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Kotowski, M.; Palmer, D. A.; Kelm, H. published the article 《Volumes of activation for the substitution reactions of cis- and trans-[PtL2(Cl)X] with pyridine in various solvents》. Keywords: platinum complex substitution kinetics pyridine; volume activation platinum complex substitution; solvent effect platinum complex substitution.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Computed Properties of C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The pressure dependence of the 2nd-order rate constant for the substitution of pyridine for Cl in trans-[Pt(py)2(Cl)(NO2)] was measured in the solvents nitromethane, methanol, ethanol, and dichloromethane. The resp. ΔV*exptl. values were calculated to be -6.2 ± 0.4 at 10°, -8.8 ± 0.6 at 25°, -13.1 ± 0.8 at 25°, and -19.8 ± 1.7 cm3 mol-1 att 25°. The ΔVexptl. values for the corresponding reactions of cis-[Pt(py)2(Cl)(NO2)] and trans-[Pt(PEt3)2Cl2] in methanol at 25° are -5.5 ± 0.5 and -13.6 ± 0.8 cm3 mol-1, resp. These ΔV*exptl.’s were found to be only slightly temperature dependent. The activation parameters ΔH*2 and ΔS*2 were also determined for each reaction. The volume change associated with the partial formation of the Pt-pyridine bond was estimated to be -4 ± 1 cm3 mol-1. A qual. explanation of the solvent dependence of ΔV*exptl. is also given.

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Recommanded Product: cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Interaction of pyridineplatinum(II) complexes with alkyl sulfoxides. Author is de Vekki, D. A..

The reaction of cis- and trans-[Pt(py)2Cl2] and [Pt(py)4]Cl2 with DMSO and Et2SO was studied by NMR. The products of the reaction are pyridine sulfoxide complexes and bis(sulfoxide) complexes. With heating cis/trans isomerization occurred, determining the configuration of the final products.

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Formula: C10H10Cl2N2Pt. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Antitumor activity of Group VIII transition metal complexes. I. Platinum(II) complexes. Author is Cleare, Michael J.; Hoeschele, James D..

A wide variety of Pt(II) complexes were studied for antitumor activity against Sarcoma 180 in female mice. In general only neutral complexes exhibited activity, whereas charged species were inactive and relatively nontoxic. A series of complexes of the type cis-[PtA2X2] (where A2 is either 2 monodentate or 1 bidentate amine ligand and X2 is either 2 monodentate or 1 bidentate anionic ligand) were studied with A and B being systematically varied. At least 10 potentially active antitumor drugs were identified, including cis-dichlorbis(methylamine)platinum(2+) [15273-32-2], diamminepropanedioatoplatinum(2+) [38780-43-7], and (1,2-ethanediammine-N,N’)(2-methylpropanedioato)platinum(2+) [41575-97-7]. The trans isomers were inactive in comparison with active cis complexes, so the presence of cis-reactive ligands seems to be a necessary parameter for antitumor activity. Complexes with highly reactive ligands such as cis-[Pt(NH3)2 (H2O)2](NO3)2 were highly toxic. Pd(II) complexes analogous to the active Pt(II) compounds were themselves inactive.

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Tetrahydroisoquinoline – Wikipedia,
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Computed Properties of C10H10Cl2N2Pt. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Binding of antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents. Author is Gale, Glen R.; Morris, Carl R.; Atkins, Loretta M.; Smith, Alayne B..

Tritiated cis-dichloro(dipyridine)platinum(II) (I) [15227-42-6] bound to intact Ehrlich ascites tumor cells at 37.deg. in vitro and remained associated with the acid-insoluble fraction of the cells. The extent of binding was also increased with increasing hydrogen ion [1333-74-0] concentration in the medium. The binding was enhanced markedly at 60.deg. and the maximum number of binding sites/cell was .sim.7 billion at this temperature Of 49 chems. and drugs tested, none decreased appreciably the rate and extent of binding, whereas certain heavy metals, and compounds that compromise membrane permeability enhanced the binding. Human and bovine lymphocytes had similar binding characteristics, but bound much more I/unit of cell volume.

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Tetrahydroisoquinoline – Wikipedia,
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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about cis-Bis(pyridine)platinum(II) organoamides with unexpected growth inhibition properties and antitumor activity.Category: tetrahydroisoquinoline.

The platinum(II) organoamides [Pt(NRCH2)2L2] (L = pyridine (py), R = p-HC6F4, C6F5, p-IC6F4, p-ClC6F4, p-C6F5C6F4; L = 4-methylpyridine, R = p-HC6F4) and [Pt(NRCH2CH2NR’)(py)2] (R = p-HC6F4, R’ = C6F5, p-BrC6F4, or p-MeC6F4) inhibit the growth of murine L1210 leukemia cells in culture with ID50 values for continuous exposure in the range 0.6-2.7 μM. Representative complexes are also active against L1210 cells in 2-h pulse exposures, as well as against the cisplatin-resistant variant L1210/DDP and human colonic carcinoma cell lines HT 29 and BE. Three complexes [Pt(NRCH2)2L2] (R = p-HC6F4, C6F5, or p-IC6F4) have good activity (T/C ≥ 180%) against P388 leukemia in mice, and all other compounds tested are active except when R = p-C6F5C6F4, L = py. Although the mol. basis of the biol. activity of these complexes is not known, the observation of good activity for amineplatinum(II) compounds with no hydrogen substituents on the nitrogen donor atoms introduces a new factor in the anticancer behavior of platinum(II) complexes.

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Tetrahydroisoquinoline – Wikipedia,
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Synthetic Route of C10H10Cl2N2Pt. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Redistribution of ligands in [Rh(CO)A(PPh3)2][Pt(py)Cl3].

[Rh(CO)A(PPh3)2][Pt(py)Cl3].DMF (I; A = py, 4-picoline (pic), 2,2′-bipyridine (bpy), 1,10-phenanthroline (phen)) were prepared by the reaction of [Rh(CO)A(PPh3)2]NO3 with K[Pt(py)Cl3] in DMF. For I (A = py, pic) at room temperature in DMF, Me2CO, CHCl3 or C6H6 after 15-30 min., redistribution of ligands occurred with the formation of Rh(CO)(PPh3)2Cl and cis-Pt(py)ACl2. I (A = bpy, phen) are stable in solution

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Name: cis-Dichlorobis(pyridine)platinum(II). The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Effect of catalyst structure on the reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane. Author is Vekki, D. A.; Skvortsov, N. K..

Reaction of α-methylstyrene with 1,1,3,3-tetramethyldisiloxane in the presence of the complexes of Pt(II), Pd(II) and Rh(I) is explored. In the presence of Pt catalyst, hydrosilylation of α-methylstyrene occurs predominantly giving β-adduct, while on Pd catalysts proceeds reduction of α-methylstyrene and on Rh catalysts both processes take place. In the reaction mixture proceeds disproportion and dehydro-condensation of 1,1,3,3-tetramethyldisiloxane that gives long chain linear and cyclic siloxanes HMe2Si(OSiMe2)nH and (-OSiMe2-)m (n = 2-6, m = 3-7), resp. Platinum catalysts promotes formation of linear siloxanes, while both Rh and Pd catalysts afford linear and cyclic siloxanes as well. Structure of intermediate metallo-complexes was studied.

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Tetrahydroisoquinoline – Wikipedia,
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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 882562-40-5, is researched, SMILESS is ClC1=NC(C2=CN(C3=C2C=CC=C3)S(=O)(=O)C2=CC=CC=C2)=C(Cl)C=N1, Molecular C18H11Cl2N3O2SJournal, Article, Journal of Medicinal Chemistry called Structure- and Reactivity-Based Development of Covalent Inhibitors of the Activating and Gatekeeper Mutant Forms of the Epidermal Growth Factor Receptor (EGFR), Author is Ward, Richard A.; Anderton, Mark J.; Ashton, Susan; Bethel, Paul A.; Box, Matthew; Butterworth, Sam; Colclough, Nicola; Chorley, Christopher G.; Chuaqui, Claudio; Cross, Darren A. E.; Dakin, Les A.; Debreczeni, Judit E.; Eberlein, Cath; Finlay, M. Raymond V.; Hill, George B.; Grist, Matthew; Klinowska, Teresa C. M.; Lane, Clare; Martin, Scott; Orme, Jonathon P.; Smith, Peter; Wang, Fengjiang; Waring, Michael J., the main research direction is EGFR activating gatekeeper mutant covalent inhibitor SAR.Synthetic Route of C18H11Cl2N3O2S.

A novel series of small-mol. inhibitors has been developed to target the double mutant form of the epidermal growth factor receptor (EGFR) tyrosine kinase, which is resistant to treatment with gefitinib and erlotinib. Our reported compounds also show selectivity over wild-type EGFR. Guided by mol. modeling, this series was evolved to target a cysteine residue in the ATP binding site via covalent bond formation and demonstrates high levels of activity in cellular models of the double mutant form of EGFR. In addition, these compounds show significant activity against the activating mutations, which gefitinib and erlotinib target and inhibition of which gives rise to their observed clin. efficacy. A glutathione (GSH)-based assay was used to measure thiol reactivity toward the electrophilic functionality of the inhibitor series, enabling both the identification of a suitable reactivity window for their potency and the development of a reactivity quant. structure-property relationship (QSPR) to support design.

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Tetrahydroisoquinoline – Wikipedia,
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Diab, Sarah; Yu, Mingfeng; Wang, Shudong published an article about the compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5,SMILESS:ClC1=NC(C2=CN(C3=C2C=CC=C3)S(=O)(=O)C2=CC=CC=C2)=C(Cl)C=N1 ).Related Products of 882562-40-5. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:882562-40-5) through the article.

A review. Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to reduced cell proliferation. Importantly, it is now agreed that targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without causing an outage of transcription of housekeeping genes. Thus, CDK7 has been considered as a viable therapeutic target in cancer. Indeed, the development of CDK7 inhibitors has gained huge momentum with two mols., CT7001 and SY-1365, currently under clin. development. Herein, we discuss the latest understanding of the role of CDK7 in cancer cells and provide an overview of the pharmacophores of CDK7 inhibitors, their efficacy in various cancer models, and their clin. development.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Safety of cis-Dichlorobis(pyridine)platinum(II). So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Suppression of growth by platinum(II) complexes in relation to their structure.

Structure-activity studies with 17 Pt-containing complexes showed a correlation between the ability of these complexes to inhibit cell division in corn roots and their known antitumor activities. For the more active compounds C90 (90% suppression of root growth rate) for 3 days was 3 × 10-6M, close to the corresponding amount for highly active inhibitors of other chem. classes. Possible use of the root growth rate to study the biol. activity of Pt-containing complexes is suggested. Structure-activity relations were discussed.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem