Tag: M.W:400-500

Application of 15227-42-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Thermal decomposition of pyridine complexes of platinum (II). Author is Kukushkin, Yu. N.; Postnikova, E. S..

Thermal anal. of the decomposition of [Pt(py)4]Cl2.3H2O shows that in the initial stage of the reaction there is a joint loss of 2 mols. of pyridine and the H2O of crystallization As a result, trans-[Pt(py)2Cl2] is obtained. The cis-form is somewhat less thermally stable than the trans form. Upon thermal treatment of [Pt(py)4][PtCl4] at 195°, a mixture of geometric isomers of [Pt(py)2Cl2] is obtained.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Research at ICI Central Petrochemical and Polymer Laboratory, Runcorn Heath. NQR spectrometry.Computed Properties of C10H10Cl2N2Pt.

The use of 35Cl nuclear quadrupole resonance (NQR) in the study of transition metal compounds is discussed. In the NQR spectra of cis-and trans-L2PtCl2, the difference in the 35Cl NQR frequencies (νtrans-νcis) increases 0.95, 1.98, 3.1 MHz, for L = Me2NH, pyridine, and Bu3P, resp. Frequency variation is greater among the trans compounds Charge donating properties of L to Pt have a larger effect on the ν 35 Cl attached to the Pt than does the weakening influence of L. The 35Clν for bridging Cl in trans-L2Pt2Cl4 and trans-L2Pd2Cl4 are much lower (at 15.46 and 12.84 MHz, resp.) than the frequencies of the terminal Cl(at 22.36 and 19.56 MHz). This difference can be used in studying cluster compounds

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: cis-Dichlorobis(pyridine)platinum(II)(SMILESS: [Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2,cas:15227-42-6) is researched.Computed Properties of C10H10Cl2N2Pt. The article 《Suppression of growth by platinum(II) complexes in relation to their structure》 in relation to this compound, is published in Doklady Akademii Nauk SSSR. Let’s take a look at the latest research on this compound (cas:15227-42-6).

Structure-activity studies with 17 Pt-containing complexes showed a correlation between the ability of these complexes to inhibit cell division in corn roots and their known antitumor activities. For the more active compounds C90 (90% suppression of root growth rate) for 3 days was 3 × 10-6M, close to the corresponding amount for highly active inhibitors of other chem. classes. Possible use of the root growth rate to study the biol. activity of Pt-containing complexes is suggested. Structure-activity relations were discussed.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Martin, Marilyn; Krogh-Jespersen, Mary Beth; Hsu, Martha; Tewksbury, John; Laurent, Michel; Viswanath, Kasi; Patterson, Howard published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Recommanded Product: 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

Luminescence, absorption, and magnetic CD (MCD) experiments are reported for cis- and trans-dichlorobis(pyridine)platinum(II). For the trans isomer, an anal. of the temperature dependence of the lifetimes and luminescence intensities indicates that emission at 605 nm is from 2 excited π* states separated by 240 cm-1. For the cis isomer, time-resolved spectroscopy allowed observation of 2 emission bands at 600 and 700 nm, which were assigned from their lifetimes to π* → d and d → d transitions, resp. Further, temperature dependent lifetime studies show that the 600-nm band (π* → d) is from 2 electronic states separated by 200 cm-1. The absorption spectra of both isomers were measured at room and low temperatures in solution, in glasses, and in KCl pellets. From a comparison with the pyridine and Pt(NH3)2Cl2 absorption and MCD spectra and MO calculations, the observed absorption bands for Pt(py)2Cl2 are assigned as d → d, d → π*, and n, π → π* transitions. For the cis isomer the lowest unoccupied mol. orbital is a d metal orbital.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Category: tetrahydroisoquinoline. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole, is researched, Molecular C18H11Cl2N3O2S, CAS is 882562-40-5, about Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Author is Jiang, Baishan; Jiang, Jie; Kaltheuner, Ines H.; Iniguez, Amanda Balboni; Anand, Kanchan; Ferguson, Fleur M.; Ficarro, Scott B.; Seong, Bo Kyung Alex; Greifenberg, Ann Katrin; Dust, Sofia; Kwiatkowski, Nicholas P.; Marto, Jarrod A.; Stegmaier, Kimberly; Zhang, Tinghu; Geyer, Matthias; Gray, Nathanael S..

Development of inhibitors targeting CDK12/13 is of increasing interest as a potential therapy for cancers as these compounds inhibit transcription of DNA damage response (DDR) genes. We previously described THZ531, a covalent inhibitor with selectivity for CDK12/13. In order to elucidate structure-activity relationship (SAR), we have undertaken a medicinal chem. campaign and established a focused library of THZ531 analogs. Among these analogs, BSJ-01-175 demonstrates exquisite selectivity, potent inhibition of RNA polymerase II phosphorylation, and downregulation of CDK12-targeted genes in cancer cells. A 3.0 Å co-crystal structure with CDK12/CycK provides a structural rational for selective targeting of Cys1039 located in a C-terminal extension from the kinase domain. With moderate pharmacokinetic properties, BSJ-01-175 exhibits efficacy against an Ewing sarcoma tumor growth in a patient-derived xenograft (PDX) mouse model following 10 mg/kg once a day, i.p. administration. Taken together, BSJ-01-175 represents the first selective CDK12/13 covalent inhibitor with in vivo efficacy reported to date.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem