Tag: M.W:200-300

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 693-67-4, is researched, Molecular C11H23Br, about Liquid crystal and photoluminescent properties of a series of symmetrical 1,2-bis(4-alkoxybenzylidene)hydrazines bearing long-tails of hydrocarbon chain, the main research direction is bis alkoxy benzylidene hydrazine preparation liquid crystal fluorescence.Synthetic Route of C11H23Br.

In this work, 1,2-bis[4-(n-alkoxy)benzylidene]hydrazine (n-alkoxy: O(CH2)nH, n = 11-18 or 20), a sym. series of azines (linear compounds with rod-like shape structure), were synthesized using a very simple two-step procedure as a part of our continuing effort in evaluating hydrophobic 1,2-disubstituted hydrazine compounds as photoluminescent liquid crystalline materials. The first step of the synthesis involved the alkylation of the OH group of 4-hydroxybenzaldehyde in basic medium using the Williamson method to obtain 4-alkoxybenzaldehydes. While the second step included the condensation reaction of hydrazine hydrate and appropriately 4-alkoxybenzaldehydes compounds (mole ratio 1:2, resp.) in acidic medium under ambient conditions. The prepared compounds were characterised and their structures elucidated depending upon IR (IR), UV-visible (UV-Vis), NMR (1HNMR, 13CNMR, DEPT NMR, 2D 1H-1H-COSY and 2D 1H-13C- HSQC) and elemental anal. (CHN). Liquid crystalline behavior and photoluminescent properties were studied using polarised light optical microscopy (POM), fluorescence emissions (FE), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD) techniques. The studies showed that all of these compounds were enantiotropic liquid crystalline materials exhibiting smectic (SmA and SmC) and nematic (droplet and thread) mesophases . The study also displayed that all of the prepared compounds were photoluminescent in the crystalline and liquid crystal states.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Colloid and Interface Science called One-step zwitterionization and quaternization of thick PDMAEMA layer grafted through subsurface-initiated ATRP for robust antibiofouling and antibacterial coating on PDMS, Author is Yu, Xin; Yang, Yang; Yang, Wufang; Wang, Xungai; Liu, Xin; Zhou, Feng; Zhao, Yan, which mentions a compound: 693-67-4, SMILESS is CCCCCCCCCCCBr, Molecular C11H23Br, Reference of 1-Bromoundecane.

In this work, we demonstrate the grafting of thick poly((2-dimethylamino) Et methacrylate) (PDMAEMA) layer on PDMS via subsurface-initiated atom transfer radical polymerization (SSI-ATRP). The self-migration of DMAEMA monomers into the subsurface of PDMS is proven to be the dominant factor for the success of SSI-ATRP. The as-prepared thick microscale graft layer on PDMS shows much better abrasion resistance than nanoscale graft layer obtained by conventional surface-initiated atom transfer radical polymerization (SI-ATRP) under identical condition. Taking advantage of the tertiary amines of PDMAEMA, the simultaneous zwitterionization and quaternization of the PDMAEMA thick layer is realized through a facile one-step process. The effect of zwitterionization and quaternization degree on the antibiofouling and antibacterial properties is investigated. The results show that a relatively high zwitterionization degree (75 mol%) and a low quaternization degree (25 mol%) exhibit a good well-balanced effect on both fouling repellence and bactericidal activity. This work may lead to the development of robust bifunctional antibiofouling and antibacterial surfaces via SSI-ATRP strategy.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Safety of 1-Bromoundecane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-Bromoundecane, is researched, Molecular C11H23Br, CAS is 693-67-4, about Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers. Author is Zhang, Dapeng; Atochina-Vasserman, Elena N.; Maurya, Devendra S.; Liu, Matthew; Xiao, Qi; Lu, Juncheng; Lauri, George; Ona, Nathan; Reagan, Erin K.; Ni, Houping; Weissman, Drew; Percec, Virgil.

Targeted and efficient delivery of nucleic acids with viral and synthetic vectors is the key step of genetic nanomedicine. The four-component lipid nanoparticle synthetic delivery systems consisting of ionizable lipids, phospholipids, cholesterol, and a PEG-conjugated lipid, assembled by microfluidic or T-tube technol., have been extraordinarily successful for delivery of mRNA to provide Covid-19 vaccines. Recently, we reported a one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer (IAJD) synthetic delivery system for mRNA relying on amphiphilic Janus dendrimers and glycodendrimers developed in our laboratory Amphiphilic Janus dendrimers consist of functional hydrophilic dendrons conjugated to hydrophobic dendrons. Co-assembly of IAJDs with mRNA into dendrimersome nanoparticles (DNPs) occurs by simple injection in acetate buffer, rather than by microfluidic devices, and provides a very efficient system for delivery of mRNA to lung. Here we report the replacement of most of the hydrophilic fragment of the dendron from IAJDs, maintaining only its ionizable amine, while changing its interconnecting group to the hydrophobic dendron from amide to ester. The resulting IAJDs demonstrated that protonated ionizable amines play dual roles of hydrophilic fragment and binding ligand for mRNA, changing delivery from lung to spleen and/or liver. Replacing the interconnecting ester with the amide switched the delivery back to lung. Delivery predominantly to liver is favored by pairs of odd and even alkyl groups in the hydrophobic dendron. This simple structural change transformed the targeted delivery of mRNA mediated with IAJDs, from lung to liver and spleen, and expands the utility of DNPs from therapeutics to vaccines.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2241400-93-9, is researched, Molecular C7H7BrN2O2, about Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase, the main research direction is NFkappaB kinase inhibitor preparation immunomodulator.HPLC of Formula: 2241400-93-9.

NF-κB-inducing kinase (NIK) is a protein kinase central to the noncanonical NF-κB pathway downstream from multiple TNF receptor family members, including BAFF, which has been associated with B cell survival and maturation, dendritic cell activation, secondary lymphoid organ development, and bone metabolism We report herein the discovery of lead chem. series of NIK inhibitors that were identified through a scaffold-hopping strategy using structure-based design. Electronic and steric properties of lead compounds were modified to address glutathione conjugation and amide hydrolysis. These highly potent compounds exhibited selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. Compound 4f is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro and reduce splenic marginal zone B cells in vivo.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Exceptional dual fluorescent, excited-state intramolecular proton-transfer (ESIPT) columnar liquid crystals characterized by J-stacking and large Stokes shifts, published in 2021-06-15, which mentions a compound: 693-67-4, mainly applied to phasmidic bissalicylideneaniline preparation columnar liquid crystal phase transition fluorescence, Product Details of 693-67-4.

Herein the synthesis, characterization, and ESIPT activity of a homologous series of novel phasmidic bis(N-salicylideneaniline) Col LCs. was reported. Optical microscopic, calorimetric and powder X-ray diffraction (XRD) studies evidence the occurrence of hexagonal columnar (Colh) phase having p6mm symmetry where the constituent slices result from the self-assembly of a pair of mesogens in a side-by-side manner facilitated by intense longitudinal π-π interactions. X-ray data confirm the absence of both directionally correlated tilting of the slices and transverse core-core interactions within the columns. Fluorescence probing clearly evidence the ESIPT occurring not only in DCM solution of the mesogens but also in their three-condensed states viz., solid, liquid crystal, and isotropic liquid phase; in general, two archetypal emission bands at ∼430 nm (weak) and ∼ 630 nm (strong) with large Stokes shifts (250-275 nm) of ESIPT phenomenon was observed The slow shift of emission maxima of the ESIPT fluorescence as a function of decreasing temperature without photoluminescence quenching coupled with the estimated tilt angle (θ) of the slices normal to the columnar axis (37 to 42°), from the XRD data, confirmed the formation of so-called Scheibe or J-aggregates. The redox activity, metal ion sensing ability, and solvatochromism of the mesogens was also investigated. The study suggests that these ESIPT Col LCs with band-gap of about 3 eV can be regarded as wide-bandgap semiconducting materials having the electronic characteristics falling between those of conventional semiconductors and insulators.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Computed Properties of C11H23Br.Cruz, Daniel A.; Sinka, Victoria; de Armas, Pedro; Steingruber, Hugo Sebastian; Fernandez, Israel; Martin, Victor S.; Miranda, Pedro O.; Padron, Juan I. published the article 《Iron(II) and Copper(I) Control the Total Regioselectivity in the Hydrobromination of Alkenes》 about this compound( cas:693-67-4 ) in Organic Letters. Keywords: alkyl bromide preparation regioselective; alkene hydrobromination. Let’s learn more about this compound (cas:693-67-4).

A new method that allowed the complete control of the regioselectivity of the hydrobromination reaction of alkenes was described. Herein, a radical procedure with TMSBr and oxygen as common reagents, where the formation of the anti-Markovnikov product occurs in the presence of ppm amounts of the Cu(I) species and the formation of the Markovnikov product occurred in the presence of 30 mol % iron(II) bromide was reported. D. functional theory calculations combined with Fukui’s radical susceptibilities support the obtained results.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Chemodivergent Synthesis of One-Carbon-Extended Alcohols via Copper-Catalyzed Hydroxymethylation of Alkynes with Formic Acid.Formula: C14H9Cl.

Here an intriguing strategy for the chemodivergent copper-catalyzed hydroxymethylation of alkynes RCCR1 (R = Ph, cyclopropyl, thiophen-2-yl, etc.; R1 = Ph, H, 3-fluorophenyl, 2-fluorophenyl, etc.) and R2CCH [R2 = 4-(4-methylphenyl)phenyl, 4-(4-fluorophenyl)phenyl, 4-(thiophen-2-yl)phenyl, etc.] and 9-ethynylphenanthrene with formic acid and hydrosilane has been developed. By simply tuning the amount of formic acid and reaction temperature, distinct one-carbon-extended primary alcs., i.e., allylic alcs. (E)/(Z)-RCH=C(R1)CH2OH and β-branched alkyl alcs., (S)-R2CH(CH3)CH2OH and (S)-2-(phenanthren-9-yl)propan-1-ol were produced with high levels of Z/E-, regio-, and enantioselectivity.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 4-Chloro-4′-ethynyl-1,1′-biphenyl. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 4-Chloro-4′-ethynyl-1,1′-biphenyl, is researched, Molecular C14H9Cl, CAS is 57399-11-8, about Discovery of a novel series of N-hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality. Author is Singh, Sarbjit; Goo, Ja-Il; Noh, Hyojin; Lee, Sung Jae; Kim, Myoung Woo; Park, Hyejun; Jalani, Hitesh B.; Lee, Kyeong; Kim, Chunsook; Kim, Won-Ki; Ju, Chung; Choi, Yongseok.

Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited H2O2-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Bromoundecane( cas:693-67-4 ) is researched.Recommanded Product: 1-Bromoundecane.Congdon, Molly; Fritzemeier, Russell G.; Kharel, Yugesh; Brown, Anne M.; Serbulea, Vlad; Bevan, David R.; Lynch, Kevin R.; Santos, Webster L. published the article 《Probing the substitution pattern of indole-based scaffold reveals potent and selective sphingosine kinase 2 inhibitors》 about this compound( cas:693-67-4 ) in European Journal of Medicinal Chemistry. Keywords: alkylindolyl oxadiazolylpyrrolidine preparation sphingosine kinase inhibition SAR mol docking; Molecular docking; SAR; SphK2; Sphingosine; Sphingosine 1-phosphate; Sphingosine kinase. Let’s learn more about this compound (cas:693-67-4).

Elevated levels of sphingosine 1-phosphate (S1P) and increased expression of sphingosine kinase isoforms (SphK1 and SphK2) have been implicated in a variety of disease states including cancer, inflammation, and autoimmunity. Selective inhibition of either SphK1 or SphK2 has been demonstrated to be effective in modulating S1P levels in animal models. Previously, authors reported a SphK2 naphthalene-based selective inhibitor, (R)-2-(3-(7-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride, which displays approx. 7-fold selectivity for hSphK2 over hSphK1 and has a SphK2 Ki value of 1.0μM. To improve SphK2 potency and selectivity, author’s designed, synthesized, and evaluated a series of indole-based compounds derived from (R)-2-(3-(7-(pentyloxy)naphthalen-2-yl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide hydrochloride. After investigating substitution patterns around the indole ring, author’s discovered that 1,5-disubstitution promoted optimal binding in the SphK2 substrate binding site and subsequent inhibition of enzymic activity. Author’s studies led to the identification of I (SphK2 Ki = 90 nM, >110 fold selective for SphK2 over SphK1). Mol. modeling studies revealed key nonpolar interactions with Val308, Phe548, His556, and Cys533 and hydrogen bonds with both Asp211 and Asp308 as responsible for the high SphK2 inhibition and selectivity.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Shuai, Xiaomin; Cai, Zhiqiang; Zhao, Xinyu; Chen, Yujie; Zhang, Qian; Ma, Ziwei; Hu, Junjie; Sun, Tao; Hu, Shaoqiang published the article 《A new stationary phase for capillary gas chromatography: Calix[4]resorcinarene functionalized with imidazolium cationic units》. Keywords: capillary gas chromatog stationary phase imidazolium functionalized.They researched the compound: 1-Bromoundecane( cas:693-67-4 ).Reference of 1-Bromoundecane. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:693-67-4) here.

A novel calix[4]resorcinarene-based ionic liquid (C4RA-2IL) was synthesized, structurally characterized, and statically coated on capillary column as stationary phase for capillary gas chromatog. (GC). The column efficiency of the C4RA-2IL column is 3345 plates m-1, which are determined by n-dodecane at 120 °C. Based on its McReynolds constants, the C4RA-2IL column showed moderate polarity. Particularly, the C4RA-2IL column show high separation performance for a wide range of analytes and some difficult separation of meta/para-isomers. Moreover, it exhibited excellent selectivity for critical aromatic isomers of chloroaniline, bromaniline, iodoaniline, toluidine and xylidine isomers and shows advantageous separation capability over the com. polysiloxane stationary phase. This work presents a promising future of calixarene-based ionic liquid as a new type of stationary phase in GC separations

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem