Tag: M.W:400-500

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Redox-active films formed by electrochemical reduction of solutions of C60 and platinum complexes, published in 2002-07-31, which mentions a compound: 15227-42-6, mainly applied to redox active film electrochem reduction solution fullerene platinum complex; pyridine chloro platinum complex ferrocene electroreduction redox active film, Quality Control of cis-Dichlorobis(pyridine)platinum(II).

Electroreduction of a toluene-acetonitrile (4:1 volume/volume) solution of C60 and cis-Pt(py)2Cl2 in the presence of 0.10M tetra(n-butyl)ammonium perchlorate as supporting electrolyte produces a black, redox active film that coats the electrode surface. This film retains its redox activity when transferred to an acetonitrile solution that contains only the supporting electrolyte, 0.10M tetra(n-butyl)ammonium perchlorate. The film was characterized by IR spectroscopy, laser desorption mass spectrometry, and XPS spectroscopy. The formation of this film is dependent on the platinum complex used as precursor and on the potential range used during film growth. No film growth is observed when Pt(bipy)Cl2, Pt(py)2I2, cis-Pt(PPh3)2Cl2 or trans-Pt(py)2Cl2 were used as precursors, but {Pt(μ-Cl)Cl(C2H4)}2 is a useful precursor which allows film growth at less neg. potentials. Chem. prepared C60Pt1 is also electrochem. active when precipitated on a platinum electrode. The formation of an electroactive film from the electroreduction of C70 and cis-Pt(py)2Cl2 is also reported.

The article 《Redox-active films formed by electrochemical reduction of solutions of C60 and platinum complexes》 also mentions many details about this compound(15227-42-6)Quality Control of cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Computed Properties of C10H10Cl2N2Pt. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Suppression of growth by platinum(II) complexes in relation to their structure. Author is Ivanov, V. B.; Chel’tsov, P. A.; Shchelokov, R. N..

Structure-activity studies with 17 Pt-containing complexes showed a correlation between the ability of these complexes to inhibit cell division in corn roots and their known antitumor activities. For the more active compounds C90 (90% suppression of root growth rate) for 3 days was 3 × 10-6M, close to the corresponding amount for highly active inhibitors of other chem. classes. Possible use of the root growth rate to study the biol. activity of Pt-containing complexes is suggested. Structure-activity relations were discussed.

The article 《Suppression of growth by platinum(II) complexes in relation to their structure》 also mentions many details about this compound(15227-42-6)Computed Properties of C10H10Cl2N2Pt, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Electric Literature of C6H6N2O. The article 《ESR of hot ions: low spin platinum(III) complex ions produced by γ-irradiation》 in relation to this compound, is published in Bulletin of the Chemical Society of Japan. Let’s take a look at the latest research on this compound (cas:15227-42-6).

Tervalent Pt complex ions were observed by ESR upon γ-irradiation of both bivalent and quadrivalent complexes. From their g-values, the tervalent complex ions can be classified into 2 types, one axially sym. and the other orthorhombic, the former having typical g-values of 2(g‖) and 2.4(g.perp.), and the latter a g1-value slightly lower than the free electron value of 2.0023. The hyperfine interaction due to 195Pt is 1 order of magnitude larger than that in Co complexes with 3d7 low spin configuration, indicating that the configuration interaction involving 6s-orbital is more important than that for 3d transition metal complexes involving 4s-orbital, and that 5d electrons penetrate deeply into inner shells, resulting in core polarization.

The article 《ESR of hot ions: low spin platinum(III) complex ions produced by γ-irradiation》 also mentions many details about this compound(15227-42-6)Formula: C10H10Cl2N2Pt, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Quality Control of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Discovery and resistance mechanism of a selective CDK12 degrader. Author is Jiang, Baishan; Gao, Yang; Che, Jianwei; Lu, Wenchao; Kaltheuner, Ines H.; Dries, Ruben; Kalocsay, Marian; Berberich, Matthew J.; Jiang, Jie; You, Inchul; Kwiatkowski, Nicholas; Riching, Kristin M.; Daniels, Danette L.; Sorger, Peter K.; Geyer, Matthias; Zhang, Tinghu; Gray, Nathanael S..

Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small mols. targeting CDK12 has been challenging due to the high degree of homol. between kinase domains of CDK12 and other transcriptional CDKs, most notably CDK13. In the present study, the rational design and characterization of a CDK12-specific degrader, BSJ-4-116 (I), is reported. BSJ-4-116 selectively degraded CDK12 as assessed through quant. proteomics. Selective degradation of CDK12 resulted in premature cleavage and poly(adenylation) of DDR genes. Moreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single agent against cell lines resistant to covalent CDK12 inhibitors. Two point mutations in CDK12 were identified that confer resistance to BSJ-4-116, demonstrating a potential mechanism that tumor cells can use to evade bivalent degrader mols.

The article 《Discovery and resistance mechanism of a selective CDK12 degrader》 also mentions many details about this compound(882562-40-5)Quality Control of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, you can pay attention to it or contacet with the author([email protected]; [email protected]; [email protected]; [email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Experimental and quantum-chemical studies of 15N NMR coordination shifts in palladium and platinum chloride complexes with pyridine, 2,2′-bipyridine and 1,10-phenanthroline, published in 2006-02-28, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Name: cis-Dichlorobis(pyridine)platinum(II).

Pd and Pt chloride complexes with pyridine (py),2,2′-bipyridine (bpy) and 1,10-phenanthroline (phen), trans-/cis-[M(py)2Cl2], [M(py)4]Cl2, trans-/cis-[M(py)2Cl4], [M(bpy)Cl2], [M(bpy)Cl4], [M(phen)Cl2], [M(phen)Cl4], where M = Pd, Pt, was studied by 1H, 195Pt, and 15N NMR. The 90-140 ppm low-frequency 15N coordination shifts are discussed in terms of such structural features of the complexes as the type of platinide metal, oxidation state, coordination sphere geometry and the type of ligand. The results of quantum-chem. NMR calculations were compared with the exptl. 15N coordination shifts, well reproducing their magnitude and correlation with the mol. structure.

The article 《Experimental and quantum-chemical studies of 15N NMR coordination shifts in palladium and platinum chloride complexes with pyridine, 2,2′-bipyridine and 1,10-phenanthroline》 also mentions many details about this compound(15227-42-6)Name: cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Product Details of 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity. Author is Webster, Lorraine K.; Deacon, Glen B.; Buxton, David P.; Hillcoat, Brian L.; James, Alison M.; Roos, Ian A. G.; Thomson, Robin J.; Wakelin, Laurence P. G.; Williams, Tracey L..

The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.

Different reactions of this compound(cis-Dichlorobis(pyridine)platinum(II))Product Details of 15227-42-6 require different conditions, so the reaction conditions are very important.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Reactivity of geometric isomers of (-)-dichloropyridine(methyl p-tolyl sulfoxide)platinum(II) by optical rotatory dispersion, the main research direction is platinum sulfoxide pyridine complex substitution nucleophile; isomerization platinum sulfoxide pyridine complex reaction nucleophile.Formula: C10H10Cl2N2Pt.

The reactions of the optically active geometric isomers of (-)-[Pt(Me-p-TolSO)(Py)Cl2] with several nucleophilic reagents (py, Ph3PS, Ph3P, Ph3As, and Me2SO) were studied by ORD, IR spectroscopy, and 1H and 31P NMR spectroscopy. A mechanism for the reaction is proposed.

The article 《Reactivity of geometric isomers of (-)-dichloropyridine(methyl p-tolyl sulfoxide)platinum(II) by optical rotatory dispersion》 also mentions many details about this compound(15227-42-6)Formula: C10H10Cl2N2Pt, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Author is Kwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B.; Abraham, Brian J.; Reddy, Jessica; Ficarro, Scott B.; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E.; Hannett, Nancy M.; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S.; Weng, Andrew P.; Brown, Jennifer R.; Benes, Cyril H.; Marto, Jarrod A.; Young, Richard A.; Gray, Nathanael S..

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacol. inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here the authors present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide anal. in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumor cells. Pharmacol. modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state.

The article 《Targeting transcription regulation in cancer with a covalent CDK7 inhibitor》 also mentions many details about this compound(882562-40-5)Name: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes, published in 1978, which mentions a compound: 15227-42-6, mainly applied to chloropyridineplatinum complex oxidation reduction kinetics; pyridinechloroplatinum complex oxidation reduction kinetics; platinum pyridine complex oxidation reduction, Name: cis-Dichlorobis(pyridine)platinum(II).

The kinetics of oxidation of cis-[PtCl2L2] (L = py, 3-methyl-, 3- and 4-chloro-, 3- and 4-cyanopyridine) by [AuCl4]- in the presence of [NEt4]Cl and of reduction of cis-[PtCl4L2] by [NEt4]I were studied in MeCN. The rate law for the oxidation reaction was rate = k3[PtCl2L2][AuCl4-][Cl-], where k3 was unaffected by changes in L and had a value ∼100 times higher than that previously found for related phenanthrolineplatinum(II) complexes. The rate law for the reduction reaction was rate = k2[PtCl4L2][I-], where k2 was influenced by the basicity of L, as in related phenanthrolineplatinum(IV) complexes. The kinetic results were discussed in terms of σ and π interactions between the Pt and L.

The article 《Kinetics of oxidation of dichlorobis(substituted pyridine)platinum(II) and of reduction of tetrachlorobis(substituted pyridine)platinum(IV) complexes》 also mentions many details about this compound(15227-42-6)Name: cis-Dichlorobis(pyridine)platinum(II), you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C10H10Cl2N2Pt. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Infrared spectra of some transition metal halide complexes with pyridine. Author is Hatakeyama, Suekichi; Sato, Choei.

Assignments are given for the ir spectra of metal-pyridine complexes of the type NiX2.npy, CuX2.2py (X = Cl, Br; n = 1,2,4) and cis-, trans-PtCl2.2py in the 200-1610-cm-1 region. For a series of Ni complexes studied, the ν(Ni-N) vibrations occur at ∼240 cm-1. Cu complexes, on the other hand, show the ν(Cu-N) band near 270 cm-1. Among pyridine vibrations the ν4, ν9, ν10 and ν27, ring deformation vibrations, and the ν16, H in-plane deformation vibration, shift significantly to a higher frequency by complex formation. Among the rest, the ν10, in-plane ring deformation vibration, is the most sensitive upon complex formation.

The article 《Infrared spectra of some transition metal halide complexes with pyridine》 also mentions many details about this compound(15227-42-6)Formula: C10H10Cl2N2Pt, you can pay attention to it, because details determine success or failure

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem