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Ivanov, V. B.; Chel’tsov, P. A.; Shchelokov, R. N. published the article 《Biological effect of platinum(II) complexes with two different neutral ligands of cis-[PtNH3LCl2] type》. Keywords: platinum diamine complex antimitotic; corn mitosis platinum diamine complex.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).HPLC of Formula: 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The effect of Pt complexes on the growth of corn roots was studied. Two types of Pt complexes were used: (1) cis-[PtNH3LCl2], where L = DMSO, C2H4, acetonitrile, pyridine, and benzylamine, and (2) cis-[PtL2Cl2], where L = pyridine, acetonitrile, and benzylamine. The growth-inhibitory effects of all complexes were lower than that of cis-dichlorodiammine platinum [15663-27-1]. The only compound which showed distinct inhibition of mitosis was cis-[PtNH3(PhCH2NH2)Cl2] [79371-82-7]. The antimitotic activity of the Pt diamine complexes was apparently associated with the cis-diamine fragment of the mol.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Solid-phase thermal transformations of platinum(IV) aminate complexes, the main research direction is thermal reaction onium chloroplatinate; platinate chloro onium thermal reaction.Related Products of 15227-42-6.

The thermal behavior of onium chloroplatinates of the type (AH)2[PtCl6] (A = NH3, MeNH2, 0.5 en, piperidine, py, γ-picoline, NH2Ph, p-toluidine, quinoline, 0.5 2,2′-bipyridine) was studied by derivatog. and IR spectral anal. The heating of solid (AH)2[PtCl6] led to the formation of trans-PtL2Cl4 (L = py, γ-picoline) and cis-PtQ2Cl4 (Q = p-toluidine) and subsequently to the formation of cis-PtA2Cl2. When (AH)2[PtCl6] (A = piperidine) was heated (AH)2[PtCl4] was formed. These results were compared with those for the corresponding palladates.

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Tetrahydroisoquinoline – Wikipedia,
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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine), published in 1993-09-21, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Electric Literature of C10H10Cl2N2Pt.

The DNA binding properties of cis- and trans-[PtCl2(pyridine)2] have been examined and compared with their NH3 analogs, cis- and trans-DDP. The presence of a planar ligand reduces the rates of DNA binding but does not greatly affect the overall conformation of CT DNA, as measured by CD spectroscopy. The sequence specificity of trans-[PtCl2(py)2] includes alternating purine-pyrimidine sequences. The sequence specificity is further different between the two pyridine isomers, and the steric effects of two cis-pyridine groups are demonstrated by the appearance of relatively few binding sites in the 49-bp duplex. The effects of the pyridine ligand are further manifested by a greatly enhanced DNA-DNA interstrand crosslinking efficiency for the trans isomer, with a cross-link per adduct frequency of between 0.14 and 0.23, depending on the rb of the sample. The unwinding of closed circular pUC19 DNA by trans-[PtCl2(pyridine)2] is also more efficient than that by either DDP isomer. In contrast, little unwinding is induced by cis-[PtCl2(pyridine)2]. These results invert the standard cis/trans structure-activity relationships observed previously for [PtCl2(NH3)2]. The results are discussed with respect to the previously demonstrated effect of activation of the trans-platinum geometry using sterically hindered ligands.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Radiosensitization of EMT6 cells by four platinum complexes, the main research direction is radiosensitization EMT cell platinum complex; oxygen radiosensitization platinum complex.Product Details of 15227-42-6.

The radiosensitization of oxygenated and hypoxic exponentially growing EMT6 cells in vitro was measured. The dose modifying factors obtained with 200 and 400 μM trans-bis(2-nitroimidazole)dichloroplatinum II (NIPt) in hypoxic cells were 1.5 and 2.1, resp. For trans-bis(2-amino-5-nitrothiazole)dichloroplatinum II (Plant) under the same conditions, the dose modifying factor was 1.5 at 200 μM and 1.8 at 400 μM. Neither compound sensitized oxygenated cells when tested under similar protocols. Unlike the trans complexes, (1,2-diamino-4-nitrobenzene)dichloroplatinum II (Plato) was cytotoxic toward the hypoxic cells in the absence of x-rays. The time course of cytotoxicity for 100 μM Plato in exponentially growing cells showed rapid killing of hypoxic cells, and much less toxicity toward oxygenated cells. In radiosensitization studies, dose modifying factors of 1.6 and 2.0 were found with 200 and 400 μM Plato, resp., in hypoxic cells. The compound did not sensitize aerobic cells. The well known Pt complex cis-dipyridinedichloroplatinum II (PyPt) represents a cis-Pt heterocyclic aromatic complex that does not have a nitro-functionality. The dose modifying factor obtained with 400 μM PyPt in hypoxic cells was 1.7. On a molar basis, the nitro-functional Pt complexes appear to be more effective as hypoxic cell radiosensitizers than the corresponding free ligands.

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Tetrahydroisoquinoline – Wikipedia,
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Formula: C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Conformational properties of purine and pyrimidine complexes of cis-platinum. Implications for platinum(II)-DNA crosslinking modes. Author is Kistenmacher, Thomas J.; Orbell, John D.; Marzilli, Luigi G..

The stereochem. properties of a variety of cis complexes of Pt(II) containing purine or pyrimidine ligands are examined The critical intramol. conformational parameters [the interbase dihedral angle and the base/coordination plane dihedral angles] are systematically studied and trends sought. Where intramol. interactions are determinative of the adopted mol. conformation, the nature of the steric demands imposed by increasing numbers of exocyclic functional groups contiguous to the Pt binding site are clearly of major importance for the antitumor activity.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Radiosensitization of EMT6 cells by four platinum complexes. Author is Teicher, Beverly A.; Rockwell, Sara; Lee, Jonathan B..

The radiosensitization of oxygenated and hypoxic exponentially growing EMT6 cells in vitro was measured. The dose modifying factors obtained with 200 and 400 μM trans-bis(2-nitroimidazole)dichloroplatinum II (NIPt) in hypoxic cells were 1.5 and 2.1, resp. For trans-bis(2-amino-5-nitrothiazole)dichloroplatinum II (Plant) under the same conditions, the dose modifying factor was 1.5 at 200 μM and 1.8 at 400 μM. Neither compound sensitized oxygenated cells when tested under similar protocols. Unlike the trans complexes, (1,2-diamino-4-nitrobenzene)dichloroplatinum II (Plato) was cytotoxic toward the hypoxic cells in the absence of x-rays. The time course of cytotoxicity for 100 μM Plato in exponentially growing cells showed rapid killing of hypoxic cells, and much less toxicity toward oxygenated cells. In radiosensitization studies, dose modifying factors of 1.6 and 2.0 were found with 200 and 400 μM Plato, resp., in hypoxic cells. The compound did not sensitize aerobic cells. The well known Pt complex cis-dipyridinedichloroplatinum II (PyPt) represents a cis-Pt heterocyclic aromatic complex that does not have a nitro-functionality. The dose modifying factor obtained with 400 μM PyPt in hypoxic cells was 1.7. On a molar basis, the nitro-functional Pt complexes appear to be more effective as hypoxic cell radiosensitizers than the corresponding free ligands.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Related Products of 15227-42-6. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Pyrrole thioaldehyde complexes of nickel, palladium and platinum. Author is Pogorzelec, Peter J.; Reid, David H.; Tocher, Derek A.; Wilton-Ely, D. E. T..

The coordination chem. of the unusual, pyrrole-stabilized thioaldehyde mols., 3,5-dimethylpyrrole-2-carbothioaldehyde (HSPyMeHMe) and 3,5-dimethyl-4-ethylpyrrole-2-carbothioaldehyde (HSPyMeEtMe) was studied with nickel, palladium and platinum in preparing [M(κ2-SPyMeRMe)2] (M = Ni, Pd, Pt; R = H, Et). The structure of the cyclometalated derivative [Pd(η2-C,N-C6H4CH2-2-NMe2)(κ2-SPyMeEtME)] was determined by x-ray diffraction.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Inorganica Chimica Acta called Synthesis of potential platinum(II) antitumor complexes: complexes containing bidentate pyridyl and imidazolyl donors, Author is Canty, Allan J.; Stevens, Elizabeth A., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Formula: C10H10Cl2N2Pt.

PtLCl2 [L = di-2-pyridylmethane, 3,3-bis(2-pyridyl)pentane, 2-(2-pyridyl)imidazole (I), N-methyl-2-(2-pyridyl)imidazole] were prepared and characterized by chem. anal., elec. conductivity, IR spectra, and inhibitory effects on cultures of L1210 mouse leukemia cells. The complex with L = I gave a 50% inhibiting dose similar to that of cis-Pt(NH3)2Cl2 and below the values of the other complexes; this suggests that further tests with tumor-bearing animals is warranted for this I complex with Pt.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of the American Chemical Society called Interaction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-label, Author is Chao, Yen Yau H.; Holtzer, Alfred; Mastin, Stephen H., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Formula: C10H10Cl2N2Pt.

The free-radical 4-amino-2,2,6,6-tetramethylpiperidinyl-1-oxy [14691-88-4] yields cis-Pt(ATMPO)2(NO3)2 [64716-94-5], which is used to label poly(L-glutamate) (I), poly(L-aspartate) (II), and poly(L-lysine) (III). Labeling occurs by displacement of nitrate by polymer side chains. EPR spectra of oriented films of labeled I are strongly anisotropic; several arguments suggest that the major cause is g anisotropy. Spectra of solutions, in several solvents, of labeled I are also anisotropic and monitor the helix-coil transition and polymer aggregation. Since monofunctional, side-chain labels show only isotropic motions, Pt must be bifunctionally anchored to adjacent carboxylates, requiring the label to follow backbone segmental motions. With shorter side chains (II) adjacent double anchoring is impossible; with longer side chains (III), flexibility reduces coupling to backbone motion; in each, therefore, spectra are isotropic. Chromophoric compounds, particularly cis-Pt(bipy)(H2O)2][NO3]2 [64800-95-9], are similarly used. Bifunctional attachment is evidenced by the absence of base-induced UV spectral shifts (characteristic of attachment of OH- to Pt) shown by label alone, and by similarity of the spectra of labeled polymer and labeled oxalate. Induced CD appears for α helix in the region of the chromophore π-π* bands; transition to random coil drastically reduces this CD. With extensively labeled polymer differences in the course of the helix-coil transition as monitored by CD in the backbone region with that monitored in the chromophore region show that the label stabilizes its attached helical residue. A study of Corey-Pauling-Koltun models and extant theories suggests that the induced CD arises by coupling of the carboxylate π-π* and the bound chromophore 1B1 elec. transition moments.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Ha, T. B. T.; Souchard, J. P.; Wimmer, F. L.; Johnson, N. P. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Safety of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

The coupling constants 3J(Pt-H) of Pt(Xpy)2Z2 and Pt(Xpy)(DMSO)I2 (Xpy = py and its 4-Me, 3,5-Me, 4-Cl, 4-CN, 4-HOCH2, 4-AcO derivatives; Z = Cl, I, Br, ONO2) were recorded. The 3J(Pt-H) values of the cis complexes are 42 ± 2 Hz, while those of the trans derivatives are 31.5 ± 2.5 Hz. 2J(Pt-H) of [Pt(XNH2)2Z2] (X = Me, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl; Z = Cl, I, ONO2) were recorded. The 2J(Pt-H) values of the cis complexes are 66.5 ± 1.5z, those of the trans derivatives are 58 ± 2 Hz. Measurements of Pt-H coupling constants is a rapid method of identifying the cis and the trans isomers of Pt(II) complexes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem