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Colamarino, Paolo; Orioli, Pier L. published the article 《Crystal and molecular structures of cis- and trans-dichlorobis(pyridine)platinum(II)》. Keywords: crystal structure platinum complex; pyridine platinum complex structure.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

The crystal and mol. structures of cis- and trans-dichlorobis(pyridine)platinum (I, II resp.) were determined from x-ray diffractometer data by heavy-atom techniques and refined by least squares to R 0.041 and 0.068 for 1000 and 1032 observed intensities for I and II, resp. Crystals of I are monoclinic, space group C2/c, with a 9.408, b 17.110, c 15.270 Å, β 98.53.degree., and Z = 8. Crystals of II are triclinic, space group P1̅, with a 7.695, b 7.091, c 5.542 Å, α 87.6, β 83.7, γ 79.3.degree., and Z = 1. Both complexes consist of discrete mols. with Pt in square planar coordination.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Experimental criteria for the applicability of the group model to stretching vibrations of the dichloroplatinum fragment in square planar complexes, the main research direction is vibration chloroplatinum complex bond length.Product Details of 15227-42-6.

A correlation was found between the Pt-Cl bond length difference, Δr, and the distance, Δν, between the doublet components of the stretching vibration νClPt in cis[PtCl2LL’] complexes with 2 different ligands, L and L’. For Δr = 0-0.025 Å, a constant splitting Δν = 15-25 cm-1 was observed, but for Δr >0.03 Å Δν increased linearly with increasing Δr. The difference was explained in terms of sym. and asym. Pt-Cl bonds.

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Tetrahydroisoquinoline – Wikipedia,
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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tessier, C.; Rochon, F. D. researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).Application of 15227-42-6.They published the article 《Multinuclear NMR study and crystal structures of complexes of the types cis- and trans-Pt(Ypy)2X2, where Ypy = pyridine derivative and X = Cl and I》 about this compound( cas:15227-42-6 ) in Inorganica Chimica Acta. Keywords: crystal structure platinum picoline pyridine halo; platinum pyridine picoline lutidine halo preparation structure; isomerization cis trans platinum pyridine halo; NMR platinum 195 pyridine halo complex; trans effect platinum pyridine halo complex. We’ll tell you more about this compound (cas:15227-42-6).

Cis- and trans-Pt(Ypy)2X2, where Ypy is a Me derivative of pyridine and X = Cl or I, were studied by spectroscopic methods, especially by multinuclear NMR spectroscopy. In 195Pt NMR, the cis-dichloro compounds were observed between -1998 and -2021 ppm in CDCl3, while the trans compounds were found at slightly lower field, between -1948 and -1973 ppm. The diiodo species were observed at much higher field, between -3199 and -3288 ppm for the cis isomers and between -3122 and -3264 ppm for the trans isomers. In 1H NMR, the 3J(195Pt-1H) coupling constants are larger for the cis compounds (∼42 ppm) than for the trans isomers (∼33 ppm). In 13C NMR, the values of 3J(195Pt-13C) also are larger for the cis complexes. There seems to be a slight dependence of the pKa values of the protonated ligands on the δ(Pt) chem. shifts. The presence of π-bonding between Pt and the pyridine ligands do not seem very important. The crystal structures of three dichloro and five diiodo complexes were determined, in an attempt to obtain information on the trans influence of the three ligands. The iodo ligand has the greatest trans influence. Chloro and pyridine ligands seem to have similar trans influence, although, the chloro ligand seems to have a slightly larger influence than pyridine derivatives One structure, trans-Pt(2-pic)2I2, showed a syn conformation of the two 2-picoline ligands.

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Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Thermal migration of amines in platinum(II) complexes, published in 1978-08-31, which mentions a compound: 15227-42-6, mainly applied to platinum complex amine thermal migration; ammine thermal migration platinum complex; pyridine thermal migration platinum complex; methylamine thermal migration platinum complex; ethylenediamine thermal migration platinum complex; aniline thermal migration platinum complex; quinoline thermal migration platinum complex; picoline thermal migration platinum complex; toluidine thermal migration platinum complex; piperidine thermal migration platinum complex; hydroxyquinoline thermal migration platinum complex, Related Products of 15227-42-6.

Derivatog. data indicate that the 1st stage of the thermal conversion of (LH)2[PtCl4] (L = NH3, MeNH2, piperidine, pyridine, γ-picoline, PhNH2, p-toluidine, 8-hydroxyquinoline, quinoline) or (enH2)[PtCl4] is the cleavage of HCl and the formation of PtL2Cl2. All the complexes studied fall into 2 groups according to the temperature of the beginning of the process: (1) complexes with a temperature for the start of thermal reaction at 180 – 200° contain amines the basicity constants of which are >10-5 and (2) complexes with decomposition temperatures at 130-50° contain amines the basicity constants of which are <10-8. Although many compounds look similar to this compound(15227-42-6)Related Products of 15227-42-6, numerous studies have shown that this compound(SMILES:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Stetsenko, A. I.; Dmitrieva, E. S.; Yakovlev, K. I. published an article about the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2 ).Application of 15227-42-6. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:15227-42-6) through the article.

[Pt2(NH3)4Cl2L]Cl2 (L = adenine, adenosine) were prepared by the addition of ligand to cis-[Pt(NH3)2Cl2] solution [Pt(NH3)2L](NO3)2 were obtained by adding L to cis-[Pt(NH3)2(H2O)2](NO3)2 solution 2-Aminopyrimidine (L1) and 2-amino-4-phenylpyrimidine (L2) reacted with aqueous K2[PtCl4] to yield trans-[PtL12Cl2] and trans-[PtL22Cl2], resp. The cis-[PtA2L12]Cl2 (A = NH3, pyridine, 0.5 ethylenediamine) were obtained by the substitution reaction of cis-[PtA2Cl2] with 2-aminopyrimidine. The cis-[PtA2(H2O)2](NO3)2 reacted with 2-aminopyrimidine to afford cis-[PtA2L12](NO3)2 and cis-[PtA2L1](NO3)2 (A = NH3, 0.5 ethylenediamine), depending on the stoichiometric ratios of the reactants.

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Tetrahydroisoquinoline – Wikipedia,
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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Spectra and structure of pyridine coordination compounds》. Authors are Herbelin, F.; Herbelin, J. D.; Mathieu, J. P.; Poulet, H..The article about the compound:cis-Dichlorobis(pyridine)platinum(II)cas:15227-42-6,SMILESS:[Cl-][Pt+2]([N]1=CC=CC=C1)([Cl-])[N]2=CC=CC=C2).Quality Control of cis-Dichlorobis(pyridine)platinum(II). Through the article, more information about this compound (cas:15227-42-6) is conveyed.

Ir absorption spectra of 15 coordination compounds of pyridine with Pt, Rh, and Ir have been observed, 100-3200 cm.-1; in some cases uv and Raman spectra have also been observed. The effect of coordination on the vibration spectrum of pyridine, the structure of the coordinated units, and the differences in the spectra of cis-trans isomers are discussed.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Berezin, V. I.; Ganin, V. V.; Kovrikov, A. B.; Lipnitskii, I. V.; Rogalevich, N. L. published the article 《Spectral and structural properties of the crystalline complex dichlorodi(pyridine)palladium》. Keywords: IR Raman palladium pyridine chloride.They researched the compound: cis-Dichlorobis(pyridine)platinum(II)( cas:15227-42-6 ).COA of Formula: C10H10Cl2N2Pt. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:15227-42-6) here.

An IR and Raman spectroscopic investigation of crystalline PdPy2Cl2 was made. The vibrational frequencies were measured in the region from 3500 to 30 cm-1. The assignments of the observed bands were made on the basis of the frequency calculation for trans- and cis-PdPy2Cl2 plane and nonplanar configurations, using force constants, modelled from constants of [Pd(NH3)4]2+ and [PdCl4]2-. The calculation results were used to specify the metal-ligands stretching constants and their interactions.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3-(2,5-Dichloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole( cas:882562-40-5 ) is researched.HPLC of Formula: 882562-40-5.Kwiatkowski, Nicholas; Zhang, Tinghu; Rahl, Peter B.; Abraham, Brian J.; Reddy, Jessica; Ficarro, Scott B.; Dastur, Anahita; Amzallag, Arnaud; Ramaswamy, Sridhar; Tesar, Bethany; Jenkins, Catherine E.; Hannett, Nancy M.; McMillin, Douglas; Sanda, Takaomi; Sim, Taebo; Kim, Nam Doo; Look, Thomas; Mitsiades, Constantine S.; Weng, Andrew P.; Brown, Jennifer R.; Benes, Cyril H.; Marto, Jarrod A.; Young, Richard A.; Gray, Nathanael S. published the article 《Targeting transcription regulation in cancer with a covalent CDK7 inhibitor》 about this compound( cas:882562-40-5 ) in Nature (London, United Kingdom). Keywords: THZ1 THZ1R bioTHZ1 preparation transcription regulation antitumor CDK7 inhibitor; phenylaminopyrimidine derivative THZ1 preparation antitumor CDK7 inhibitor transcription. Let’s learn more about this compound (cas:882562-40-5).

Tumor oncogenes include transcription factors that co-opt the general transcriptional machinery to sustain the oncogenic state, but direct pharmacol. inhibition of transcription factors has so far proven difficult. However, the transcriptional machinery contains various enzymic cofactors that can be targeted for the development of new therapeutic candidates, including cyclin-dependent kinases (CDKs). Here the authors present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. Cancer cell-line profiling indicates that a subset of cancer cell lines, including human T-cell acute lymphoblastic leukemia (T-ALL), have exceptional sensitivity to THZ1. Genome-wide anal. in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry of these tumor cells. Pharmacol. modulation of CDK7 kinase activity may thus provide an approach to identify and treat tumor types that are dependent on transcription for maintenance of the oncogenic state.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: cis-Dichlorobis(pyridine)platinum(II), is researched, Molecular C10H10Cl2N2Pt, CAS is 15227-42-6, about Ligand effects in platinum binding to DNA. A comparison of DNA binding properties for cis- and trans-[PtCl2(amine)2] (amine = NH3, pyridine), the main research direction is DNA binding platinum pyridine complex.Electric Literature of C10H10Cl2N2Pt.

The DNA binding properties of cis- and trans-[PtCl2(pyridine)2] have been examined and compared with their NH3 analogs, cis- and trans-DDP. The presence of a planar ligand reduces the rates of DNA binding but does not greatly affect the overall conformation of CT DNA, as measured by CD spectroscopy. The sequence specificity of trans-[PtCl2(py)2] includes alternating purine-pyrimidine sequences. The sequence specificity is further different between the two pyridine isomers, and the steric effects of two cis-pyridine groups are demonstrated by the appearance of relatively few binding sites in the 49-bp duplex. The effects of the pyridine ligand are further manifested by a greatly enhanced DNA-DNA interstrand crosslinking efficiency for the trans isomer, with a cross-link per adduct frequency of between 0.14 and 0.23, depending on the rb of the sample. The unwinding of closed circular pUC19 DNA by trans-[PtCl2(pyridine)2] is also more efficient than that by either DDP isomer. In contrast, little unwinding is induced by cis-[PtCl2(pyridine)2]. These results invert the standard cis/trans structure-activity relationships observed previously for [PtCl2(NH3)2]. The results are discussed with respect to the previously demonstrated effect of activation of the trans-platinum geometry using sterically hindered ligands.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 15227-42-6, is researched, Molecular C10H10Cl2N2Pt, about Electrochemical reduction of geometric isomers of [Pt(C5H5N)2Cl2Br2] on a dropping mercury electrode in propylene carbonate solutions, the main research direction is electrochem reduction geometric isomer platinum complex; redox reaction coordinated pyridine platinum complex; pyridine halo platinum complex electroreduction; bromo chloro pyridine platinum complex electroreduction.Quality Control of cis-Dichlorobis(pyridine)platinum(II).

The method of classical polarog. on a dropping Hg electrode in propylene carbonate was used to study the reduction of the isomeric complexes of Pt(IV) of type [Pt(C5H5N)2Cl2Br2] and of Pt(II) of type [Pt(C5H5N)2X2], where X = Cl, Br. The reduction of cis,cis,trans-[Pt(C5H5N)2Cl2Br2] and of cis,trans,cis-[Pt(C5H5N)2Cl2Br2] occurs according to an electrochem.-chem. mechanism during which, and following the 1-electron reduction of Pt(IV) to Pt(III), there occurs an intramol. redox process with participation of coordinated pyridine.

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Reference:
Tetrahydroisoquinoline – Wikipedia,
1,2,3,4-Tetrahydroisoquinoline | C9H11N – PubChem