Tag: M.W:400-500

Griffith, Darren; Bergamo, Alberta; Pin, Sara; Vadori, Marta; Mueller-Bunz, Helge; Sava, Gianni; Marmion, Celine J. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Safety of cis-Dichlorobis(pyridine)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

We describe the synthesis and characterization of a novel class of PtII and PtIV pyridine-hydroxamic acid (pyhaH) complexes of general formula cis-[PtIICl2(x-pyhaH)2] and cis-[PtIVCl4(x-pyhaH)2], resp., (where x = 3 or 4) in which the pyridine-hydroxamic acid is coordinated to the platinum ion via the pyridine nitrogen only leaving the hydroxamic acid free to potentially release cytotoxic nitric oxide (NO). The crystal structure of the PtIV derivative, cis-[PtCl4(4-pyhaH)2]·2CH3OH is reported. To establish the biol. effect of the uncoordinated hydroxamic acid moiety in the PtII compounds, the corresponding pyridinecarboxylic acid (pycaH) complexes of general formula cis-[PtIICl2(x-pycaH)2] (where x = 3 or 4) and the PtII pyridine (py) complex cis-[PtIICl2(py)2] were synthesized and served as reference standards The NO-releasing properties of each of the PtII compounds, the pyhaH and the pycaH ligands were studied. The PtII pyridine-hydroxamic acid derivatives were found to induce potent in vitro effects attributable to either NO-release from the hydroxamic acid moiety and/or stimulation of inducible nitric oxide synthase of endothelial cells.

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Tetrahydroisoquinoline – Wikipedia,
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HPLC of Formula: 15227-42-6. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Electrochemical reduction of geometric isomers of [Pt(C5H5N)2Cl2Br2] on a dropping mercury electrode in propylene carbonate solutions. Author is Vorob’ev-Desyatovskii, N. V.; Ravdel, B. A.; Ukraintsev, I. V..

The method of classical polarog. on a dropping Hg electrode in propylene carbonate was used to study the reduction of the isomeric complexes of Pt(IV) of type [Pt(C5H5N)2Cl2Br2] and of Pt(II) of type [Pt(C5H5N)2X2], where X = Cl, Br. The reduction of cis,cis,trans-[Pt(C5H5N)2Cl2Br2] and of cis,trans,cis-[Pt(C5H5N)2Cl2Br2] occurs according to an electrochem.-chem. mechanism during which, and following the 1-electron reduction of Pt(IV) to Pt(III), there occurs an intramol. redox process with participation of coordinated pyridine.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Volumes of activation for the substitution reactions of cis- and trans-[PtL2(Cl)X] with pyridine in various solvents.Product Details of 15227-42-6.

The pressure dependence of the 2nd-order rate constant for the substitution of pyridine for Cl in trans-[Pt(py)2(Cl)(NO2)] was measured in the solvents nitromethane, methanol, ethanol, and dichloromethane. The resp. ΔV*exptl. values were calculated to be -6.2 ± 0.4 at 10°, -8.8 ± 0.6 at 25°, -13.1 ± 0.8 at 25°, and -19.8 ± 1.7 cm3 mol-1 att 25°. The ΔVexptl. values for the corresponding reactions of cis-[Pt(py)2(Cl)(NO2)] and trans-[Pt(PEt3)2Cl2] in methanol at 25° are -5.5 ± 0.5 and -13.6 ± 0.8 cm3 mol-1, resp. These ΔV*exptl.’s were found to be only slightly temperature dependent. The activation parameters ΔH*2 and ΔS*2 were also determined for each reaction. The volume change associated with the partial formation of the Pt-pyridine bond was estimated to be -4 ± 1 cm3 mol-1. A qual. explanation of the solvent dependence of ΔV*exptl. is also given.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action, the main research direction is trans platinum antitumor complex resistance structure.Recommanded Product: cis-Dichlorobis(pyridine)platinum(II).

The cytotoxicity of transplatinum complexes of structural formula trans-[PtCl2(L)L’)] {L = L’ = pyridine or thiazole, or L = quinoline (R’ = methyl; R” = Me, Ph or CH2phenyl) and L’ = R’R”SO] has been studied in murine L1210 and human tumor cell lines. The results confirm previous observations that use of a sterically hindered planar ligand greatly enhances cytotoxicity, in comparison to trans-[PtCl2(NH3)2], such that in some cases cytotoxicity equivalent to that of the clin. used agent cisplatin [cis-{PtCl2(NH3)2]] is obtained. Results from both the panel of human ovarian carcinoma cell lines and the National Cancer Institute screening panel confirm a different pattern of cytotoxicity, with respect to cisplatin. The new trans-platinum complexes are also non-cross-resistant with cisplatin in both murine and human (human ovarian carcinoma panel) tumor cell lines. Preliminary mechanistic studies using both cis- and trans-[PtCl2(pyridine)2] in L1210 cells have been carried out, to delineate the reasons for both the dramatically enhanced cytotoxicity and the lack of cross-resistance with the clin. used agents. Intracellular uptake is enhanced for pyridine relative to ammine (NH3) complexes. The pyridine complexes also inhibit DNA synthesis, implying a role for DNA binding in their mechanism of action. Binding of the pyridine complexes to calf thymus DNA is, however, significantly less than for the analogous ammine complexes. The presence of trans-pyridine ligands results in steric hindrance, which retards the rate of reaction of trans-[PtCl2(pyridine)2], relative to trans[PtCl2(NH3)2], with other important biomols. such as glutathione. The results point to a potential new class of platinum antitumor complexes acting by a new mechanism and with activity complementary to agents such as cisplatin.

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Tetrahydroisoquinoline – Wikipedia,
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HPLC of Formula: 15227-42-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal migration of amines in platinum(II) complexes. Author is Kukushkin, Yu. N.; Sedova, G. N.; Belyaev, A. N..

Derivatog. data indicate that the 1st stage of the thermal conversion of (LH)2[PtCl4] (L = NH3, MeNH2, piperidine, pyridine, γ-picoline, PhNH2, p-toluidine, 8-hydroxyquinoline, quinoline) or (enH2)[PtCl4] is the cleavage of HCl and the formation of PtL2Cl2. All the complexes studied fall into 2 groups according to the temperature of the beginning of the process: (1) complexes with a temperature for the start of thermal reaction at 180 – 200° contain amines the basicity constants of which are >10-5 and (2) complexes with decomposition temperatures at 130-50° contain amines the basicity constants of which are <10-8. If you want to learn more about this compound(cis-Dichlorobis(pyridine)platinum(II))HPLC of Formula: 15227-42-6, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(15227-42-6).

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Tetrahydroisoquinoline – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Adducts of coordination compounds – 12. New hydrogen dinitrates and their structures》. Authors are Al-Zamil, Nabila S.; Evans, E. H. M.; Gillard, R. D.; James, David W.; Jenkins, Tudor E.; Lancashire, Robert J.; Williams, P. A..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Category: tetrahydroisoquinoline. Through the article, more information about this compound (cas:15227-42-6) is conveyed.

The new compounds trans-[Ru(py)4Cl2][H(ONO2)2] and [C13H9NH][H(ONO2)2] were characterized (C13H9N = phenanthridine) and these, with the known compounds trans-[Ir(py)4Cl2][H(ONO2)2], C13H9N.2HNO3.2H2O and [phenH][H(ONO2)2] (phen = 1,10-phenanthroline) shown to involve the H dinitrate ion. The crystal and mol. structure of the Ru complex was determined The orthorhombic unit cell, space group Pbcn has a 7.54, b 21.83, c 14.86 (±0.01) Å, Z = 4. The compound is isomorphous with the analogous Rh(III) complex, but has addnl. disorder involving the nitrate groups owing to loss of HNO3 with time to yield an isostructural mononitrate compound trans-[Ru(py)4Cl2][H(ONO2)2] and trans-[Pt(py)4Cl2](NO3)2 were obtained under conditions previously described as giving rise to nitration of the pyridine ring. In fact, no evidence for the formation of 3-nitropyridine was found during these studies.

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Tetrahydroisoquinoline – Wikipedia,
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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Supramolecular Nanoencapsulation as a Tool: Solubilization of the Anticancer Drug trans-Dichloro(dipyridine)platinum(II) by Complexation with β-Cyclodextrin, published in 2008-04-30, which mentions a compound: 15227-42-6, mainly applied to beta cyclodextrin trans dichlorodipyridine platinum complex nanoencapsulation solubilization anticancer, Quality Control of cis-Dichlorobis(pyridine)platinum(II).

A novel, water-soluble trans-platinum complex was synthesized by inclusion complexation with β-cyclodextrin. The complexation was confirmed by 1H NMR, FT-IR, TGA, and XRD as well as by SEM and EDX. As the precursor complex is not water-soluble, it is difficult to employ it for biol. applications. Here, we report that the encapsulation with cyclodextrin allowed to solubilize the complex to a solubility value of 1.6 mg/mL. Moreover, the cytotoxicity in vitro of the novel inclusion complex indicated a much higher activity after encapsulation.

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Tetrahydroisoquinoline – Wikipedia,
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HPLC of Formula: 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Density functional theory and surface enhanced Raman spectroscopy characterization of novel platinum drugs. Author is Giese, Bernd; Deacon, Glen B.; Kuduk-Jaworska, Janina; McNaughton, Don.

There is considerable interest in the development of novel platinum-based anticancer drugs that overcome the disadvantages associated with the widely used drug cisplatin, which are its inactivity against some types of tumors and its toxic side effects. In this study we show the suitability of normal Raman spectroscopy (NRS) and surface enhanced Raman spectroscopy (SERS), assisted by d. functional theor. (DFT) calculations, for the characterization of Pt complexes. The Pt complexes studied include the established drugs cisplatin and carboplatin, as well as five novel Pt complexes with anticancer activity. DFT calculations at the B3LYP/LanL2DZ level are a good prediction of the exptl. NRS spectra of small and medium sized Pt complexes. The use of SERS allows the investigation of Pt complexes at physiol. concentrations, and the binding strengths of the different ligands can be determined The formation of pos. charged hydrolysis products may be necessary for SERS activity. The existing group in the hydrolysis reaction can be identified.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Bis(pentafluorophenyl) complexes of palladium(II) and of platinum(II), published in 1974, which mentions a compound: 15227-42-6, Name is cis-Dichlorobis(pyridine)platinum(II), Molecular C10H10Cl2N2Pt, Synthetic Route of C10H10Cl2N2Pt.

The preparation of 8 bis(pentafluorophenyl) complexes of Pd(II) and of Pt(II) with monodentate and bidentate N-donor ligands is described together with a preparation of a Pd(II) complex of 1,2-bis(diphenylphosphino)ethane. Assignments of cis or trans configuration are discussed which depend upon the splitting or disappearance of certain bands in ir.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Al-Zamil, Nabila S.; Evans, E. H. M.; Gillard, R. D.; James, David W.; Jenkins, Tudor E.; Lancashire, Robert J.; Williams, P. A. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Product Details of 15227-42-6.They published the article 《Adducts of coordination compounds – 12. New hydrogen dinitrates and their structures》 about this compound( cas:15227-42-6 ) in Polyhedron. Keywords: hydrogen dinitrate preparation structure; ruthenium cationic complex hydrogen dinitrate; phenanthridinium hydrogen dinitrate; phenanthrolinium hydrogen dinitrate; iridium cation complex hydrogen dinitrate; crystal structure hydrogen dinitrate; structure ruthenium complex hydrogen dinitrate. We’ll tell you more about this compound (cas:15227-42-6).

The new compounds trans-[Ru(py)4Cl2][H(ONO2)2] and [C13H9NH][H(ONO2)2] were characterized (C13H9N = phenanthridine) and these, with the known compounds trans-[Ir(py)4Cl2][H(ONO2)2], C13H9N.2HNO3.2H2O and [phenH][H(ONO2)2] (phen = 1,10-phenanthroline) shown to involve the H dinitrate ion. The crystal and mol. structure of the Ru complex was determined The orthorhombic unit cell, space group Pbcn has a 7.54, b 21.83, c 14.86 (±0.01) Å, Z = 4. The compound is isomorphous with the analogous Rh(III) complex, but has addnl. disorder involving the nitrate groups owing to loss of HNO3 with time to yield an isostructural mononitrate compound trans-[Ru(py)4Cl2][H(ONO2)2] and trans-[Pt(py)4Cl2](NO3)2 were obtained under conditions previously described as giving rise to nitration of the pyridine ring. In fact, no evidence for the formation of 3-nitropyridine was found during these studies.

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Tetrahydroisoquinoline – Wikipedia,
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