Tag: M.W:400-500

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Spectroscopy Letters called Spectral studies of some pyridine and bipyridine complexes of platinum(II), Author is Agarwala, Badri Vishal, the main research direction is platinum pyridine bipyridine spectra; UV platinum pyridine bipyridine; magnetic CD platinum pyridine bipyridine.Synthetic Route of C10H10Cl2N2Pt.

Electronic absorption spectra and magnetic CD (MCD) spectra were studied for the square planar complexes cis- and trans-Pt(py)2Cl2 and Pt(2,2′-bipyridine)Cl2(I). Detailed studies were carried out for I due to its fair solubility in many solvents and the solvent effect on its electronic spectra was investigated. The band assignments of the electronic spectra are discussed and are supported by the MCD spectra. NMR and magnetic studies were also carried out on the complexes to further elucidate their configuration. All the complexes studied are diamagnetic in conformity with their square planar arrangement.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Synthetic Route of C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Discovery of SY-5609: A Selective, Noncovalent Inhibitor of CDK7. Author is Marineau, Jason J.; Hamman, Kristin B.; Hu, Shanhu; Alnemy, Sydney; Mihalich, Janessa; Kabro, Anzhelika; Whitmore, Kenneth Matthew; Winter, Dana K.; Roy, Stephanie; Ciblat, Stephane; Ke, Nan; Savinainen, Anneli; Wilsily, Ashraf; Malojcic, Goran; Zahler, Robert; Schmidt, Darby; Bradley, Michael J.; Waters, Nigel J.; Chuaqui, Claudio.

CDK7 has emerged as an exciting target in oncol. due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. This report describes the discovery of SY-5609, a highly potent (sub-nM CDK7 Kd) and selective, orally available inhibitor of CDK7 that entered the clinic in 2020 (ClinicalTrials.gov Identifier: NCT04247126). Structure-based design was leveraged to obtain high selectivity (>4000-times the closest off target) and slow off-rate binding kinetics desirable for potent cellular activity. Finally, incorporation of a phosphine oxide as an atypical hydrogen bond acceptor helped provide the required potency and metabolic stability. The development candidate SY-5609 displays potent inhibition of CDK7 in cells and demonstrates strong efficacy in mouse xenograft models when dosed as low as 2 mg/kg.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Synthetic Route of C10H10Cl2N2Pt. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Microcalorimetric studies of the thermal decomposition of ammonia-halide and amine-halide complexes of platinum(II), [Pt(NH2R)2X2]. Author is Al Takhin, Ghassan; Skinner, Henry A.; Zaki, Ahmed A..

The standard heats of formation of the crystalline compounds [PtL2X2] [L = NH2R (R = H, Me, CHMe2, Bu, Et, Pr, CH2CHMe2), en, pyridine; X = Cl, Br, I] were derived from the enthalpies of thermal decomposition of their cis isomers at elevated temperatures The enthalpy of sublimation (ΔHsub) of [PtL2Cl2] (L = pyridine) is estimated as 170 kJ/mol, which gives an average pyridine-Pt bond-dissociation enthalpy of 122 kJ/mol in the gas phase. For other amine ligands, the bond-dissociation enthalpy is less than for the pyridine complex, falling to a min. of 97 kJ/mol for NH3. These imply sublimation heats of 270-300 kJ/mol in the Cl complexes.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interaction of cis platinum(II) compounds with poly(L-glutamate). A doubly anchored spin-label and a doubly anchored chromophore-label. Author is Chao, Yen Yau H.; Holtzer, Alfred; Mastin, Stephen H..

The free-radical 4-amino-2,2,6,6-tetramethylpiperidinyl-1-oxy [14691-88-4] yields cis-Pt(ATMPO)2(NO3)2 [64716-94-5], which is used to label poly(L-glutamate) (I), poly(L-aspartate) (II), and poly(L-lysine) (III). Labeling occurs by displacement of nitrate by polymer side chains. EPR spectra of oriented films of labeled I are strongly anisotropic; several arguments suggest that the major cause is g anisotropy. Spectra of solutions, in several solvents, of labeled I are also anisotropic and monitor the helix-coil transition and polymer aggregation. Since monofunctional, side-chain labels show only isotropic motions, Pt must be bifunctionally anchored to adjacent carboxylates, requiring the label to follow backbone segmental motions. With shorter side chains (II) adjacent double anchoring is impossible; with longer side chains (III), flexibility reduces coupling to backbone motion; in each, therefore, spectra are isotropic. Chromophoric compounds, particularly cis-Pt(bipy)(H2O)2][NO3]2 [64800-95-9], are similarly used. Bifunctional attachment is evidenced by the absence of base-induced UV spectral shifts (characteristic of attachment of OH- to Pt) shown by label alone, and by similarity of the spectra of labeled polymer and labeled oxalate. Induced CD appears for α helix in the region of the chromophore π-π* bands; transition to random coil drastically reduces this CD. With extensively labeled polymer differences in the course of the helix-coil transition as monitored by CD in the backbone region with that monitored in the chromophore region show that the label stabilizes its attached helical residue. A study of Corey-Pauling-Koltun models and extant theories suggests that the induced CD arises by coupling of the carboxylate π-π* and the bound chromophore 1B1 elec. transition moments.

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Tetrahydroisoquinoline – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Metathesis reactions between heavy D8 fluorides and I(III)-pyridine complexes.Related Products of 15227-42-6.

The reaction between trans-[AuF2(pyridine)2]+ and [PhI(pyridine)2]2+ results in the formation of PhIF2 and [Au(pyridine)4]3+. Investigation of the reaction pathway using model Pd and Pt analogs of the gold complex indicate the most likely mechanism is attack by the Au-F onto the I(III), rather than a redox process. This demonstrates that the Au(III)-F fragment can behave in a nucleophilic manner even in a relatively electron poor cationic complex.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Mutation Research called Prophage induction and mutagenicity of a series of antitumor platinum(II) and platinum(IV) coordination complexes, Author is Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Formula: C10H10Cl2N2Pt.

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Formula: C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Preparation and spectroscopic investigations of platinum complexes. I. Interpretation of the spectra of inverse electron transfer and ligand field transitions of platinum(II) complexes with halide and nitrogen ligands, the main research direction is platinum inverse charge transfer; halide pyridine platinum UV.Synthetic Route of C10H10Cl2N2Pt.

Inverse electron-transfer transitions of the type, 5d(Pt) → π(L), were detected in the electronic absorption spectra of cis- and trans-PtL2X2 complexes in which N-containing ligands have an internal π-electron system (L = pyridine, 3- or 4-chloropyridine, 3,5-dichloropyridine, 4-pentyl- or 4-cyanopyridine, or piperidine; X = Cl, Br, or I). In addition to ligand-field (d-d) and ligand π-π* transitions, 3 charge-transfer transitions were distinguished in the spectra of these complexes in CH2Cl2 or cyclohexane solutions Quant. correlation was established between energy of the ligand field transitions and energy of the inverse charge-transfer transitions.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Synthetic Route of C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Formula: C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal isomerization of complex platinum(II) compounds. Author is Kukushkin, Yu. N..

The thermal cis-trans isomerization of [PtA2I2] complexes, where A = NH3, MeNH2, EtNH2, pyridine, was studied by derivatography. The heat of isomerization is 1-7 kcal/mole. trans-[Pt(R2SO)ACl2]-type complexes melt upon heating and isomerize in the melt. The isomerization reaction proceeds through formation of a tetrahedral intermediate.

There is still a lot of research devoted to this compound(SMILES：[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2)Formula: C10H10Cl2N2Pt, and with the development of science, more effects of this compound(15227-42-6) can be discovered.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

SDS of cas: 15227-42-6. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Electrochemical reduction of geometric isomers of [Pt(C5H5N)2Cl2Br2] on a dropping mercury electrode in propylene carbonate solutions. Author is Vorob’ev-Desyatovskii, N. V.; Ravdel, B. A.; Ukraintsev, I. V..

The method of classical polarog. on a dropping Hg electrode in propylene carbonate was used to study the reduction of the isomeric complexes of Pt(IV) of type [Pt(C5H5N)2Cl2Br2] and of Pt(II) of type [Pt(C5H5N)2X2], where X = Cl, Br. The reduction of cis,cis,trans-[Pt(C5H5N)2Cl2Br2] and of cis,trans,cis-[Pt(C5H5N)2Cl2Br2] occurs according to an electrochem.-chem. mechanism during which, and following the 1-electron reduction of Pt(IV) to Pt(III), there occurs an intramol. redox process with participation of coordinated pyridine.

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Tetrahydroisoquinoline – Wikipedia,
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SDS of cas: 15227-42-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Unusual chemical behavior and molecular structure of a platinum(II) complex with N,N-diethylhydroxylamine. Author is Kuz’mina, L. G.; Porai-Koshits, M. A.; Vorob’ev-Desyatovskii, N. V..

cis-[PtL2Cl2] (L = Et2NOH) was prepared by the reaction of K2PtCl4 with L. cis-[PtL2Cl2] does not react with amines (NH3, pyridine, Et2NOH) and L does not react with cis-[PtA2Cl2] (A = NH3, py). cis-[PtL2Cl2] is monoclinic, space group C2, a 7.569(2), b 12.384(7), c 15.428(2) Å, β 100.00(2)°, Z = 4, R = 0.0287. One L coordinates to Pt through the N atom whereas the other is in the zwitterionic form and coordinates through the O atom. The low reactivity of cis-[PtL2Cl2] in substitution reactions is explained on the basis of H bonding and agostic interactions due to which the axial positions in the square planar complexes are blocked against nucleophilic attack.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem