Tag: M.W:400-500

Sokolenko, V. A.; Bondarenko, V. S.; Korniets, E. D.; Kovtonyuk, N. P.; Kovrova, N. B. published the article 《Solid-phase condensation of coordinated pyridine and γ-picoline in platinum(II) complexes》. Keywords: thermolysis platinum picoline pyridine complex; condensation picoline pyridine coordinated platinum.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Electric Literature of C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The thermolysis of cis- and trans-[PtL2Cl2] (L = py, γ-picoline (pic)) was studied by IR and 1H NMR spectroscopy. cis-[PtL2Cl2] underwent cis-trans isomerization in the solid state at 200-220°. Thermolysis of trans-[PtL2Cl2] at 240-300° led to condensation of coordinated L to give PtL1Cl2 (L1 = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine). Thermolysis of [Pt(pic)4]Cl2 gave trans-Pt(pic)2Cl2 at 160°.

Here is just a brief introduction to this compound(15227-42-6)Electric Literature of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Reactivity of geometric isomers of (-)-dichloropyridine(methyl p-tolyl sulfoxide)platinum(II) by optical rotatory dispersion, the main research direction is platinum sulfoxide pyridine complex substitution nucleophile; isomerization platinum sulfoxide pyridine complex reaction nucleophile.SDS of cas: 15227-42-6.

The reactions of the optically active geometric isomers of (-)-[Pt(Me-p-TolSO)(Py)Cl2] with several nucleophilic reagents (py, Ph3PS, Ph3P, Ph3As, and Me2SO) were studied by ORD, IR spectroscopy, and 1H and 31P NMR spectroscopy. A mechanism for the reaction is proposed.

Here is just a brief introduction to this compound(15227-42-6)SDS of cas: 15227-42-6, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Electric Literature of C10H10Cl2N2Pt. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about The effect of complexation with platinum in polyfluorene derivatives: A photo- and electro-luminescence study. Author is Assaka, Andressa M.; Hu, Bin; Mays, Jimmy; Iamazaki, Eduardo T.; Atvars, Teresa D. Z.; Akcelrud, Leni.

The synthesis and characterization of a polymeric structure containing fluorene units statistically linked to 3-cyclohexyl-thiophene and bipyridine PFOTBipy-poly[(4-hexylthiophene-2,5-diyl)(9,9-dihexyl-fluoren-2,7-diyl)-co-(bipyridine-5.5′-diyl)(9,9-dihexyl-fluoren-2,7-diyl)], is reported. The complexation with platinum was possible through the bipyridil units present in 10%, 50% and 100% content. The structure has a fluorenyl moiety between each bipyridine and thiophene groups resulting in a stable and efficient light-emitting polymeric material combining the well known emissive properties of fluorene, the charge mobility generated by thiophene and the electron-transfer properties of a metal complex as well. All the polymers were photo and electroluminescent materials, and showed phosphorescence at low temperatures Photoluminescence properties were studied by steady state and time resolved spectroscopy and showed changes of both emission peak and relative intensity of the emission bands depending on the relative amount of the platinum complex. The electroluminescence followed the trends found for photoluminescence. The blue emission of the copolymer without platinum is due to the fluorenyl segments and for higher complex contents the emission is characteristic of the aggregates involving the bipyridinyl moieties. Therefore, emission color can be tuned by the complex content. The turn-on voltage was strongly reduced from 22 to 8 V for the 100% complexed copolymer, as compared to the device made with the non complexed one, but the luminance decreased, due to quenching or trapping effects.

Here is just a brief introduction to this compound(15227-42-6)Electric Literature of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Spectral and structural properties of the crystalline complex dichlorodi(pyridine)palladium, the main research direction is IR Raman palladium pyridine chloride.Related Products of 15227-42-6.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

Here is just a brief introduction to this compound(15227-42-6)Related Products of 15227-42-6, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ) is researched.Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II).Mattern, I. E.; Cocchiarella, L.; Van Kralingen, C. G.; Lohman, P. H. M. published the article 《Prophage induction and mutagenicity of a series of antitumor platinum(II) and platinum(IV) coordination complexes》 about this compound( cas:15227-42-6 ) in Mutation Research. Keywords: antitumor platinum compound mutagenesis; prophage induction antitumor platinum compound. Let’s learn more about this compound (cas:15227-42-6).

Eleven Pt compounds with N donor ligands (aminocyclopentane, aminocyclohexane, pyridine, etc.), previously tested for antitumor activity, were studied for induction of prophage λ and for mutagenicity in the Ames assay, with various strains of Salmonella. The compounds included cis and trans isomers of Pt(II) and Pt(IV) complexes and were tested with and without metabolic activation. All the cis compounds elicited prophage induction, whereas the trans compounds were inactive. Mutagenicity was found only in strains containing the R factor, indicating that SOS-type repair processes are required for the conversion of initial DNA lesions into mutations. Mutation induction was also influenced by the excision-repair process. The 2 trans compounds were not, or only slightly, mutagenic; all other compounds were mutagenic in at least one strain, exhibited a 2-20-fold increase over the spontaneous background level. Addition of liver homogenate had no significant effect on the number of mutants. One compound induced exclusively frameshift mutations. The other mutagenic compounds induced frameshift mutations as well as base-pair substitutions. Seven compounds were more mutagenic for the repair-proficient than for the repair-deficient strains; only one showed the opposite effect. Apparently, for mutagenicity testing of Pt compounds, repair-proficient strains are more sensitive indicators. The differences in response of the various strains toward the compounds suggest the formation of different DNA lesions and(or) a selective action of repair processes on these lesions. In general, a good qual. correlation was observed between prophage-inducing capacity, mutagenicity in bacterial and mammalian cells and antitumor activity.

Here is just a brief introduction to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhurnal Neorganicheskoi Khimii called Cis-bis(pyridine)dichloro derivatives of platinum(IV), Author is Chernyaev, I. I.; Zheligovskaya, N. N.; Bavina, T. V., which mentions a compound: 15227-42-6, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2Pt, Reference of cis-Dichlorobis(pyridine)platinum(II).

The complexes Pt(py)2Cl2XNO2 (X = Cl-, Br-) and Pt(py)2Cl2(OH)NO2 were precipitated by adding 5-10 ml. H2O to mixtures of equivalent amounts of Pt(py)2Cl2(NO2)NO3 (I) and KCl, KBr, or KOH, resp. I reacts with KI to give a mixture of Pt(py)2Cl2I2 and Pt(py)2Cl2INO2. Chlorination of Pt(py)2Cl2 yields [Pt(py)2Cl2]Cl2. [Pt(py)2Cl2][Pt(py)2Cl2(OH)2] was obtained from Pt(py)2Cl2 and 10% aqueous H2O2 at room temperature after standing for 24 hrs. Individual species were identified by x-ray diffraction tests. The aqueous solutions of Pt(py)2Cl2XNO2 undergo hydrolysis according to: Pt(py)2Cl2XNO2 + H2O ⇌ [Pt(py)2Cl2X(H2O)]+ + NO2-, whereas the aqueous solutions of Pt(py)2Cl2(OH)2 and [Pt(py)2Cl2]Cl2 are considerably more stable. Solutions of Pt(py)2Cl2Br2 partially decompose in light to Pt(py)2Cl2, HBrO, and HBr, resp.

Here is just a brief introduction to this compound(15227-42-6)Reference of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Experimental criteria for the applicability of the group model to stretching vibrations of the dichloroplatinum fragment in square planar complexes. Author is Konovalov, L. V.; Pogareva, V. G.; Stanevich, A. E.; Fomina, T. N..

A correlation was found between the Pt-Cl bond length difference, Δr, and the distance, Δν, between the doublet components of the stretching vibration νClPt in cis[PtCl2LL’] complexes with 2 different ligands, L and L’. For Δr = 0-0.025 Å, a constant splitting Δν = 15-25 cm-1 was observed, but for Δr >0.03 Å Δν increased linearly with increasing Δr. The difference was explained in terms of sym. and asym. Pt-Cl bonds.

Here is just a brief introduction to this compound(15227-42-6)Application In Synthesis of cis-Dichlorobis(pyridine)platinum(II), more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Far infrared spectra of palladium compounds. II. Pyridine and 2,2′-bipyridyl complexes of palladium(II) and platinum(II), the main research direction is PALLADIUM COMPLEX IR SPECTRA; IR SPECTRA PD COMPLEX; PLATINUM COMPLEX; PYRIDINE COMPLEX; BIPYRIDYL COMPLEX.Computed Properties of C10H10Cl2N2Pt.

The IR spectra of several sq. planar cis and trans Pd(II) and Pt(II) pyridine complexes of the type M(py)2X2 (where X = Cl, Br, and I) have been recorded from 2000 to 50 cm.-1 Comparison of the spectra of complexed pyridine to that of the free base shows 9 normal vibrations have shifted to higher frequencies on the order of 15 to 80 wave numbers The shifts are attributed to changes in the electron d. over the pyridine ring. Only insignificant shifts in a few of the normal modes of the complexed pyridine were observed between the corresponding cis and trans isomers. The assignment of the M-X stretching and bending vibrations as well as possible assignments for the M-N stretching vibrations are given and discussed. The IR spectra of Pd(II)-2,2-bipyridyl (bipy) complexes of the type Pd(bipy)2X2 (where X = Cl, Br, and I) were also recorded from 2000 to 50 cm.-1 Comparison of the spectra to those of the pyridine complexes and the free bipyridine is made. 18 references.

Here is just a brief introduction to this compound(15227-42-6)Computed Properties of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 15227-42-6, is researched, SMILESS is [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2, Molecular C10H10Cl2N2PtJournal, Journal of Luminescence called Luminescence properties of some platinum(II) complexes. Counter-ion and molecular geometry effects, Author is Diomedi Camassei, F.; Ancarani-Rossiello, L.; Castelli, F., the main research direction is reflection platinum complex structure; luminescence platinum complex structure; phosphorescence platinum complex structure; counter ion platinum complex.Electric Literature of C10H10Cl2N2Pt.

Reflectance and luminescence spectra, and emission lifetimes of 14 charged and neutral Pt(II) crystalline complexes are reported. The lifetimes (in the range of some tens of μsec) indicate that the emissions are due to a spin-forbidden process. On the basis of spectral correlations, the phosphorescence is tentatively identified as due to the lowest d-d ligand field transition when the bonding of the ligand is essentially σ in character, and to a π* → d charge-transfer transition for those complexes in which the ligands themselves have π orbital systems. Both the radiative (kr) and nonradiative (kn) rate constants are sensitive to changes in mol. geometry (cis,trans isomers) and counter-ions. By assuming unitary efficiency for the intersystem crossing to the emitting state, the counter-ion appears to predominantly affect kn through vibrational coupling of the chromophore with the lattice. For the cis forms, both kr and kn are affected in a complex manner, with metal-metal interactions playing an important role. For the trans forms, however, the constancy of the quantum yield with respect to temperature suggests that kn is negligible in comparison to kr, and therefore the trans chromophores behave as isolated systems within the crystalline lattice.

Here is just a brief introduction to this compound(15227-42-6)Electric Literature of C10H10Cl2N2Pt, more information about the compound(cis-Dichlorobis(pyridine)platinum(II)) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5 ) is researched.Safety of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole.Diab, Sarah; Yu, Mingfeng; Wang, Shudong published the article 《CDK7 Inhibitors in Cancer Therapy: The Sweet Smell of Success?》 about this compound( cas:882562-40-5 ) in Journal of Medicinal Chemistry. Keywords: review pharmacophore CT7001 SY1365 antitumor CDK7 cancer. Let’s learn more about this compound (cas:882562-40-5).

A review. Cyclin-dependent kinase (CDK) 7 has a unique functional repertoire by virtue of its dual role in transcription and cell cycle progression. Whereas CDK7 is ubiquitously expressed in various types of cancer, its downregulation leads to reduced cell proliferation. Importantly, it is now agreed that targeting transcription selectively limits the synthesis of mRNAs involved in tumor growth without causing an outage of transcription of housekeeping genes. Thus, CDK7 has been considered as a viable therapeutic target in cancer. Indeed, the development of CDK7 inhibitors has gained huge momentum with two mols., CT7001 and SY-1365, currently under clin. development. Herein, we discuss the latest understanding of the role of CDK7 in cancer cells and provide an overview of the pharmacophores of CDK7 inhibitors, their efficacy in various cancer models, and their clin. development.

Here is just a brief introduction to this compound(882562-40-5)Safety of 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, more information about the compound(3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole) is in the article, you can click the link below.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem