Although many compounds look similar to this compound(15227-42-6)SDS of cas: 15227-42-6, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Activation of the trans geometry in platinum antitumor complexes. Synthesis, characterization, and biological activity of complexes with the planar ligands pyridine, N-methylimidazole, thiazole, and quinoline. Crystal and molecular structure of trans-dichlorobis(thiazole)platinum(II), published in 1992-02-19, which mentions a compound: 15227-42-6, mainly applied to antitumor platinum chloro nitrogen donor complex; crystal structure platinum chloro thiazole complex, SDS of cas: 15227-42-6.
The presence of planar ligands in trans-[PtCl2(py)2] greatly enhances the cytotoxicity of such species, with respect both to their corresponding cis isomer and also to trans-[PtCl2(NH3)2]. The cytotoxicity of trans-[PtCl2(py)2] in murine tumor cell lines is equivalent to the anticancer drug cisplatin, cis-[PtCl2(NH3)2]. The generality of this effect was studied for a range of structures with planar ligands of formula trans-[PtCl2(L)(L’)]. Three distinct series were examined-(1) L = L’ = py, N-methylimidazole (N-MeIm), and thiazole (Tz), (2) L = quinoline (quin), L’ = MeRSO where (R = Me, CH2Ph, Ph), and (3) L = quinoline, L’ = NH3. The synthesis and chem. characterization of all new complexes are described. An x-ray crystal structure determination for trans-[PtCl2(Tz)2] confirmed the geometry with N-bound thiazole. The crystals are monoclinic, space group C2/c, a 8.088(3), b 14.964(4), c 8.847(2) Å, β 99.50(2), Z = 4, R = 0.0545, Rw = 0.0655. Pt has the expected square planar coordination with l(Pt-Cl) = 2.300(5) Å and l(Pt-N) = 2.024(18) and 2.077(17) Å. Bond angles are normal with N(1)-Pt-N(2) = 180.0(1)°, N(1)-Pt-Cl(1) = 90.4(1)°, and N(2)-Pt-Cl(1A) = 89.6(1)°. The intensity data were collected with MoKα radiation with λ = 0.71073 Å. The thiazole rings are not coplanar but slightly tilted to each other at an angle of 14.3°. The dihedral angles between the Pt coordination plane and the thiazole rings are 119.3 and 105.0°. The biol. studies confirm the generality of activation of the trans geometry using planar ligands. Cytotoxicity tests in murine leukemia (L1210) cell lines both sensitive and rendered resistant to cisplatin show that the complexes show equivalent cytostatic activity to that of cisplatin. The activity is an order of magnitude greater than trans-[PtCl2(NH3)2]. The cytotoxicity is further marked by consistent activity in the cisplatin-resistant cell line. Contrary to the well-established but empirical structure-activity relationships, the trans geometry can give platinum complexes with cytotoxicity equivalent to that of the analogous cis isomer. The results point to a further source of platinum antitumor complexes acting by a different mol. mechanism to cisplatin with potential for antitumor activity complementary to that of the clin. used drug.
Although many compounds look similar to this compound(15227-42-6)SDS of cas: 15227-42-6, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem