Tag: M.W:400-500

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Quality Control of cis-Dichlorobis(pyridine)platinum(II).Kotowski, M.; Palmer, D. A.; Kelm, H. published the article 《Volumes of activation for the substitution reactions of cis- and trans-[PtL2(Cl)X] with pyridine in various solvents》 about this compound( cas:15227-42-6 ) in Inorganic Chemistry. Keywords: platinum complex substitution kinetics pyridine; volume activation platinum complex substitution; solvent effect platinum complex substitution. Let’s learn more about this compound (cas:15227-42-6).

The pressure dependence of the 2nd-order rate constant for the substitution of pyridine for Cl in trans-[Pt(py)2(Cl)(NO2)] was measured in the solvents nitromethane, methanol, ethanol, and dichloromethane. The resp. ΔV*exptl. values were calculated to be -6.2 ± 0.4 at 10°, -8.8 ± 0.6 at 25°, -13.1 ± 0.8 at 25°, and -19.8 ± 1.7 cm3 mol-1 att 25°. The ΔVexptl. values for the corresponding reactions of cis-[Pt(py)2(Cl)(NO2)] and trans-[Pt(PEt3)2Cl2] in methanol at 25° are -5.5 ± 0.5 and -13.6 ± 0.8 cm3 mol-1, resp. These ΔV*exptl.’s were found to be only slightly temperature dependent. The activation parameters ΔH*2 and ΔS*2 were also determined for each reaction. The volume change associated with the partial formation of the Pt-pyridine bond was estimated to be -4 ± 1 cm3 mol-1. A qual. explanation of the solvent dependence of ΔV*exptl. is also given.

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Tetrahydroisoquinoline – Wikipedia,
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Vekki, D. A.; Skvortsov, N. K. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Category: tetrahydroisoquinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane in the presence of the complexes of Pt(II), Pd(II) and Rh(I) is explored. In the presence of Pt catalyst, hydrosilylation of α-methylstyrene occurs predominantly giving β-adduct, while on Pd catalysts proceeds reduction of α-methylstyrene and on Rh catalysts both processes take place. In the reaction mixture proceeds disproportion and dehydro-condensation of 1,1,3,3-tetramethyldisiloxane that gives long chain linear and cyclic siloxanes HMe2Si(OSiMe2)nH and (-OSiMe2-)m (n = 2-6, m = 3-7), resp. Platinum catalysts promotes formation of linear siloxanes, while both Rh and Pd catalysts afford linear and cyclic siloxanes as well. Structure of intermediate metallo-complexes was studied.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Category: tetrahydroisoquinoline. The article 《Cytostatic trans-platinum(II) complexes》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:15227-42-6).

The unusual cytostatic properties of trans-Pt(II) complexes of pyridine, trans-[PtCl2L2] (L = pyridine, 4-methylpyridine), are reported. The complexes demonstrate increased cytostatic activity to L1210 leukemia cells over the cis-pyridine analogs and had activity equivalent to that of cisplatin. The results have implications for the design of structurally novel Pt antitumor agents.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Might telomerase enzyme be a possible target for trans-Pt(II) complexes?, Author is Colangelo, Donato; Ghiglia, AnnaLisa; Viano, Ilario; Mahboobi, Homa; Ghezzi, AnnaRita; Cassino, Claudio; Osella, Domenico, the main research direction is trans platinum antitumor complex telomerase target.Product Details of 15227-42-6.

Telomerase is a ribonucleoprotein polymerase that synthesizes telomeric DNA (TTAGGG) repeats. Previously, we have studied the effect on telomerase enzyme of several cis-platinum(II) complexes bearing aromatic amines as bulky carrier groups. All these complexes possess cis-geometry, according to the Cleare and Hoschele’s rule. Since recent reports have dealt with the anti-cancer activity of trans-platinum compounds, in this study we have investigated the Farrell’s prototypical trans-[Pt(Cl)2(pyridine)2], hereafter called trans-PtPy, to understand whether it may possess any anti-telomerase activity. The trans-PtPy has low water solubility and requires DMSO as co-solvent, thus making the biol. tests problematic. The effect of trans-PtPy on MCF-7 cell line concerning log-term telomerase inhibition, telomerase-related gene expression, viability, and apoptosis was evaluated. In a cell-free biochem. assay, trans-PtPy showed significant and dose-dependent inhibition of semi-purified telomerase. The bulk of data indicate that trans-PtPy acts as a non-properly selective anti-proliferative agent, although it shows an initial telomerase inhibitory effect. Telomere length reduction seems not to be the main mechanism causing the observed cell apoptosis. For comparison purpose, results on cis-[Pt(Cl)2(pyridine)2] are reported.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Safety of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Experimental criteria for the applicability of the group model to stretching vibrations of the dichloroplatinum fragment in square planar complexes.

A correlation was found between the Pt-Cl bond length difference, Δr, and the distance, Δν, between the doublet components of the stretching vibration νClPt in cis[PtCl2LL’] complexes with 2 different ligands, L and L’. For Δr = 0-0.025 Å, a constant splitting Δν = 15-25 cm-1 was observed, but for Δr >0.03 Å Δν increased linearly with increasing Δr. The difference was explained in terms of sym. and asym. Pt-Cl bonds.

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Tetrahydroisoquinoline – Wikipedia,
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Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The effects of single administration of an antitumor platinum compound on ornithine decarboxylase activity in certain tissues of mice bearing L1210 leukemia. Author is Morris, Carl R.; Atkins, Loretta M.; Gale, Glen R..

A single dose of cis-dichloro(dipyridine)platinum(II) [15227-42-6], when given to mice bearing 1-day-old L1210 leukemia, suppressed the increase of spleen and liver ornithine decarboxylase (ODC) [9024-60-6] activity which occurs concomitantly with development of the leukemia. The inhibition of ODC, the rate-limiting enzyme in polyamine synthesis, appeared to correlate with the prolonged chemotherapeutic efficacy of a single dose of the platinum complex. These observations suggest an addnl. mechanism by which platinum complexes express their antitumor actions and, in addition, support the view that polyamine synthesis and excretion patterns can be used as predictors of chemotherapeutic response.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Molecular Photochemistry called Mechanism of cis-trans photoisomerization of dichlorodipyridineplatinum,(II), Author is Moggi, Luca; Varani, Graziano; Sabbatini, Nanda; Balzani, Vincenzo, which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Computed Properties of C10H10Cl2N2Pt.

The photochem. behavior of cis- and trans-Pt(py)2Cl2 in CHCl3 solutions has been investigated using 313 nm light. The cis isomer undergoes 2 simultaneous photoreactions, one being an intramol. photoisomerization process (Φisom ∼0.04) and the other a photodissociation reaction involving the pyridine ligand (Φdiss ∼ 0.025). This latter photoreaction provides an intermol. path for the cis → trans isomerization since its products (namely, free pyridine and Pt-containing species) recombine thermally to give cis- and trans-Pt(py)2Cl2 in a 2:1 ratio. The trans isomer undergoes photoisomerization and pyridine release but with much lower quantum yields (∼0.001). Qual. results concerning the photochem. behavior of the above complexes in MeOH solutions upon 254 or 313 nm irradiation are also reported.

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Tetrahydroisoquinoline – Wikipedia,
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COA of Formula: C10H10Cl2N2Pt. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Spectroscopic study of square planar compounds of platinum(II) and palladium(II) with substituted pyridines. I. Vibrations of the ligands. Author is Pfeffer, M.; Braunstein, P.; Dehand, J..

The ir spectra of methylpyridine Pt(II) and Pd(II) complexes were observed at 400-1700 cm-1. Bands were obtained which were displaced by coordination of the ligand or which were characteristics of cis and trans configurations of the planar complexes.

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Tetrahydroisoquinoline – Wikipedia,
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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Name: cis-Dichlorobis(pyridine)platinum(II).Martin, Marilyn; Krogh-Jespersen, Mary Beth; Hsu, Martha; Tewksbury, John; Laurent, Michel; Viswanath, Kasi; Patterson, Howard published the article 《Multistate luminescence, absorption and MCD studies of the relative energies of d → d, d → π*, and n,π → π* transitions for the cis and trans isomers of dichlorobis(pyridine)platinum(II)》 about this compound( cas:15227-42-6 ) in Inorganic Chemistry. Keywords: UV luminescence platinum chloride pyridine; magnetic CD platinum chloride pyridine. Let’s learn more about this compound (cas:15227-42-6).

Luminescence, absorption, and magnetic CD (MCD) experiments are reported for cis- and trans-dichlorobis(pyridine)platinum(II). For the trans isomer, an anal. of the temperature dependence of the lifetimes and luminescence intensities indicates that emission at 605 nm is from 2 excited π* states separated by 240 cm-1. For the cis isomer, time-resolved spectroscopy allowed observation of 2 emission bands at 600 and 700 nm, which were assigned from their lifetimes to π* → d and d → d transitions, resp. Further, temperature dependent lifetime studies show that the 600-nm band (π* → d) is from 2 electronic states separated by 200 cm-1. The absorption spectra of both isomers were measured at room and low temperatures in solution, in glasses, and in KCl pellets. From a comparison with the pyridine and Pt(NH3)2Cl2 absorption and MCD spectra and MO calculations, the observed absorption bands for Pt(py)2Cl2 are assigned as d → d, d → π*, and n, π → π* transitions. For the cis isomer the lowest unoccupied mol. orbital is a d metal orbital.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Bulletin of the Chemical Society of Japan called ESR of hot ions: low spin platinum(III) complex ions produced by γ-irradiation, Author is Amano, Chikara; Fujiwara, Shizuo, the main research direction is ESR platinum complex gamma irradiation; hot ion platinum complex ESR.Formula: C10H10Cl2N2Pt.

Tervalent Pt complex ions were observed by ESR upon γ-irradiation of both bivalent and quadrivalent complexes. From their g-values, the tervalent complex ions can be classified into 2 types, one axially sym. and the other orthorhombic, the former having typical g-values of 2(g‖) and 2.4(g.perp.), and the latter a g1-value slightly lower than the free electron value of 2.0023. The hyperfine interaction due to 195Pt is 1 order of magnitude larger than that in Co complexes with 3d7 low spin configuration, indicating that the configuration interaction involving 6s-orbital is more important than that for 3d transition metal complexes involving 4s-orbital, and that 5d electrons penetrate deeply into inner shells, resulting in core polarization.

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Tetrahydroisoquinoline – Wikipedia,
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