synthesis and find applications in material and medicinal sciences. A convenient and straightforward access to both classes of compounds under mild conditions is, therefore, highly desirable. Herein, we disclose the decarb-oxylative alkynylation and cyanation of broadly available carboxylic acids using photoredox catalysis and hyper-valent iodine reagents. Choices of both catalysts and reagents were crucial. Computational and experimental studies revealed two different possible mechanisms that are dictated by the oxidation potential of the reagents: radical for alkynylation, ionic for cyanation.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

A new application about 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

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WNT PATHWAY ANTAGONISTS

The present invention relates to known and novel compounds of formula (I) as herein described and pharmaceutical compositions thereof. The compounds of formula (I) have inhibitory effect on the Wnt pathway and are therefore useful in the preparation of a medicament, in particular for the treatment of cancer

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Discovery of 1-Phenyl-1,2,3,4-tetrahydroisoquinoline

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Ring-opening Reactions of N-Aryl-1,2,3,4-tetrahydroisoquinoline Derivatives

The reaction of N-nitroaryl-1,2,3,4-tetrahydroisoquinolines 1a-e, 1g and 1j with N-bromosuccinimide (NBS) afforded aldehydes 3a-e, 3h and 3j respectively.N-(4-Nitrophenyl)-1-phenyl-1,2,3,4-tetrahydroisoquinoline 1n gave ketone 3n together with brominated product 3o when treated with NBS.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Awesome and Easy Science Experiments about 170097-67-3

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AMINOPYRAZINE COMPOUNDS USEFUL AS INHIBITORS OF TRA KINASE

The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I): wherein the variables are as defined herein.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

More research is needed about (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

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118864-75-8, Name is (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline, belongs to tetrahydroisoquinoline compound, is a common compound. COA of Formula: C15H15NIn an article, once mentioned the new application about 118864-75-8.

thorley that new process for the preparation of intermediates (by machine translation)

The invention belongs to the field of medicine, in particular relates to a new process for the preparation of intermediates thorley that. The 2-halo benzophenoneoxime protection of the carbonyl group, n-butyl aldehyde after the lithium pulls out the bromine on, then with nitro methane condensation, catalytic hydrogenation reduction postacidification, then loop, passes through the reduction, chiral resolution alkaline hydrolysis after the new intermediate compounds by thorley I; the new intermediate thorley that the structural formula is: The invention utilizes the simple and easily obtained starting material, the production cost is reduced. This process route is advanced, mild reaction conditions, the reaction yield is high, little three waste, no expensive and toxic reagent, reaction solvent distillation can be applied mechanically, easy commercial production, has great social and economical benefits of environmental protection. (by machine translation)

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Awesome and Easy Science Experiments about 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

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PROCESS FOR THE PREPARATION OF ALFUZOSIN

The present invention relates to an improved process for the preparation of N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydrofuran-2-carboxamide of Formula (I).

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

A new application about 3340-78-1

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alpha-Cyanation of Aromatic Tertiary Amines using Ferricyanide as a Non-Toxic Cyanide Source

The reaction of aromatic tertiary amines with potassium ferricyanide directly provides the useful alpha-amino nitriles. The inexpensive iron complex functions both as an oxidant and as a cyanide source. The presence of molecular oxygen speeds up the reaction which can be performed in aqueous tert-butanol or even in ethanol-based mixtures like Tequila. While amine cyanations usually employ highly toxic cyanide sources, potassium ferricyanide is even less toxic than table salt. No expensive metal complexes are required as catalysts and the co-product of the cyanation, Prussian blue, has no known toxicity and is rather used as an antidote.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Extended knowledge of 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

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Composition containing heterocyclic compounds and a method of lubricating an internal combustion engine

The present invention relates to a lubricating composition containing (a) an oil of lubricating viscosity; and (b) a compound selected from the group consisting of: (i) an ester-containing heterocycle; (ii) an amide-containing heterocycle; and (iii) a pyrimidine, wherein the ester-containing heterocycle and the amide-containing heterocycle have a hydrocarbyl group containing 6 to 40 carbon atoms. The invention further provides for a method of supplying an internal combustion engine with the lubricating composition.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The Absolute Best Science Experiment for 2-Phenyl-1,2,3,4-tetrahydroisoquinoline

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Light-mediated heterogeneous cross dehydrogenative coupling reactions: Metal oxides as efficient, recyclable, photoredox catalysts in C-C bond-forming reactions

Let there be light: A heterogeneous photocatalytic system based on easily recyclable TiO2 or ZnO allows cross dehydrogenative coupling reactions of tertiary amines. The newly developed protocols have successfully been applied to various C-C and C-P bond-forming reactions to provide nitro amines as well as amino ketones, nitriles and phosphonates. Copyright

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem