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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Electrochemical reduction of geometric isomers of [Pt(C5H5N)2Cl2Br2] on a dropping mercury electrode in propylene carbonate solutions, published in 1996, which mentions a compound: 15227-42-6, mainly applied to electrochem reduction geometric isomer platinum complex; redox reaction coordinated pyridine platinum complex; pyridine halo platinum complex electroreduction; bromo chloro pyridine platinum complex electroreduction, Application of 15227-42-6.

The method of classical polarog. on a dropping Hg electrode in propylene carbonate was used to study the reduction of the isomeric complexes of Pt(IV) of type [Pt(C5H5N)2Cl2Br2] and of Pt(II) of type [Pt(C5H5N)2X2], where X = Cl, Br. The reduction of cis,cis,trans-[Pt(C5H5N)2Cl2Br2] and of cis,trans,cis-[Pt(C5H5N)2Cl2Br2] occurs according to an electrochem.-chem. mechanism during which, and following the 1-electron reduction of Pt(IV) to Pt(III), there occurs an intramol. redox process with participation of coordinated pyridine.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Science Reports of the Hirosaki University called Infrared spectra of some transition metal halide complexes with pyridine, Author is Hatakeyama, Suekichi; Sato, Choei, the main research direction is transition metal halide pyridine complex; pyridine transition metal halide IR; IR transition metal halide pyridine; nickel halide pyridine complex IR; copper halide pyridine complex IR; platinum halide pyridine complex IR; halide metal pyridine complex IR.Product Details of 15227-42-6.

Assignments are given for the ir spectra of metal-pyridine complexes of the type NiX2.npy, CuX2.2py (X = Cl, Br; n = 1,2,4) and cis-, trans-PtCl2.2py in the 200-1610-cm-1 region. For a series of Ni complexes studied, the ν(Ni-N) vibrations occur at ∼240 cm-1. Cu complexes, on the other hand, show the ν(Cu-N) band near 270 cm-1. Among pyridine vibrations the ν4, ν9, ν10 and ν27, ring deformation vibrations, and the ν16, H in-plane deformation vibration, shift significantly to a higher frequency by complex formation. Among the rest, the ν10, in-plane ring deformation vibration, is the most sensitive upon complex formation.

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Berezin, V. I.; Ganin, V. V.; Kovrikov, A. B.; Lipnitskii, I. V.; Rogalevich, N. L. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

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COA of Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactions of potassium tetrachloroplatinate(II) with pyridine derivatives in dimethylformamide and synthesis of potassium trichloro(pyridine)platinum(II). Author is Kong, Pi-Chang; Rochon, F. D..

The reactions of K2PtCl4 with pyridine derivatives L (L = py = pyridine, pic = picoline, and lut = lutidine) were studied in DMF. K[PtLCl3] (I) were isolated and the yield decreased with the order, 2,4-lut = 2-pic > 2,6-lut > 4-pic = py, which can be correlated to the steric hindrance of the ortho Me groups. Cis-[PtL2Cl2] (II) is the final product of the reactions. Trans-[PtL2Cl2] (III) can also be obtained from a DMF solution of [Pt(L)4]Cl2 (L = py) at room temperature A comparison of the above reactions in H2O and in DMF was also made.

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Application of 882562-40-5. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Discovery and resistance mechanism of a selective CDK12 degrader. Author is Jiang, Baishan; Gao, Yang; Che, Jianwei; Lu, Wenchao; Kaltheuner, Ines H.; Dries, Ruben; Kalocsay, Marian; Berberich, Matthew J.; Jiang, Jie; You, Inchul; Kwiatkowski, Nicholas; Riching, Kristin M.; Daniels, Danette L.; Sorger, Peter K.; Geyer, Matthias; Zhang, Tinghu; Gray, Nathanael S..

Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small mols. targeting CDK12 has been challenging due to the high degree of homol. between kinase domains of CDK12 and other transcriptional CDKs, most notably CDK13. In the present study, the rational design and characterization of a CDK12-specific degrader, BSJ-4-116 (I), is reported. BSJ-4-116 selectively degraded CDK12 as assessed through quant. proteomics. Selective degradation of CDK12 resulted in premature cleavage and poly(adenylation) of DDR genes. Moreover, BSJ-4-116 exhibited potent antiproliferative effects, alone and in combination with the poly(ADP-ribose) polymerase inhibitor olaparib, as well as when used as a single agent against cell lines resistant to covalent CDK12 inhibitors. Two point mutations in CDK12 were identified that confer resistance to BSJ-4-116, demonstrating a potential mechanism that tumor cells can use to evade bivalent degrader mols.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Validation Study, Journal of Inorganic Biochemistry called The RP-HPLC measurement and QSPR analysis of log Po/w values of several Pt(II) complexes, Author is Platts, James A.; Oldfield, Steven P.; Reif, Maria M.; Palmucci, Alessandra; Gabano, Elisabetta; Osella, Domenico, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The n-octanol/water partition coefficient, log Po/w, for a set of 24 Pt(II)-complexes was estimated by means of reversed-phase high performance liquid chromatog. (RP-HPLC) technique using a C18 (ODS, octadecyl silane) column as a stationary phase and water/methanol mixtures as mobile phases. Based on the known log P o/w of several Pt(II)-complexes, the authors set a method to correlate the partition coefficient of this kind of complexes with the corresponding retention parameters. The best result was obtained from extrapolation to 0% of the organic modifier (MeOH) of the aqueous eluant. A quant. structure-property relationship (QSPR) was constructed using mol. descriptors derived from d. functional theory (DFT) calculations, which was found to correlate and predict these values with good accuracy. The use of DFT calculations is required because group-additive methods fail due to lack of values for appropriate fragments for many Pt(II)-complexes.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor platinum compounds. Relation between structure and activity.Product Details of 15227-42-6.

A pair of cis leaving groups is necessary but not sufficient for anticancer activity in Pt(II) complexes. The complex should be neutral and the lability of the leaving groups should be about that of Cl in cis-dichlorodiammineplatinum(II) [15663-27-1]. The other ligands should be relatively inert and neutral. Amines are preferred, although varying their structure has not given a clear pattern. However the activity of compounds containing alicyclic amines indicates that some Pt compounds may be highly selective.

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Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.

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There is considerable interest in the development of novel platinum-based anticancer drugs that overcome the disadvantages associated with the widely used drug cisplatin, which are its inactivity against some types of tumors and its toxic side effects. In this study we show the suitability of normal Raman spectroscopy (NRS) and surface enhanced Raman spectroscopy (SERS), assisted by d. functional theor. (DFT) calculations, for the characterization of Pt complexes. The Pt complexes studied include the established drugs cisplatin and carboplatin, as well as five novel Pt complexes with anticancer activity. DFT calculations at the B3LYP/LanL2DZ level are a good prediction of the exptl. NRS spectra of small and medium sized Pt complexes. The use of SERS allows the investigation of Pt complexes at physiol. concentrations, and the binding strengths of the different ligands can be determined The formation of pos. charged hydrolysis products may be necessary for SERS activity. The existing group in the hydrolysis reaction can be identified.

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Computed Properties of C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Reactions of potassium tetrachloroplatinate(II) with pyridine derivatives in dimethylformamide and synthesis of potassium trichloro(pyridine)platinum(II). Author is Kong, Pi-Chang; Rochon, F. D..

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