Discovery of (S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

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Bifunctional Squaramide Organocatalysts for the Asymmetric Addition of Formaldehyde tert-Butylhydrazone to Simple Aldehydes

The nucleophilic addition of formaldehyde tert-butylhydrazone to simple aldehydes (a formal hetero-carbonyl?ene reaction) can be performed with good reactivity and excellent enantioselectivity by virtue of the dual hydrogen-bonding activation exerted by amide?squaramide organocatalysts. The resulting hydroxydiazenes (azo alcohols) were isolated in high yields as enantiomerically enriched azoxy compounds after a regioselective azo-to-azoxy transformation. Subsequent derivatization provides an entry to relevant amino alcohols, oxazolidinones, and derivatives thereof.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Can You Really Do Chemisty Experiments About 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

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6-HETEROCYCLYL-4-MORPHOLIN-4-YLPYRIDINE-2-ONE COMPOUNDS USEFUL FOR THE TREATMENT OF CANCER AND DIABETES

The invention provides novel 6-heterocyclyl-4-morpholin-4-yl-pyridine-2-one compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for using such compounds in treatment of diseases including cancer, diabetes, inflammatory disease, neurodegenerative disorders, cardiovascular disorders and viral infections; wherein R1, R2, R3 and A are as defined in the specification.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Mechanochemical Oxidative Mannich Reaction: Evaluation of Chemical and Mechanical Parameters for the Mild and Chemoselective Coupling of N-tert-butoxycarbonyltetrahydroquinolines and Ketones

A mechanochemical oxidative Mannich reaction of N-tert-butoxycarbonyl (Boc) tetrahydroquinolines and ketones was successfully developed under solvent-free ball-milling conditions. The reaction afforded the desired coupling products in satisfactory yields under mild and tractable oxidative conditions. Side reactions such as deprotection of the Boc group were prevented by carefully adjusting the milling parameters, including milling frequency, time, milling-ball filling degree, milling-ball size, and grinding auxiliary. Further examination of the scope indicated that the reaction system could also be applied to the N-benzyloxycarbonyl and N-aryl substrates to afford the corresponding products in moderate to good yields.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Extracurricular laboratory:new discovery of 7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride

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Synthesis and antimalarial activity of 7-benzylamino-1-isoquinolinamines

(Chemical Equation Presented) Computer modelling suggests that 7-benzylamino-1-isoquinolinamines should mediate antimalarial effects by a mechanism distinct from that employed by existing antimalarial drugs. A series of these compounds was prepared in seven synthetic steps, via reductive amination of 1,7-isoquinolinediamine. In vitro efficacy testing of the novel compounds against Plasmodium falciparum revealed them to be potent antimalarial agents.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Top Picks: new discover of 17680-55-6

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2- Pyridine substituted urea structure small molecule compound as well as synthesis and application thereof (by machine translation)

The invention relates to 2 -pyridyl substituted urea structure small molecule compounds and synthesis and application. specifically, and discloses application (I) of the compound, as shown in formula, as an enantiomer, diastereomer, racemate or a mixture, or a pharmaceutically acceptable salt ASK1 hydrate and a solvate thereof in preparing, small molecule inhibitor/or prevention and ASK1 or treatment of, related diseases, in particular liver disease, pulmonary disease, cardiovascular disease. (by machine translation)

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Pd-catalyzed synthesis of aryl amines via oxidative aromatization of cyclic ketones and amines with molecular oxygen

Pd-catalyzed intermolecular aerobic dehydrogenative aromatizations have been developed for the arylation of amines with nonaromatic ketones. Under optimized reaction conditions, primary and secondary amines are selectively arylated in good yields with cyclohexanones and 2-cyclohexen-1-ones in the presence of a Pd-catalyst under an atmosphere of molecular oxygen.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Can You Really Do Chemisty Experiments About 7-Bromo-1,2,3,4-tetrahydroisoquinoline

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Visible light catalyzed Mannich reaction between: Tert -amines and silyl diazoenolates

The present work documents the alpha-C-H functionalization of tertiary amines via the visible light catalyzed Mannich reaction with silyl diazoenolates. The reaction takes place at room temperature with an organic dye, Rose Bengal, as a photocatalyst and oxygen as the oxidant. The resulting multifunctional products bearing an alpha-diazo-beta-keto group undergo Rh-carbenoid mediated cyclization, affording stable ammonium ylides in high yields.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Final Thoughts on Chemistry for 1-Phenyl-1,2,3,4-tetrahydroisoquinoline

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A succinic acid Solley that new raw materials of synthesizing process (by machine translation)

The invention discloses a succinic acid thorley that new raw materials of synthesizing process, respectively in order to 2 – phenethylamine and 3 – synthesizing hydrochloride as the starting material synthetic fragment A, fragment B, the occurrence of the condensation reaction produced Solley that new, by succinic acid and get thorley that new, characterized in that using straight chain paraffins and water is used as the reaction solvent, alkali metal hydroxide or carbonate, hydrogencarbonate for capture, phenethylamine takes acylation reaction with benzoyl chloride is not soluble in the reaction solvent of solid precipitation fragment A intermediate 1, after treatment directly during the filtering; fragment A isomer, using dimethyl sulfoxide as solvent, alkali metal hydroxide catalytic racemic, the by-product isomer can be recycled; fragment of B 2nd step treatment after the reaction, the conventional vacuum distillation method to obtain a high purity, high yield of 3 – acetoxy quinine acetic acid salt, the invention provides a high yield, is suitable for industrial mass production, economic and environmental protection new synthesis process. (by machine translation)

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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Based on benzothiazole unit a covalent organic framework material synthetic method (by machine translation)

The invention discloses a covalently bound based on benzothiazole unit method for synthesizing organic framework material, comprising the following steps: in an organic solvent or in ionic liquid, 2, 4, 6-trihydroxy are three phenyltheophylline formaldehyde and 2,6-diaminobenzene and b thiazole reaction to obtain the organic framework material of covalency. The method to obtain covalent organic framework material has relatively large specific surface area and pore structure of the rules, it is a kind of good photocatalyst material, can be used for the photocatalytic N-aryl tetrahydroisoquinoline cross-dehydrogenation coupling reaction, has good stability and excellent catalytic effect. (by machine translation)

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

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PROCESSES FOR THE PREPARATION OF SOLIFENACIN OR A SALT THEREOF

The present invention describes recovery and racemization of (1R)-Phenyl- 1,2,3,4-tetrahydroisoquinoline of compound of formula (III) to obtain racemic 1- phenyl-1, 2,3,4-tetrahydroisoquinoline of compound of formula (I) and its further resolution to get ( IS)-1-phenyl-1, 2, 3, 4-tetrahydroisoquinoline (intermediate B) in high chemical and chiral purity, which is the key intermediate for the preparation of (3R)-azabicyclo[2.2.2]oct-3-yl (1S)-1-phenyl-3,4-dihydroisoquinoline-2-(1H)- carboxylate.

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Reference£º
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem